Results 211 to 220 of about 81,753 (307)

HDAC Inhibitor OBP-801 [PDF]

, 2020
openaire   +1 more source

T‐cell exhaustion from a multiomics perspective: Differentiation mechanisms and regulatory networks in the journey from progenitor‐Exhausted T cells to terminally exhausted T cells

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
(1) Core Process: Persistent antigen, from TDLNs to TME, drives Tpex → Tex‐int → Tex‐term differentiation. (2) Multiomics Regulation: This fate transition is orchestrated by a co‐ordinated, multi‐layered molecular network. (3) Functional Outcome: Dysregulated signalling and surging co‐inhibitory receptors lock in proliferative arrest and functional ...
Tong Zhu, Xiaoyu Teng, Qinlian Jiao, Yidan Ren, Yunshan Wang, Maoxiao Feng   +5 more
wiley   +1 more source

Cutaneous T-Cell Lymphoma: Yin-Yang Effects of Transcription Factors HLF and NFIL3 in Regulation of Malignant T-Cell Markers in the Context of HDAC Inhibitor Romidepsin Treatment. [PDF]

Cancers (Basel)
Kossenkov AV, Dawany N, Majumdar S, Chang C, Nichols C, Wysocka M, Piekarz R, Showe MK, Bates SE, Rook AH, Kim EJ, Showe LC.   +11 more
europepmc   +1 more source

HDAC inhibitors as radiosensitizers

HDAC inhibitors as radiosensitizers
Radiation therapy is one of the main anticancer therapies. However, there are considerable numbers of radioresistant carcinoma cells and severe adverse effects occasionally occur after radiation therapy. Therefore, there have been many attempts to identify radiosensitizers.
openaire  

Salvia coccinea and Apigenin: A Natural Treasure of Lamiaceae in Pharmacological Innovation

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Salvia coccinea is rich in bioactive phytochemicals, notably the flavonoid apigenin, offering strong antioxidant, anti‐inflammatory, and antimicrobial effects. By modulating inflammatory and oxidative pathways, it shows potential for managing chronic diseases.
Muhammad Usman Khalid, Muhammad Tauseef Sultan, Muhammad Maaz, Shehnshah Zafar, Anum Shoukat, Nudrat Khursheed, Matteo Bordiga, Amna Junaid   +7 more
wiley   +1 more source

HDAC inhibitor SAHA enhances antitumor immunity via the HDAC1/JAK1/FGL1 axis in lung adenocarcinoma. [PDF]

J Immunother Cancer
Xu T, Fang Y, Gu Y, Xu D, Hu T, Yu T, Xu YY, Shen HY, Ma P, Shu Y.   +9 more
europepmc   +1 more source

From Coffee Alkaloid to Ovarian Targets: An Integrated Computational Framework for Trigonelline in Ovarian Aging

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
This study employs an integrative in silico approach combining network pharmacology, molecular docking, and molecular dynamics simulations to explore the molecular association between trigonelline and ovarian aging, identifying five hub proteins (MMP9, JAK2, PARP1, HDAC1, and CYP3A4) and three major mechanistic axes related to extracellular matrix ...
Woon Shin Yong, Yuankun Han, Yulu Shen, Ningyu Sun, Qinhua Zhang   +4 more
wiley   +1 more source

A Novel Class I HDAC Inhibitor, AW01178, Inhibits Epithelial-Mesenchymal Transition and Metastasis of Breast Cancer. [PDF]

Int J Mol Sci
Liu X, Chen Y, Li Y, Shen Y, Dong S, Tan J.   +5 more
europepmc   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Inhibition of glutaminolysis alone and in combination with HDAC inhibitor has anti-myeloma therapeutic effects. [PDF]

Cancer Drug Resist
Okabe S, Tanaka Y, Moriyama M, Gotoh A.
europepmc   +1 more source