Results 131 to 140 of about 21,262 (243)
PKA cuts down on HDAC4 signaling
Journal of Cell Biology, 2011 ![Figure][1] In the presence of PKA and CaMKII, full-length HDAC4 (yellow) is cytoplasmic, but an N-terminal fragment (red) remains in the nucleus. Backs et al. report that protein kinase A (PKA) may protect the heart from stress by inducing the proteolytic cleavage of a ...
openaire +2 more sources
PTHrP targets HDAC4 and HDAC5 to repress chondrocyte hypertrophy
JCI Insight, 2019 During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte hypertrophy. Using multiple mouse genetics models, we demonstrate in vivo that HDAC4 is required for the
Shigeki Nishimori +7 more
openaire +2 more sources
Curcumin ameliorates gestational diabetes in mice partly through activating AMPK
Pharmaceutical Biology, 2019 Context: In vitro and in vivo research has shown that curcumin can alleviate diabetes and the relevant complications. Objective: To investigate the effect of curcumin on gestational diabetes (GD).
Xuehong Lu +4 more
doaj +1 more source
Application of Small Epigenetic Modulators in Pediatric Medulloblastoma [PDF]
, 2018 Medulloblastoma is one of the most frequent among pediatric brain tumors, and it has been classified in various subgroups. Some of them already benefit from quite good therapeutic options, whereas others urgently need novel therapeutic approaches ...
Annalisa Romanelli +8 more
core +2 more sources
Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.ABSTRACT This study assessed the anticancer activity of boron‐containing and structurally diverse small molecules in 4T1 breast cancer and Caco‐2 colon adenocarcinoma cells. Initial screening showed that five boronic acids lacked significant cytotoxicity, underscoring the structural specificity required for boron‐mediated bioactivity.
Azmi Yerlikaya +2 more
wiley +1 more source
Cancer Management and Research, 2020 Jun Liu,1 Guang Feng,2 Zhengwei Li,3 Rui Li,1 Peng Xia1 1Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130000, People’s Republic of China; 2The Fourth Medical Center of PLA General Hospital, Beijing 100048 ...
Liu J, Feng G, Li Z, Li R, Xia P
doaj
Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]
, 2010 Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core +2 more sources
The study of hdac4 gene expression pattern after endurance exercises in animal model [PDF]
, 2017 زمینه و هدف: بیشتر تغییرات ایجاد شده در اثر فعالیت های بدنی طی روند اپی ژنیک رخ می دهد که فاکتور رونویسی HDAC4 در این روند نقش محوری بازی می کند. بنابراین هدف این پژوهش بررسی اثر یک دوره فعالیت استقامتی بر بیان ژن hdac4 در عضلات کند و تند انقباض بود. روش
Fathi, M.
core +1 more source
The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]
, 2018 Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi +12 more
core +2 more sources
Journal of Inflammation Research, 2021 Chen-miao Huang,1,2 Jia-jing Cai,1,2 Shao-wu Jin,1,2 Qi-cheng Lin,1,2 Qian-juan Fang,1,2 Ke Nan,1,2 Yuan Han,1,2 Wen-wei Ge,1,2 Yu Liu,1,2 Yuan-xiang Tao,1,3 Hong Cao,1,2 Jun Li1,2 1Department of Anesthesiology and Perioperative Medicine, The Second ...
Huang C +11 more
doaj