Results 111 to 120 of about 277,119 (298)

Evolving epidemiology of HCC in Spain

JHEP Reports
The epidemiological landscape of hepatocellular carcinoma (HCC) in Europe is evolving. This study aims to provide an updated description of the current epidemiology of liver cancer in Spain.This multicenter prospective study collected demographic and clinical data on primary liver cancer between October 2022 and January 2023.
Margarita Sala, Sonia Pascual, Maria Rosa Rota Roca, Ana María Matilla, Marta Campos, Manuel Delgado, María Teresa Ferrer, José Luís Montero, Jesús Manuel González-Santiago, Antonio Guerrero, Carles Aracil, Carlos Rodríguez-Lope, Marta Romero-Gutiérrez, Miguel Sogbe, Sergio Vázquez-Rodríguez, Javier Fuentes Olmo, Beatriz Mínguez, Luís Cortés-García, Nicolau Vallejo-Senra, Paloma Rendón Unceta, Ariadna Clos, Dácil Díaz-Bethencourt, Araceli García Sánchez, Raisa Quiñones Castro, Javier Bustamante, Christie Perelló, Juan José Urquijo Ponce, Hernán Andreu Serra, Camilo Julio Llamoza-Torres, Silvia Montoliu, Cristina Fernández-Marcos, Ana Guiberteau, Manuel Hernández-Guerra, Mercedes Vergara, Alexia María Fernández-López, María Paz Valer López-Fando, María Luisa Gutiérrez-García, Tánia Hernáez-Alsina, Susana Coll, Berta Cuyás, María Julia Morillas, Susana Rebolledo Olmedo, Miguel Fernández-Bermejo, Mercè Roget, Irina Calvo Ramos, Gemma Pacheco del Río, Raimon Rifà, Pilar Conde Gacho, Mónica Llorente Barrio, Mariano Gómez-Rubio, Irene Peñas, Isabel Serra, Alba Cachero, María Reig, Álvaro Giraldez, Marta Guerrero, José Xavier Segarra, José Luis Lledó, Álvaro Díaz-González, Carolina Delgado, Mercedes Iñarrairaegui, María Milagros Rodríguez-González, María Lázaro, María Bermúdez-Ramos, Alberto Lué, Esther Molina, Manuel Alberto Macías-Rodríguez, Manuel Rodríguez, Valentina Chiminazzo, María Varela   +69 more
openaire   +5 more sources

Microphysiological Solid Tumor Models in Hydrogel Beads for CAR T Cell Immunotherapy Evaluation

Advanced Science, EarlyView.
The complex physical and biochemical barriers of the tumor microenvironment are major triggers of immune exclusion. Here, a 3D micrometastasis model is developed to mimic key microenvironmental cues, enabling in vitro evaluation of chimeric antigen receptor (CAR) T cell immunotherapy. Abstract Micrometastases are challenging to resect surgically and to
Xuan Peng, Željko Janićijević, Liliana R. Loureiro, Lydia Hoffmann, Poh Soo Lee, Isli Cela, Benjamin Kruppke, Alexandra Kegler, Anja Feldmann, Ielizaveta Gorodetska, Anja Madleine Markl, Anna Dubrovska, Anne Kathrin Offermann, Michael Bachmann, Larysa Baraban   +14 more
wiley   +1 more source

Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

Nature reviews: Gastroenterology & hepatology, 2020
Daniel Q. Huang, H. El‐Serag, R. Loomba   +2 more
semanticscholar   +1 more source

Clathrin Light Chain B Drives Hepatocellular Carcinoma Progression Through Dual Mechanisms: Small Extracellular Vesicle‐Mediated Angiogenesis and the NF‐κB–PCLAF Signaling Axis

Advanced Science, EarlyView.
Clathrin Light Chain B (CLTB) drives hepatocellular carcinoma progression through dual pathways: intracellularly, it activates the NF‐κB–PCLAF axis to enhance small extracellular vesicle (sEV) uptake and tumor proliferation; extracellularly, CLTB‐enriched sEVs bind SH3KBP1 to inhibit its degradation, inducing angiogenesis and vascular leakage ...
Xiaoke Sun, Junchen Guo, Ning Zhao, Guanghua Cui, Yun Bai, Meijuan Ding, Yi Xu, Yu Yang   +7 more
wiley   +1 more source

Regulation of Macrophage Activation and Polarization by HCC-Derived Exosomal lncRNA TUC339

International Journal of Molecular Sciences, 2018
Exosomes released by cells can serve as vehicles for delivery of biological materials and signals. Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nt, which roles are increasingly appreciated in various biological content.
Xue Li, Y. Lei, Miao Wu, Nan Li
semanticscholar   +1 more source

Avidity‐Based Capture of PD‐L1‐Expressing Exosomes via Dendrimer–Peptide Conjugates: A Nanoengineered Platform for Enhanced Prediction of Immunotherapy Response

Advanced Science, EarlyView.
This study introduces a dendrimer‐peptide conjugate platform (G7‐pPDL1) for avidity‐based capture of PD‐L1‐expressing exosomes. The system exhibits enhanced binding kinetics and exosome capture efficiency, enabling accurate prediction of immunotherapy outcomes.
Jiah Lee, Dongjun Shin, Chae Yeon Son, Hanbit Kang, Jung Hyun Choi, Hyun Sung Park, Seha Bang, Lucia Kim, Tae Hee Lee, Hyuk Soo Eun, Michael J Poellmann, Woo‐jin Jeong, Dong Hyung Kim, Jun Hyeok Lim, Seungpyo Hong, Jiyoon Bu   +15 more
wiley   +1 more source

Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification.

Advances in Cancer Research, 2021
Saranya Chidambaranathan-Reghupaty, P. Fisher, D. Sarkar   +2 more
semanticscholar   +1 more source

Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

Journal of Hematology & Oncology, 2019
BackgroundIncreased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes.
Yinying Dong, Qiongdan Zheng, Zhiming Wang, Xiahui Lin, Yang You, Sifan Wu, Yaohui Wang, Chao Hu, Xiaoying Xie, Jie Chen, Dongmei Gao, Yan Zhao, Weizhong Wu, Yin‐kun Liu, Z. Ren, Rongxin Chen, Jiefeng Cui   +16 more
semanticscholar   +1 more source

Hyaluronic Acid Hydrogel Implants for Sustained Release of Oxaliplatin and Resiquimod to Prevent Hepatocellular Carcinoma Recurrence Post‐Radiofrequency Ablation

Advanced Science, EarlyView.
Preparation of a biopolymer‐based immune implant (BI) for the sustained release of R848 and oxaliplatin (OXA), enabling immune activation and preventing recurrence after radiofrequency ablation (RFA) treatment in hepatocellular carcinoma (HCC). Abstract Hepatocellular carcinoma (HCC) remains a global challenge due to limited therapies and high ...
Yuezhan Shan, Hongyu Chu, Sheyu Ye, Guofeng Ji, Jiayi Zhao, Xinghui Si, Yumin Zhong, Youmao Tao, Jingwei Shi, Xuedong Fang   +9 more
wiley   +1 more source

Circulating miR-210 and miR-1246 as potential biomarkers for differentiating hepatocellular carcinoma from metastatic tumors in the liver [PDF]

Journal of Medical Biochemistry, 2019
Background: To date few reports have pointed out the role of circulating miRNAs in discriminating metastatic liver tumors from primary hepatocellular (HCC) tumors. Such discrimination will have significant therapeutic and prognostic implications.
Ahmed Emad K., Fahmy Shaimaa A., Effat Heba, Abdel-Wahab Abdel Hady   +3 more
doaj