Results 91 to 100 of about 310,541 (331)

Deciphering Tumor Heterogeneity in Hepatocellular Carcinoma (HCC)—Multi-Omic and Singulomic Approaches [PDF]

, 2021
Renumathy Dhanasekaran
openalex   +1 more source

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Functional evaluation of hepatic parenchyma with dynamic tests (Indocyanine green and Hippurate ratio) in patients with HCC [PDF]

, 2011
Our aim was to assess hepatic functionality in patients with HCC and candidate for liver resection. We used dynamic tests of liver functionality Indocyanine green (ICG) and Hippurate ratio, for the evaluation of surgical risk and postoperative clinical
PETRACCIA, LUISA
core  

Hypoxia up-regulates SERPINB3 through HIF-2\u3b1 in human liver cancer cells. [PDF]

, 2015
SERPINB3 is a cysteine-proteases inhibitor up-regulated in a significant number of cirrhotic patients carrying hepatocellular carcinoma (HCC) and recently proposed as a prognostic marker for HCC early recurrence.
Autelli, Riccardo, Biasiolo, A, Cambieri, I, Cannito, Stefania, Cillo, U, Cillo, U, Colombatto, Sebastiano, David, E, Fasolato, S, Morello, E, Musso, Tiziana, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Pontisso, P, Quarta, S, Rovida, E, Smedile, Antonina, Turato, C, Tusa, I, Villano, G   +20 more
core   +3 more sources

Elemene Augments the Effects of Anti‐PD‐1 Immunotherapy on Hepatocellular Carcinoma by Regulating the miR‐130a‐5p/SPP/MHC‐I Axis

Advanced Science, EarlyView.
Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang, Mengqing Sun, Heng Dong, Xiaoting Zhang, Jingbo Zhang, Zhengguo Zhang, Mengjie Ni, Lina Li, Yunxin Pei, Xiaoyu Chen, Qian Li, Fangtian Bu, Jiacheng Huang, Liangyu Jiang, Zhuting Fang, Xuliang Chen, Jianxiang Chen, Yiting Qiao, Tian Xie   +18 more
wiley   +1 more source

Reversion of tumor hepatocytes to normal hepatocytes during liver tumor regression in an oncogene-expressing transgenic zebrafish model

Disease Models & Mechanisms, 2019
Tumors are frequently dependent on primary oncogenes to maintain their malignant properties (known as ‘oncogene addiction’). We have previously established several inducible hepatocellular carcinoma (HCC) models in zebrafish by transgenic expression of ...
Yan Li, Ira Agrawal, Zhiyuan Gong
doaj   +1 more source

Respiration-Induced Intraorgan Deformation of the Liver: Implications for Treatment Planning in Patients Treated With Fiducial Tracking. [PDF]

, 2017
Stereotactic body radiation therapy is a well-tolerated modality for the treatment of primary and metastatic liver lesions, and fiducials are often used as surrogates for tumor tracking during treatment. We evaluated respiratory-induced liver deformation
Anwar, Mekhail, Chang, Albert J, Descovich, Martina, Gottschalk, Alexander R, Paulsson, Anna K, Pinnaduwage, Dilini, Sudhyadhom, Atchar, Yom, Sue S   +7 more
core   +1 more source

LRP1B suppresses HCC progression through the NCSTN/PI3K/AKT signaling axis and affects doxorubicin resistance

, 2022
Xiangyu Zhai, Zhijia Xia, Gang Du, Xinlu Zhang, Tong Xia, Delin Ma, Xiaosong Li, Bin Jin, Hao Zhang   +8 more
openalex   +1 more source

Giant Small‐Molecule Donors With Controlled Backbone Planarity Afford High‐Performance and Photostable Organic Solar Cells

Advanced Science, EarlyView.
Efficient and photostable organic solar cells (OSCs) are developed using giant small‐molecule donors (GSMDs) with controlled backbone planarity. By tuning alkyl side chain orientation, anti‐configured GSMD improved crystallinity and charge transport, yielding PCE of 15.4% and superior stability (t80% > 1500 h).
Hyerin Jeon, Seunghoon Song, Jin‐Woo Lee, Yun‐Hi Kim, Bumjoon J. Kim   +4 more
wiley   +1 more source

DNAM1 and 2B4 Costimulatory Domains Enhance the Cytotoxicity of Anti-GPC3 Chimeric Antigen Receptor-Modified Natural Killer Cells Against Hepatocellular Cancer Cells in vitro

Cancer Management and Research, 2020
Yao Huang,1,2 Jianxing Zeng,2 Teng Liu,2 Qingyi Xu,2 Xianglin Song,2 Jinhua Zeng1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Hepatic
Huang Y, Zeng J, Liu T, Xu Q, Song X, Zeng J   +5 more
doaj