Results 201 to 210 of about 81,753 (307)

HDAC1 acts as a tumor suppressor in ALK-positive anaplastic large cell lymphoma: implications for HDAC inhibitor therapy. [PDF]

Leukemia
Zrimšek M, Draganić K, Malzer A, Doblmayr V, Mišura K, de Freitas E Silva R, Matthews JD, Iannelli F, Wohlhaupter S, Pérez Malla CU, Fischer H, Schachner H, Schiefer AI, Sheibani-Tezerji R, Chiarle R, Turner SD, Ellmeier W, Seiser C, Egger G.   +18 more
europepmc   +1 more source

CD47 blockade reverses resistance to HDAC inhibitor by liberating anti-tumor capacity of macrophages. [PDF]

J Exp Clin Cancer Res
Xu X, Wang Q, Guo K, Xu J, Lu Y, Chen H, Hu W, Fu Y, Sun L, He Y, Chen Z, Xia W, Pan M, Lin B, Yang W, Wang Q, Wen Z, Cao Q, Xiao P.   +18 more
europepmc   +1 more source

Neurogenesis and the Epigenetic Landscape: Role of Histone Modifications and Chromatin Remodeling

Brain and Behavior, Volume 16, Issue 2, February 2026.
Histone methylation and acetylation modulate gene expression by inducing chromatin condensation or relaxation, which in turn regulates transcriptional activity and impacts neurogenesis. ABSTRACT Aims The purpose of this review is to examine how epigenetic regulation particularly chromatin modification and histone methylation controls gene expression ...
Degisew Yinur Mengistu, Biniam Moges Eskeziyaw   +1 more
wiley   +1 more source

HDAC inhibitor (SAHA) enhances B7-H3-specific CAR T cell cytotoxic efficacy against chondrosarcoma cells and prolongs survival in an orthotopic mouse model. [PDF]

Transl Oncol
Osei-Hwedieh DO, He L, Wang K, Fan S, Ferrone S, Wang X, Schwab JH.   +6 more
europepmc   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

The hydroxamate based HDAC inhibitor WMJ-J-09 induces colorectal cancer cell death by targeting tubulin and downregulating survivin. [PDF]

Sci Rep
Huang YH, Huang YM, Huang WJ, Yu MC, Chuang CH, Hsu YF, Chen HC, Chen LC, Huang SW, Hsu MJ.   +9 more
europepmc   +1 more source

Rare DMD Gene Duplication in a Lebanese Child With Duchene Muscular Dystrophy

Clinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT A five‐year‐old boy with clinical features of Duchenne muscular dystrophy was found to have a rare de novo DMD exon 2–9 duplication. Reporting such atypical duplications improves genotype–phenotype interpretation and highlights the need for multidisciplinary care, particularly in resource‐limited settings.
Nada Assaf, Jeanette El Hajj, Jana Doghman, Fatima Hussein, Simone Khalifeh   +4 more
wiley   +1 more source

Combination of HDAC inhibitor and PI3K inhibitor suppresses autophagy and induces apoptosis via cytoplasmic IκBα stabilization in p53-mutant diffuse large B-cell lymphoma. [PDF]

Cell Death Discov
Yao J, Li M, Jiang Y, Yao N, Liu Y, Lv L, Li Y, Huang J, Zha J, Xu B.   +9 more
europepmc   +1 more source

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu, Yuzhu Ma, Yueying Gao, Yao Chen, Xinyu Li, Yue Wu, Meiling Sun, Qizhao Li, Yanhong Zhao, Shuqian Xu, Shengjin Fan, Yongsheng Li, Huitao Fan   +12 more
wiley   +1 more source

Enhancing HDAC Inhibitor Screening: Addressing Zinc Parameterization and Ligand Protonation in Docking Studies. [PDF]

Int J Mol Sci
Buccheri R, Coco A, Pasquinucci L, Amata E, Marrazzo A, Rescifina A.   +5 more
europepmc   +1 more source