Results 111 to 120 of about 338,464 (302)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans

Communications Biology
Aging leads to age-related pathology that causes death, and genes affect lifespan by determining such pathology. Here we investigate how age-related pathology mediates the effect of genetic and environmental interventions on lifespan in C.
Carina C. Kern, Petru Manescu, Matt Cuffaro, Catherine Au, Aihan Zhang, Hongyuan Wang, Ann F. Gilliat, Sophie van Schelt, Marina Ezcurra, David Gems   +9 more
doaj   +1 more source

On the Semantic of Ageing: from Successful Ageing to Dynamic and Developmental Model of Ageing [PDF]

, 2017
During the second part of Twentieth Century worldwide there has been an important process of conceptualization on active ageing and healthy ageing, related to the progressive ageing of population in most of the countries, the so called “Demographic ...
Gaviano, L., Petretto, D.R., Pili, L., Pili, R   +3 more
core  

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Colony level fitness analysis identifies a trade-off between population growth rate and dauer yield in Caenorhabditis elegans

BMC Ecology and Evolution
Background In the evolution from unicellular to multicellular life forms, natural selection favored reduced cell proliferation and even programmed cell death if this increased organismal fitness.
Hannah Chapman, Kuei Ching Hsiung, Isadora Rawlinson, Evgeniy R. Galimov, David Gems   +4 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Limited health literacy increases the likelihood of cognitive frailty among older adults

BMC Geriatrics
Background Cognitive frailty is a dual geriatric syndrome that is preventable with lifestyle changes. Lifestyle changes are influenced by literacy level.
Jamilah Mohammad Hanipah, Arimi Fitri Mat Ludin, Devinder Kaur Ajit Singh, Ponnusamy Subramaniam, Suzana Shahar   +4 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Healthy Ageing

, 2018
The essence of accessibility in combination with a family care approach was ...
Christine Stephens, Mary Breheny
  +4 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source