Results 171 to 180 of about 3,362,872 (199)

Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx

Cancer Letters, 2009
The progression of hepatocellular carcinoma (HCC) is known to be strongly related to overexpression of hepatitis Bx (HBx) protein and dysfunction of p53. While the inhibition of p53 by HBx is well known, the effect of p53 on HBx function has not been well studied. In this report, we found that p53 affects the stability of HBx protein. Overexpression of
Sung Gyoo, Park, Ji Young, Min, Chan, Chung, Antony, Hsieh, Guhung, Jung   +4 more
openaire   +2 more sources

Characterization of the mitochondrial association of hepatitis B virus X protein, HBx

Mitochondrion, 2002
Chronic infection with hepatitis B virus (HBV) is strongly associated with the development of hepatocellular carcinoma (HCC). HBx, a protein encoded by HBV is believed to contribute to the development of HCC. HBx was recently shown to associate with mitochondria. In this study, we mapped region(s) of HBx necessary for mitochondrial targeting and showed
Aleem Siddiqui
exaly   +3 more sources

In vitro tumorigenicity of hepatitis B virus DNA and HBx protein

Journal of Hepatology, 1991
Persistent infection by hepatitis B virus (HBV) is strongly associated with the development of hepatocellular carcinoma. This linkage may be caused by oncogenic HBV gene products. Our initial in vitro studies have revealed that a non-tumorigenic, fetal mouse hepatocyte line (FMH202-1), harboring simian virus 40 large tumor antigen (SV40TAg) as ...
M, Seifer, M, Höhne, S, Schaefer, W H, Gerlich   +3 more
openaire   +2 more sources

Calcium Signaling by HBx Protein in Hepatitis B Virus DNA Replication

Science, 2001
Hepatitis B virus (HBV) infects more than 300 million people and is a leading cause of liver cancer and disease. The HBV HBx protein is essential for infection; HBx activation of Src is important for HBV DNA replication. In our study, HBx activated cytosolic calcium-dependent proline-rich tyrosine kinase–2 (Pyk2), a Src kinase activator. HBx activation
M J, Bouchard, L H, Wang, R J, Schneider
openaire   +2 more sources

Akt augments the oncogenic potential of the HBx protein of hepatitis B virus by phosphorylation

FEBS Journal, 2012
Hepatitis B virus X protein (HBx) is a putative viral oncoprotein that plays an important role in various cellular processes, including modulation of the phosphatidylinositol 3‐kinase/Akt signalling pathway. However, the molecular mechanism of Akt activation remains elusive.
Ekta Khattar, Atish Mukherji
exaly   +3 more sources

Assignment of Disulfide Bonds in the X Protein (HBx) of Hepatitis B Virus

Biochemical and Biophysical Research Communications, 1995
We have established the disulphide arrangement of cysteines in E. coli expressed HBx by chromatographic analysis of enzymatically cleaved protein and sequence analysis of cysteine containing fragments. Eight of the nine cysteines are disulphide linked in an interesting pattern.
A, Gupta, T K, Mal, N, Jayasuryan, V S, Chauhan   +3 more
openaire   +2 more sources

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2

Molecular Biology Reports, 2009
Hepatitis B virus X protein (HBx) is closely involved in the development of hepatocellular carcinoma (HCC). Tumor suppressor p53 was reported to induce HBx degradation and repress its oncogenic function recently, but the molecular mechanism is unknown. In this study, we attempted to identify the underlying mechanism. We found that overexpression of p53
Zhou Fang, Wenzhang Wang
exaly   +3 more sources

[Establishment of hepatic stem cell line stably expressing HBx protein and the effect of HBx on cell proliferation].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 2013
To establish HP14.5 cell line stably expressing hepatitis B virus X (HBx) and detect the effect of HBx on cell proliferation, cell cycle and the wnt/β-catenin signal pathway of hepatic progenitor cells.The plasmid of pSEB-Flag-HBx and the packaging plasmid pAmpho were co-transfected into HEK 293T cells to construct the recombinant retrovirus carrying ...
Yongliang, Lu, Lihong, Shen, Hongli, Li, Daixi, Hu, Xifeng, Zhang, Bin, Hu, Tao, Feng, Jiayi, Huang   +7 more
openaire   +1 more source

Sorafenib overcomes the chemoresistance in HBx-expressing hepatocellular carcinoma cells through down-regulation of HBx protein stability and suppresses HBV gene expression

Cancer Letters, 2014
Previous studies have revealed that HBx expression has anti-apoptotic effects, resulting in increased drug resistance in HCC cells. Thus, we examined if sorafenib efficiently induces apoptosis in HBx-overexpressing HCC cells. Noticeably, sorafenib efficiently induced apoptosis, even in HBx-expressing HepG2 cells, indicating that the HBx protein does ...
Hye Young, Kim, Hye Uk, Jung, Seung Hee, Yoo, Ki Soo, Yoo, JaeHun, Cheong, Bong Soo, Park, Il, Yun, Young Hyun, Yoo   +7 more
openaire   +2 more sources

[The HBx protein expression in liver cancer].

Zhonghua bing li xue za zhi = Chinese journal of pathology, 1991
The expression of HBx protein in liver tissues from 48 cases of different liver diseases, including 32 cases of hepatocellular carcinoma (HCC), 10 of chronic hepatitis (CH), 2 of angioma and 4 cases of normal liver was studied. These samples were tested for HBx protein, HBsAg by modified ABC method.
openaire   +1 more source