Advanced Science, EarlyView.A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu +9 more
wiley +1 more source
The Evolution, Expansion and Evaluation of the Family Economic Security Program [PDF]
, 2016 In 2008, the Fund for Women & Girls of Fairfield County's Community Foundation created the Family Economic Security Program (FESP). The goal of the program is to assist low- and moderate-income working students – particularly women who are single parents
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A model based on adipose and muscle-related indicators evaluated by CT images for predicting microvascular invasion in HCC patients [PDF]
, 2023 Xin‐Cheng Mao +14 more
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Advanced Science, EarlyView.HiST, a multiscale deep learning framework, reconstructs spatially resolved gene expression profiles directly from histological images. It accurately identifies tumor regions, captures intratumoral heterogeneity, and predicts patient prognosis and immunotherapy response.
Wei Li +8 more
wiley +1 more source
Circulating miR-210 and miR-1246 as potential biomarkers for differentiating hepatocellular carcinoma from metastatic tumors in the liver [PDF]
Journal of Medical Biochemistry, 2019 Background: To date few reports have pointed out the role of circulating miRNAs in discriminating metastatic liver tumors from primary hepatocellular (HCC) tumors. Such discrimination will have significant therapeutic and prognostic implications.
Ahmed Emad K. +3 more
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PUS1 May Be a Potential Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma
Pharmacogenomics and Personalized Medicine, 2023 Chenlu Lan,1,2,* Xinlei Huang,1,2,* Xiwen Liao,1,2 Xin Zhou,1,2 Kai Peng,1,2 Yongguang Wei,1,2 Chuangye Han,1,2 Tao Peng,1,2 Jianyao Wang,3 Guangzhi Zhu1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical ...
Lan C +9 more
doaj
113. Increased Occurrence of Hepatocellular Carcinoma (HCC) in Mice after Neonatal Adeno-Associated Virus (AAV8) Gene Delivery Exhibits Dose-Dependent Tumorigenesis [PDF]
, 2013 openalex +1 more source
A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β
Advanced Science, EarlyView.This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo +12 more
wiley +1 more source
Advanced Science, EarlyView.Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao +8 more
wiley +1 more source
Cancer‐Like Fragmentomic Characteristics of Somatic Variants in Cell‐Free DNA
Advanced Science, EarlyView.We report that in non‐cancerous subjects, cell‐free (cfDNA) molecules harboring somatic variants exhibit cancer‐like fragmentomic characteristics associated with clonal hematopoiesis. Importantly, these somatic variant‐associated fragmentomic aberrations are more pronounced in cancer patients. Leveraging such somatic variant‐associated signals in cfDNA,
Zhenyu Zhang +12 more
wiley +1 more source