Mechanisms and Management Strategies of Hepatocarcinogenesis Driven by Chronic Hepatitis B Comorbid with Type 2 Diabetes. [PDF]
Lou Q, Cai J, Yin J.
europepmc +1 more source
Hepatitis B virus promotes hepatocellular carcinoma progression by disrupting NSUN2/YBX1-mediated m<sup>5</sup>C modification of PTEN mRNA. [PDF]
Lin M, Chen K, Li H, Lin X, Wu S, Lin X.
europepmc +1 more source
Discovery and structural characterization of newly identified mutations in the HBx gene of chronic HBV patients. [PDF]
Jalali KM, Roudbaneh EM.
europepmc +1 more source
Expression of HBx protein in hepatitis B virus-infected intrahepatic cholangiocarcinoma
BACKGROUND: Hepatitis B virus (HBV) is an etiological factor of intrahepatic cholangiocarcinoma (ICC), but the pathogenic mechanisms remain unclear.
Yan-Ming Zhou, Zheng-Feng Yin
exaly +5 more sources
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HBx Protein Potentiates Hepatitis B Virus Reactivation
Molecular Biology, 2022Hepatitis B virus (HBV) can cause chronic hepatitis B, one of the most prevalent infectious diseases in the world. Global estimates suggest that over 2 billion people are affected by HBV, with over 250 million people developing chronic infection. Upon treatment of comorbidities, patients with chronic infection may develop an abrupt increase of viral ...
S A, Brezgin +9 more
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Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus
The hepatitis B virus x protein (HBX) is expressed in HBV-infected liver cells and can interact with a wide range of cellular proteins. In order to understand such promiscuous behavior of HBX we expressed a truncated mini-HBX protein (named Tr-HBX ...
Kyou-Hoon Han +2 more
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Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication [PDF]
Robust hepatitis B virus (HBV) replication is stimulated by the regulatory HBx protein. HBx binds the cellular protein DDB1; however, the importance of this interaction for HBV replication remains unknown.
Betty Slagle +2 more
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Understanding the function of the hepatitis B virus X protein (HBx) is fundamental to elucidating the underlying mechanisms of hepatitis and hepatocarcinogenesis caused by hepatitis B virus (HBV) infection. We identified heat shock protein 60 (Hsp60) as a novel cellular target of HBx by the combination of affinity purification and mass spectrometry ...
Yasuo, Tanaka +11 more
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Hepatitis B virus X (HBx) protein implicated in the development of liver cancer may inhibit the function of p53 tumor suppressor protein through cytoplasmic retention of p53 protein.
Chawon Yun, Hyeseong Cho, Jae-Ho Lee
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