Results 101 to 110 of about 337,632 (303)

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

From Mixing methods to the logic(s) of inquiry: taking a fresh look at developing mixed design studies

Health Psychology and Behavioral Medicine, 2018
Objective: This invited paper offers an innovative framework for mixed methods research design. Method: We propose the adoption of the Model of Disciplined Inquiry, a five-component model that focuses on the research question(s) rather than the type(s ...
Rachel L. Shaw, David R. Hiles, Karen West, Carol Holland, Holly Gwyther   +4 more
doaj   +1 more source

Healthy ageing of cloned sheep [PDF]

, 2016
The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases.
A Ogura, AJ Rathbone, AJF Russel, AZ Lalia, B Alexander, C Zilkens, CL Adam, D Lister, D Mattheeuws, DN Wells, DS Gardner, EN Bergman, F Han, G Bianchi, G Lazaraviciute, H Niemann, I Choi, I Wilmut, J Kaler, J-M Vandeweerd, JB Cibelli, JC Guerra, JH Kellgren, JH Lee, JJ Curtis, JJ Robinson, JP McCann, JR Hill, JR Hill, K Kirchhoff, K Takahashi, KD Sinclair, KL Tamashiro, L Lai, LE Young, LK Dahl, M Panarace, M Tachibana, M Yamada, MH Forouzanfar, N Ogonuki, N Williams, N Williams, O Dyer, P Narbonne, P Rhodes, PD Gluckman, PG Shiels, PM Kearney, PR Scott, PR Scott, RA Gonzalez-Villalobos, RA Gonzalez-Villalobos, RM Marion, RP Lanza, RP Lanza, RP Steegers-Theunissen, RT Cowan, S Glyn-Jones, S Thysen, S Watanabe, S,T Kalinowski, SD Crowley, SM Rhind, SV Eastwood, T Wakayama, WJ Gordon, Y Heyman, YG Chung   +68 more
core   +2 more sources

Gemcitabine, Docetaxel, Melphalan, Carboplatin as Part of Sequential Cycles of High‐Dose Chemotherapy With Autologous Hematopoietic Stem‐Cell Rescue for Multiply Relapsed/Refractory Pediatric Germ Cell Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost, Olayinka Okeleji, Amr Elgehiny, Douglas Harrison, Cynthia Herzog, Jeremy Connors, Demetrios Petropoulos, Priti Tewari, Dristhi Ragoonanan, Yago Nieto, Irtiza N. Sheikh   +10 more
wiley   +1 more source

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Insights into salt perception and cognitive impairment among middle-aged and older adults: a scoping review

BMC Public Health
Background A decline in taste sensitivity from aging leads people with a higher salt threshold to frequently add more salt to their food, which attributed to decreased cognitive efficiency.
Azira Sazali, Suzana Shahar, Hasnah Haron, Nor Fadilah Rajab, Fatin Hanani Mazri, Theng Choon Ooi, Nurul Fatin Malek Rivan   +6 more
doaj   +1 more source

The effects of inspiratory muscle training in older adults [PDF]

, 2015
Purpose: Declining inspiratory muscle function and structure and systemic low-level inflammation and oxidative stress may contribute to morbidity and mortality during normal ageing.
Aznar-Lain, Belman, Borg, Bowling, Brooks, Bruunsgaard, Carey, Davis, DEAN E. MILLS, Dennis, Downey, Enright, Falaschetti, Febbraio, Freedman, Garcia-Rio, GRAHAM R. SHARPE, Greig, Ho, Huang, Huang, Illi, Jensen, Johnson, Johnson, Kharraz, Kregel, Kumar, Kyle, MICHAEL A. JOHNSON, Miller, Mills, Mills, Murphy, Phillips, Polkey, Ramirez-Sarmiento, Robertson, Romer, Romer, Takahashi, Tidball, Troosters, Washburn, Watsford, WILLIAM H. T. SMITH, Wolsk, YVONNE A. BARNETT   +47 more
core   +1 more source

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

Outcomes and Surgical Management of Malignant Rhabdoid Tumor of the Kidney: A Report From the Pediatric Surgical Oncology Research Collaborative

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt, Elisabeth T. Tracy, Anghela Paredes, Catherine Beckhorn, Harold J. Leraas, Joseph Fusco, Katlyn G. McKay, Nelly‐Ange T. Kontchou, Zachary J. Kastenberg, David W. Hoyt, Jonathan Roach, Emily K. Myers, Nicholas G. Cost, Bhargava Mullapudi, Charles R. Marchese, Amanda R. Jensen, Timothy B. Lautz, Michela Carter, Roshni Dasgupta, John Lundstedt, Joseph G. Brungardt, Lindsay Talbot, Andrew M. Davidoff, Andrew J. Murphy, Jennifer H. Aldrink, Sara Mansfield, Nelson Piche, Annie Le‐Nguyen, Dave R. Lal, Brian T. Craig, Jennifer M. Schuh, Barrett P. Cromeens, Sindhu Mannava, Shannon Castle, Adriana Lopez, Kelsey Mello, Joshua Short, Robin T. Petroze, Shay Rajaval, Grace R. Thompson, Peter Mattei, David H. Rothstein, Elizabeth Fialkowski, Kathryn Fowler, Nathan Martchenke, Barrie S. Rich, Richard D. Glick, Erin G. Brown, Kathleen Doyle, Paige Abril, Natashia Seemann, Jacob Davidson, Claire A. Wilson, Hau D. Le, Devashish Joshi, Michael Stellon, Tamer Ahmed, Alexandra Dimmer, Peter F. Ehrlich, Maya Hammoud, Keyonna Williams, Christa N. Grant, Merit Gorgy, Stephanie F. Polites, Julia Debertin, Danielle B. Cameron, Alyssa Stetson, Eugene S. Kim, William G. Lee, Aaron Barkhordar, Mary Austin, Brian A. Coakley, Anastasia Kahan, Joseph T. Murphy, Michael Pitonak, Chloé Boehmer, Marcus M. Malek   +76 more
wiley   +1 more source

Dynamic transitions in falls and physical activity among older adults in Malaysia: a longitudinal multi-state analysis

BMC Public Health
Objective In this study, we examined the longitudinal trajectories of falls and physical activity statuses among older adults and identified factors associated with state transitions.
Theng Choon Ooi, Nurul Fatin Malek Rivan, Suzana Shahar, Devinder Kaur Ajit Singh   +3 more
doaj   +1 more source