Results 271 to 280 of about 543,466 (295)

Expression and Purification of Human Heat-Shock Transcription Factor 1

Protein Expression and Purification, 1997
Heat-shock factor 1 (HSF1) is a 57-kDa cytoplasmic protein which binds to the promoters of heat-shock genes and activates transcription during heat shock. We describe here the expression and purification of the 529 amino acids form of human HSF1. We designed a new and complete purification protocol involving ammonium sulfate precipitation, heparin ...
Soncin, Fabrice, Prevelige, Robert, Calderwood, Stuart   +2 more
openaire   +3 more sources

Simvastatin induces heat shock factor 1 in vascular endothelial cells

Atherosclerosis, 2006
Statins not only reduce serum cholesterol but they also improve vascular endothelial function independent of their lipid-lowering effects. However, except for the mechanism of nitric oxide induction via calveolin, the physiologic basis for the pleiotropic effect of statins remains unknown.
Tsuyoshi, Uchiyama, Hiroyuki, Atsuta, Toshihiro, Utsugi, Yoshio, Ohyama, Tetsuya, Nakamura, Akira, Nakai, Masanori, Nakata, Ikuro, Maruyama, Hideaki, Tomura, Fumikazu, Okajima, Shoichi, Tomono, Shoji, Kawazu, Ryozo, Nagai, Masahiko, Kurarbayashi   +13 more
openaire   +2 more sources

HEAT SHOCK FACTOR 1

Pancreas, 2007
V. Dudeja, R. Chugh, Y. Yokoyama, R. Talukdar, D. Borja-Cacho, P. Zwolak, R. Dawra, S. Vickers, A. Saluja   +8 more
openaire   +1 more source

Heat Shock Factor 1 Governs Sleep-Wake Cycles Across Species

AbstractHeat Shock Factor 1 (HSF1) is a critical transcription factor for cellular proteostasis, but its role in sleep regulation remains unexplored. We demonstrate that nuclear HSF1 levels in the mouse brain fluctuate with sleep-wake cycles, increasing during extended wakefulness and decreasing during sleep.
Shintaro Yamazaki, Utham K. Valekunja, Jing Chen-Roetling, Akhilesh B. Reddy   +3 more
openaire   +2 more sources

Heat shock factors: integrators of cell stress, development and lifespan

Nature Reviews Molecular Cell Biology, 2010
Richard I Morimoto, Lea Sistonen
exaly  

Regulation of heat shock transcription factors and their roles in physiology and disease

Nature Reviews Molecular Cell Biology, 2017
Rocio Gomez-Pastor, Dennis J Thiele
exaly  

Role of the Major Heat Shock Proteins as Molecular Chaperones

Annual Review of Cell Biology, 1993
C Georgopoulos
exaly  

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

Nature Reviews Drug Discovery, 2011
Daniel W Neef, Dennis J Thiele
exaly  

Heat shock proteins as regulators of the immune response

Lancet, The, 2003
Alan Graham Pockley
exaly  

Stress-induced oligomerization and chromosomal relocalization of heat-shock factor

Nature, 1991
Joachim Clos
exaly