Results 41 to 50 of about 3,954,936 (346)
Drosophila heat shock response requires the jnk pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif [PDF]
, 2012 Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Garlena, RA, Gonda, RL, Stronach, B
core +8 more sources
BMC Genomics, 2009 Background The thermotolerance of Aspergillus fumigatus plays a critical role in mammalian and avian infections. Thus, the identification of its adaptation mechanism to higher temperature is very important for an efficient anti-fungal drug development as
Miyano Satoru +2 more
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Heat shock protein 90 has roles in intracellular calcium homeostasis, protein tyrosine phosphorylation regulation, and progesterone-responsive sperm function in human sperm. [PDF]
PLoS ONE, 2014 Heat shock protein 90 plays critical roles in client protein maturation, signal transduction, protein folding and degradation, and morphological evolution; however, its function in human sperm is not fully understood.
Kun Li +7 more
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Frontiers in Microbiology, 2022 The ability of bacteria to resist heat shock allows them to adapt to different environments. In addition, heat shock resistance is known for their virulence.
Bingzhou Zhang +16 more
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
HeliyonHeat shock, a transient exposure to high temperatures, is a substantial hazard to rice (Oryza sativa L.) production and sustainability. The objective of this review paper is to summarize the impact of heat shock on rice and explore approaches to mitigate
Mohammad Mobarak Hossain +3 more
doaj +1 more source
Transcriptomic Adaptation of Legionella pneumophila to Transient Heat Shock
Frontiers in Water, 2022 A natural inhabitant of freshwater microbial ecology, Legionella pneumophila is an opportunistically pathogenic bacteria that has found a niche in hot water distribution systems (HWDS) where it challenges hospitals with the spread of nosocomial infection.
Jeffrey Liang, Sebastien P. Faucher
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Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]
, 2015 Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A. +3 more
core +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Heat Shock Related Protein Expression in Abdominal Testes of Asian Elephant (Elephas maximus)
AnimalsThe abdominal testes of Asian elephants show normal spermatogenesis. Heat shock in cryptorchid testes elevates heat shock factor (HSF) expression, leading to germ cell apoptosis, while increased heat shock proteins (HSPs) levels provide protection.
Yoko Sato +10 more
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