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Chilo suppressalis heat shock proteins are regulated by heat shock factor 1 during heat stress
Insect Molecular Biology, 2022Abstract Heat shock factor 1 (HSF1) functions to maintain cellular and organismal homeostasis by regulating the expression of target genes, including those encoding heat shock proteins (HSPs). In the present study, the gene encoding HSF1 was cloned from the rice pest Chilo suppressalis
Chuan‐Lei Dong +3 more
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Roles of heat shock factor 1 beyond the heat shock response
Cellular and Molecular Life Sciences, 2018Various stress factors leading to protein damage induce the activation of an evolutionarily conserved cell protective mechanism, the heat shock response (HSR), to maintain protein homeostasis in virtually all eukaryotic cells. Heat shock factor 1 (HSF1) plays a central role in the HSR. HSF1 was initially known as a transcription factor that upregulates
Barna János +2 more
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Role of Heat Shock Transcriptional Factor 1 and Heat Shock Proteins in Cardiac Hypertrophy
Trends in Cardiovascular Medicine, 2008Cardiac hypertrophy is an independent risk factor for cardiovascular disease. Initially, cardiac hypertrophy is an adaptive response to increased wall stress, but sustained stress leads to heart failure. It remains unclear how the transition from adaptive cardiac hypertrophy to maladaptive cardiac hypertrophy occurs.
Haruhiro, Toko +2 more
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Journal of Critical Care, 2008
Sepsis, endotoxin tolerance, and heat shock (HS) all display down-regulation of innate immunity. We hypothesize that HS factor 1 (HSF-1) induces competitive inhibition of nuclear factor-kappaB (NF-kappaB)-induced signal transduction in both endotoxin tolerance and HS.We compared endotoxin tolerance and HS in RAW 264.7 cells.
Mingchen, Song +2 more
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Sepsis, endotoxin tolerance, and heat shock (HS) all display down-regulation of innate immunity. We hypothesize that HS factor 1 (HSF-1) induces competitive inhibition of nuclear factor-kappaB (NF-kappaB)-induced signal transduction in both endotoxin tolerance and HS.We compared endotoxin tolerance and HS in RAW 264.7 cells.
Mingchen, Song +2 more
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Heat Shock Inhibits Activation of NF-κB in the Absence of Heat Shock Factor-1
Biochemical and Biophysical Research Communications, 2002The heat shock response is known to inhibit NF-kappaB activation and NF-kappaB-dependent gene expression. Herein we determined if cells lacking heat shock factor-1 (HSF-1), the major transcription factor regulating heat shock protein gene expression, have an altered ability to modulate NF-kappaB activation.
Vivek, Malhotra +5 more
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Critical Care Medicine, 2002
Life-threatening conditions cause severe changes in the organization and conformation of macromolecules, creating urgent requirements for protein repair to ensure survival. As molecular chaperones, heat shock proteins (HSP) that have specialized functions in protein folding are now well established to restore homeostasis in cells and organisms ...
Elisabeth S., Christians +2 more
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Life-threatening conditions cause severe changes in the organization and conformation of macromolecules, creating urgent requirements for protein repair to ensure survival. As molecular chaperones, heat shock proteins (HSP) that have specialized functions in protein folding are now well established to restore homeostasis in cells and organisms ...
Elisabeth S., Christians +2 more
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Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart
American Journal of Physiology-Heart and Circulatory Physiology, 2001Heat-shock proteins (HSPs) are an important family of endogenous, protective proteins. Overexpression of HSPs is protective against cardiac injury. Previously, we observed that dexamethasone activated heat-shock factor-1 (HSF-1) and induced a 60% increase in HSP72 in adult cardiac myocytes.
A A, Knowlton, L, Sun
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Role of Heat Shock Factor 1 in HIV
2020Introduction Viral infection is one of the triggers to heat shock response which is an evolutionarily conserved cell protection mechanism in eukaryotic cells and is closely related to the key transcriptional factor heat shock factor 1 (HSF1). It is generally recognized that HSF1 and its downstream factors especially heat shock proteins play extensive ...
Xinfeng Xu, Xiaoyan Pan, Shuwen Liu
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Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock
Molecular Brain Research, 1995Recently, many studies have demonstrated the induction of stress proteins in the mammalian nervous system under various pathological conditions. These altered genetic programs may function to protect individual cells against stressful conditions. However, little is known about the molecular mechanisms regulating these stress responses in animals.
T, Higashi +4 more
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Heat shock factor 1 prevents the reduction in thrashing due to heat shock in Caenorhabditis elegans
Biochemical and Biophysical Research Communications, 2015Heat shock factor 1 (HSF-1) is activated by heat stress and induces the expression of heat shock proteins. However, the role of HSF-1 in thermotolerance remains unclear. We previously reported that heat stress reversibly reduces thrashing movement in Caenorhabditis elegans.
Tsubasa, Furuhashi, Kazuichi, Sakamoto
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