Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA. [PDF]
EMBO J, 2020 The heat shock response is a universal transcriptional response to proteotoxic stress orchestrated by heat shock transcription factor Hsf1 in all eukaryotic cells.
Kmiecik SW, Le Breton L, Mayer MP.
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Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases [PDF]
Molecular and Cellular Biology, 2016 Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
Benjamin, Ivor J +13 more
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HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes. [PDF]
Int J Mol Sci, 2019 HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also called heat ...
Kovács D +7 more
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Heat Shock Factor 1 as a Prognostic and Diagnostic Biomarker of Gastric Cancer [PDF]
Biomedicines, 2021 Identification of effective prognostic and diagnostic biomarkers is needed to improve the diagnosis and treatment of gastric cancer. Early detection of gastric cancer through diagnostic markers can help establish effective treatments. Heat shock factor 1
Woong Kim, Seok-Jun Kim
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Heat Shock Factor 1 Prevents Age-Related Hearing Loss by Decreasing Endoplasmic Reticulum Stress [PDF]
Cells, 2021 Endoplasmic reticulum (ER) stress is a common stress factor during the aging process. Heat shock factor 1 (HSF1) plays a critical role in ER stress; however, its exact function in age-related hearing loss (ARHL) has not been fully elucidated. The purpose
Yun Yeong Lee +5 more
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Pro-death signaling of cytoprotective heat shock factor 1: upregulation of NOXA leading to apoptosis in heat-sensitive cells. [PDF]
Cell Death Differ, 2020 Heat shock can induce either cytoprotective mechanisms or cell death. We found that in certain human and mouse cells, including spermatocytes, activated heat shock factor 1 (HSF1) binds to sequences located in the intron(s) of the PMAIP1 (NOXA) gene and ...
Janus P +11 more
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Heat shock factor 1 is a direct anti-amyloid factor: connecting neurodegeneration and uncontrolled growth [PDF]
Neural Regeneration Research, 2022 Zijian Tang, Chengkai Dai
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Mechanistic Insights Into Oxidative Response of Heat Shock Factor 1 Condensates [PDF]
JACS AuSoichiro Kawagoe +6 more
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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase. [PDF]
Mol Cell, 2019 Su KH, Dai S, Tang Z, Xu M, Dai C.
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Transcription regulation of HYPK by Heat Shock Factor 1. [PDF]
PLoS ONE, 2014 HYPK (Huntingtin Yeast Partner K) was originally identified by yeast two-hybrid assay as an interactor of Huntingtin, the protein mutated in Huntington's disease.
Srijit Das, Nitai Pada Bhattacharyya
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