Results 121 to 130 of about 21,262 (243)

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes [PDF]

, 2015
Salt-inducible kinase 2 (SIK2) is an AMP-activated protein kinase (AMPK) related kinase abundantly expressed in adipose tissue. Our aim was to identify molecular targets and functions of SIK2 in adipocytes, and to address the role of PKA-mediated ...
Altarejos, Bassel-Duby, Berdeaux, Berggreen, Berggreen, Bittinger, Clark, Dawson, Dentin, Du, Ferguson, Gormand, Hardie, Henriksson, Holzenberger, Horike, Horike, Jansson, Katoh, Koo, Küser-Abali, Lee, Lizcano, Mihaylova, Omar, Patel, Qi, Sasaki, Screaton, Song, Takemori, Than, Uebi, van der Linden, Vandesompele, Walkinshaw, Wang, Wang, Weems, Weems, Wu   +40 more
core   +2 more sources

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

Advanced Science, Volume 13, Issue 3, 14 January 2026.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang, Yiran Fang, Xiatong Huang, Guichuang Ma, Qianqian Mao, Xiansheng Lu, Guangda Rong, Yunfang Yu, Yuanyuan Wang, Zhenhua Huang, Huiying Sun, Jiani Wu, Wenchao Gu, Na Huang, Jianhua Wu, Rui Zhou, Xiaoxiang Rong, Siting Zheng, Shaowei Li, Gaofeng Wang, Ling Wang, Wenjun Qiu, Luyang Jiang, Peng Luo, Yonggang Liu, Jianping Bin, Yulin Liao, Min Shi, Zuqiang Wu, Jiguang Wang, Wangjun Liao, Gang Chen, Dongqiang Zeng   +32 more
wiley   +1 more source

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Novel role and regulation of HDAC4 in cocaine‐related behaviors [PDF]

Addiction Biology, 2017
AbstractEpigenetic mechanisms have been proposed to contribute to persistent aspects of addiction‐related behaviors. One family of epigenetic molecules that may regulate maladaptive behavioral changes produced by cocaine use are the histone deacetylases (HDACs)—key regulators of chromatin and gene expression.
Rachel D. Penrod, Maria B. Carreira, Makoto Taniguchi, Jaswinder Kumar, Stephanie A. Maddox, Christopher W. Cowan   +5 more
openaire   +2 more sources

Dynamics of epigenetic regulation at the single-cell level [PDF]

, 2016
Chromatin regulators play a major role in establishing and maintaining gene expression states. Yet how they control gene expression in single cells, quantitatively and over time, remains unclear.
Antebi, Yaron E., Bintu, Lacramioara, Elowitz, Michael B., Kazuki, Yasuhiro, McCue, Kayla, Oshimura, Mitsuo, Uno, Narumi, Yong, John   +7 more
core   +1 more source

Circular RNAs in Diabetic Foot Ulcers: A Scoping Review of Clinical, Preclinical, and In Silico Evidence on Diagnostic and Therapeutic Potentials

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 1, January 2026.
This figure summarises circRNAs identified as therapeutic or pathogenic targets in animal models of diabetic foot ulcers. Protective circRNAs delivered via exosomes, hypoxia‐preconditioned exosomes, or lipid nanoparticles promote angiogenesis, autophagy, and oxidative stress resistance. In contrast, silencing of pathogenic circRNAs such as circ_0005654
Amir Reza Ghafourian, Masoomeh Hamdi, Atefeh Soltan Mohseni, Maryam Davoudi, Hamid Choobineh, Fariba Nabatchian, Reza Afrisham   +6 more
wiley   +1 more source

Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

BMC Biology
Background Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders.
Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson, Helen L. Fitzsimons   +3 more
doaj   +1 more source

Associations between whole peripheral blood fatty acids and DNA methylation in humans [PDF]

, 2016
Fatty acids (FA) modify DNA methylation in vitro, but limited information is available on whether corresponding associations exist in vivo and reflect any short-term effect of the diet.
Alvarado-Caudillo, Yolanda, Carmona, F. Javier, Cervantes-Paz, Braulio, Esteller, Manel, Hernández-Rivas, Rosaura, Lund, Gertrud, Molina-Torres, Jorge, Pérez-Mojica, J. Eduardo, Ramírez-Chávez, Enrique, Rocha, Carmen de la, Rodríguez-Ríos, Dalia, Tristán-Flores, Fabiola E., Wrobel, Katarzyna, Wrobel, Kazimierz, Zaina, Silvio, Zenteno-De León, Silvia   +15 more
core   +1 more source

Ramalin Ameliorates Alzheimer's Disease Pathology by Targeting BACE1, HDAC6, and MAPK Pathways

MedComm, Volume 7, Issue 1, January 2026.
Ramalin alleviates Alzheimer's disease pathology by selectively inhibiting HDAC6, reducing BACE1 levels, and suppressing neuroinflammation through downregulation of the NLRP3 inflammasome and iNOS. It restores synaptic function impaired by Aβ toxicity and improves cognitive performance in AD mouse models, APP/PS1 and 3xTg‐AD.
Yongeun Cho, Jeongmi Lee, Bo Youn Choi, Jin‐Ho Yun, Sukmin Han, Seung Hyun Baek, Jinsu Park, Yoonsuk Cho, Hark Kyun Kim, Eunae Kim, Leon F. Palomera, Jeein Lim, Yeji Jeon, Jeonghyeong Im, Ju‐Mi Hong, Tai Kyoung Kim, Sung Hyun Kim, Joung Han Yim, Dong‐Gyu Jo   +18 more
wiley   +1 more source

Investigation of selected genomic deletions and duplications in a cohort of 338 patients presenting with syndromic obesity by multiplex ligation-dependent probe amplification using synthetic probes [PDF]

, 2014
Background: Certain rare syndromes with developmental delay or intellectual disability caused by genomic copy number variants (CNVs), either deletions or duplications, are associated with higher rates of obesity.
Bertola, Debora R., Castro, Claudia I. E. de, D'Angelo, Carla S., Kim, Chong A., Koiffmann, Celia P., Lourenco, Charles M., Perez, Ana Beatriz Alvarez, Varela, Monica C.   +7 more
core   +1 more source