Results 11 to 20 of about 400,342 (335)
Gut microbiota–derived short‐chain fatty acids regulate group 3 innate lymphoid cells in HCC
Hepatology, EarlyView., 2022 Abstract Background and Aims Type 3 innate lymphoid cells (ILC3s) are essential for host defense against infection and tissue homeostasis. However, their role in the development of HCC has not been adequately confirmed. In this study, we investigated the immunomodulatory role of short‐chain fatty acids (SCFAs) derived from intestinal microbiota in ILC3
Chupeng Hu +11 more
wiley +2 more sources
NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Nature, 2021 Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal ...
D. Pfister +109 more
semanticscholar +1 more source
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR
Molecular Cancer, 2023 Background hsa_circ_0001727 (circZKSCAN1) has been reported to be a tumor-associated circRNA by sponging microRNAs. Intriguingly, we found that circZKSCAN1 encoded a secretory peptide (circZKSaa) in the liver.
Runjie Song +16 more
semanticscholar +1 more source
Global epidemiology of alcohol-associated cirrhosis and HCC: trends, projections and risk factors
Nature reviews: Gastroenterology & hepatology, 2022 Global alcohol consumption per capita rose from 5.5 litres in 2005 to 6.4 litres in 2016 and is projected to increase further to 7.6 litres in 2030. Currently, Europe has the highest levels of alcohol consumption; however, it is projected to be surpassed
Daniel Q. Huang +3 more
semanticscholar +1 more source
Emerging Therapies for Hepatocellular Carcinoma (HCC)
Cancers, 2022 Simple Summary Primary liver cancer, also known as Hepatocellular carcinoma (HCC), is considered to be a major global health challenge. Due to delays in diagnosis at early asymptomatic stages, HCC reaches a severe aggressive stage, thereby having a ...
Eesha Chakraborty, D. Sarkar
semanticscholar +1 more source
Immune System and Hepatocellular Carcinoma (HCC): New Insights into HCC Progression
International Journal of Molecular Sciences, 2023 According to the WHO’s recently released worldwide cancer data for 2020, liver cancer ranks sixth in morbidity and third in mortality among all malignancies. Hepatocellular carcinoma (HCC), the most common kind of liver cancer, accounts approximately for
Maria Kotsari +3 more
semanticscholar +1 more source
Yttrium‐90 Radioembolization for the Treatment of Solitary, Unresectable HCC: The LEGACY Study
Hepatology, 2021 Locoregional therapies, including yttrium‐90 radioembolization, play an important role in the treatment of unresectable HCC. The aim of the LEGACY (Local radioEmbolization using Glass Microspheres for the Assessment of Tumor Control with Y‐90) study was ...
R. Salem +8 more
semanticscholar +1 more source
Mechanism of sorafenib resistance associated with ferroptosis in HCC
Frontiers in Pharmacology, 2023 Hepatocellular carcinoma (HCC) is the most familiar primary hepatic malignancy with a poor prognosis. The incidence of HCC and the associated deaths have risen in recent decades.
Lingling Guo +3 more
semanticscholar +1 more source
Inflamed and non-inflamed classes of HCC: a revised immunogenomic classification
Gut, 2022 Objective We previously reported a characterisation of the hepatocellular carcinoma (HCC) immune contexture and described an immune-specific class. We now aim to further delineate the immunogenomic classification of HCC to incorporate features that ...
C. Montironi +28 more
semanticscholar +1 more source
CXCR2 inhibition enables NASH-HCC immunotherapy
Gut, 2022 Objective Hepatocellular carcinoma (HCC) is increasingly associated with non-alcoholic steatohepatitis (NASH). HCC immunotherapy offers great promise; however, recent data suggests NASH-HCC may be less sensitive to conventional immune checkpoint ...
J. Leslie +45 more
semanticscholar +1 more source