Results 41 to 50 of about 274,892 (263)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

RNAi based transcriptome suggests genes potentially regulated by HSF1 in the Pacific oyster Crassostrea gigas under thermal stress

BMC Genomics, 2019
Background The Pacific oyster Crassostrea gigas is an important fishery resource that is sensitive to temperature fluctuations. Thus, it has evolved a protection mechanism against heat stress by increasing the expression of the gene coding for heat shock
Youli Liu, Li Li, Baoyu Huang, Wei Wang, Guofan Zhang   +4 more
doaj   +1 more source

Acute high temperature exposure impairs hypoxia tolerance in an intertidal fish.

PLoS ONE, 2020
Acute heat shock has previously been shown to improve subsequent low O2 (hypoxia) tolerance in an intertidal fish species, a process known as cross-tolerance, but it is not known whether this is a widespread phenomenon. This study examined whether a rock
Tristan J McArley, Anthony J R Hickey, Neill A Herbert   +2 more
doaj   +1 more source

BH3-only protein BIM mediates heat shock-induced apoptosis. [PDF]

PLoS ONE, 2014
Acute heat shock can induce apoptosis through a canonical pathway involving the upstream activation of caspase-2, followed by BID cleavage and stimulation of the intrinsic pathway.
Indra M Mahajan, Miao-Der Chen, Israel Muro, John D Robertson, Casey W Wright, Shawn B Bratton   +5 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Heat transfer foot print on ceramics after thermal shock with droplet impingement: Development of thermal shock tolerant material with hydrophobic surface

AIP Advances, 2018
We perform a systematic study of the thermal shock experienced by the alumina during quenching by cold water droplet impingement with heated surface temperature ranging from 125°C to 475°C for Weber number ≈32.
Divya J. Prakash, Youho Lee
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance

Cell Reports
Summary: Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular intestinal infection and proteotoxic stress and that promotes ...
Mario Bardan Sarmiento, Spencer S. Gang, Patricija van Oosten-Hawle, Emily R. Troemel   +3 more
doaj   +1 more source

Transcriptome analysis of Clematis lanuginosa: Novel features of the molecular events occurring under heat-shock stress

Ornamental Plant Research, 2022
The weak heat tolerance of Clematis ornamental varieties negatively affects their ornamental qualities in the summer. To elucidate heat resistance mechanisms, Clematis lanuginosa, which is an important original parent of the Clematis large-flowered group
Linfang Li, Shuan Wang, Qiao Li, Linghe Sun, Xin Han, Lulu Gao, Peng Wang, Fenni Lv, Rutong Yang, Ya Li   +9 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source