The Emerging Role of Heat Shock Factor 1 (HSF1) and Heat Shock Proteins (HSPs) in Ferroptosis [PDF]
Pathophysiology, 2023 Cells employ a well-preserved physiological stress response mechanism, termed the heat shock response, to activate a certain type of molecular chaperone called heat shock proteins (HSPs).
Iman Aolymat +2 more
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Nanoparticle-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation [PDF]
Nature Communications, 2023 The survival of malignant tumors is highly dependent on their intrinsic self-defense pathways such as heat shock protein (HSP) during cancer therapy. However, precisely dismantling self-defenses to amplify antitumor potency remains unexplored. Herein, we
Ting Li +9 more
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response [PDF]
Cell Reports, 2023 Summary: Despite its pivotal roles in biology, how the transcriptional activity of c-MYC is tuned quantitatively remains poorly defined. Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts ...
Meng Xu +8 more
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Cancer-Associated Fibroblasts Promote Aggressive Gastric Cancer Phenotypes via Heat Shock Factor 1-Mediated Secretion of Extracellular Vesicles. [PDF]
Cancer Res, 2021 This study shows how HSF1 regulates a stromal transcriptional program associated with aggressive gastric cancer and identifies multiple proteins within this program as candidates for therapeutic intervention.
Grunberg N +19 more
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Diversification of the Caenorhabditis heat shock response by Helitron transposable elements [PDF]
eLife, 2019 Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression of genes important for cellular protection during this stress ...
Jacob M Garrigues +3 more
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Regulation of the mammalian heat shock factor 1 [PDF]
The FEBS Journal, 2017 Living organisms are endowed with the capability to tackle various forms of cellular stress due to the presence of molecular chaperone machinery complexes that are ubiquitous throughout the cell. During conditions of proteotoxic stress, the transcription
Dayalan Naidu, Sharadha +1 more
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Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1 [PDF]
Frontiers in Cardiovascular Medicine, 2023 Atherosclerosis is a major risk factor for cardiovascular diseases. Hypercholesterolemia has been both clinically and experimentally linked to cardiovascular disease and is involved in the initiation of atherosclerosis.
Shruti Ghai, Alex Young, Kuo-Hui Su
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The stress-responsive kinase DYRK2 activates heat shock factor 1 promoting resistance to proteotoxic stress. [PDF]
Cell Death Differ, 2021 To survive proteotoxic stress, cancer cells activate the proteotoxic-stress response pathway, which is controlled by the transcription factor heat shock factor 1 (HSF1).
Moreno R +8 more
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Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington’s disease [PDF]
Cell Reports, 2023 Summary: p53 and HSF1 are two major transcription factors involved in cell proliferation and apoptosis, whose dysregulation contributes to cancer and neurodegeneration.
Rachel H. Mansky +9 more
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Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. [PDF]
Nat Commun, 2020 In the colon, long-term exposure to chronic inflammation drives colitis-associated colon cancer (CAC) in patients with inflammatory bowel disease.
Levi-Galibov O +19 more
europepmc +2 more sources