Point mutations of the P53 gene, human hepatocellular carcinoma and aflatoxins [PDF]
, 1993 The tumor suppressor p53 exerts important protective functions towards DNA-damaging agents. Its inactivation by allelic deletions or point mutations within the P53 gene as well as complex formation of wildtype p53 with cellular or viral proteins is a ...
Alexander L. Gerbes +40 more
core +1 more source
Potential mutations associated with occult hepatitis B virus status [PDF]
, 2014 Context: Occult hepatitis B virus (HBV) status (OHBS) is simply defined as the presence of HBV DNA in the liver (with or without detectable HBV DNA in the serum), in the absence of serum HBV surface antigen (HBsAg). Importance of OHBS is mostly clinical,
Besharat, S. +2 more
core +1 more source
Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels [PDF]
, 2008 Background/aim: To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. Methods: HBV genotypes, 1653/1753/core promoter (CP)/precore MT
But, DYK +10 more
core +1 more source
Occult HBV infection among Egyptian hepatocellular carcinoma patients
Virology Journal, 2011 Background Occult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed the occult HBV-genotypes in HCC patients. Methods To achieve our objective, matched serum
Mansor Tarek M +3 more
doaj +1 more source
Requirement of Activation for Hepatitis B Virus Infection [PDF]
, 2007 Although _in vitro_ models of human hepatitis B virus replication are established, so far none could approximate infection efficiency as expected from _in vivo_ observations.
Claudia Maenz, Michael Bruns
core +1 more source
Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? A population-level analysis [PDF]
, 2018 Chronic coinfection with hepatitis C virus (HCV) and hepatitis B virus (HBV) is associated with adverse liver outcomes. The clinical impact of previous HBV infection on liver disease in HCV infection is unknown. We aimed at determining any association of
Allen, S. +20 more
core +4 more sources
HBV DNA preC/C amplification v2
, 2018 PreC-C Primers encompass described PreC-C mutations: mutation G1896A in the PreC region and mutations A1762T and G1764A in C-gene promotor. Primers were modified according to literature-based alignment, in order to optimize the amplification of all HBV genotypes.
Paul Dény +3 more
openaire +1 more source
Central obesity and advanced liver stiffness in Hepatitis B: Result from golestan hepatitis B cohort study [PDF]
, 2015 Background: Chronic infection with the hepatitis B virus and obesity may both contribute synergistically to liver disease, although relatively few studies have investigated this hypothesis.
Besharat, S. +6 more
core
Application of hepatitis B virus (HBV) DNA sequence polymorphisms to the study of HBV transmission [PDF]
, 1991 Short sequences in hypervariable regions of the hepatitis B virus (HBV) genome can be used to identify different strains, providing a novel approach to the study of HBV transmission.
Fong, MW +5 more
core +1 more source
HBV DNA PreS1-PreS2 amplification v2
, 2018 This protocol aims to amplify the PreS1/PreS2 region of the Hepatitis B genome. It can be obtained from a single PCR giving an amplified product of 479 bp. However genotype D stains have typically a deletion in this region of 33 nucleotides, giving an amplified product of 446 bp.
Paul Dény +3 more
openaire +1 more source