Results 21 to 30 of about 650,866 (279)

Protein kinase A binds and activates heat shock factor 1. [PDF]

PLoS ONE, 2010
Many inducible transcription factors are regulated through batteries of posttranslational modifications that couple their activity to inducing stimuli.
Ayesha Murshid, Shiuh-Dih Chou, Thomas Prince, Yue Zhang, Ajit Bharti, Stuart K Calderwood   +5 more
doaj   +1 more source

Is there a role for HSF1 in viral infections?

FEBS Open Bio, 2022
Cells undergo numerous processes to adapt to new challenging conditions and stressors. Heat stress is regulated by a family of heat shock factors (HSFs) that initiate a heat shock response by upregulating the expression of heat shock proteins (HSPs ...
Antonia Reyes, Areli J. Navarro, Benjamín Diethelm‐Varela, Alexis M. Kalergis, Pablo A. González   +4 more
doaj   +1 more source

Aneuploidy and proteotoxic stress in cancer [PDF]

, 2015
Although nearly ubiquitous in cancer, aneuploidy exerts detrimental effects on human cells. We recently demonstrated that aneuploid human cells exhibit impaired heat shock factor protein 1 (HSF1) and HSP90 function, suggesting a functional link between ...
Donnelly, N., Storchova, Z.
core   +2 more sources

Compound A, a selective glucocorticoid receptor modulator, enhances heat shock protein Hsp70 gene promoter activation [PDF]

, 2013
Compound A possesses glucocorticoid receptor (GR)-dependent anti-inflammatory properties. Just like classical GR ligands, Compound A can repress NF-kappa B-mediated gene expression.
Bahar, Ali A, Beck, Ilse, Bougarne, Nadia, Bracke, Marc, Clarisse, Dorien, De Bosscher, Karolien, Declercq, Wim, Denecker, Geertrui, Desmet, Sofie, Devos, Michael, Drebert, Zuzanna, Gevaert, Kris, Gossye, Valerie, Haegeman, Guy, Hoya-Arias, Ruben, Lievens, Sam, Ruttens, Bart, Tavernier, Jan, Vanden Berghe, Wim   +18 more
core   +9 more sources

Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]

, 2019
Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong, dongyeop lee, Eunseok choi, Jang, SK, Lee, SJ, Seo, K   +5 more
core   +1 more source

Immunolocalization of anti-hsf1 to the acetabular glands of infectious schistosomes suggests a non-transcriptional function for this transcriptional activator. [PDF]

PLoS Neglected Tropical Diseases, 2014
Schistosomiasis is a chronically debilitating disease caused by parasitic worms of the genus Schistosoma, and it is a global problem affecting over 240 million people.
Kenji Ishida, Melissa Varrecchia, Giselle M Knudsen, Emmitt R Jolly   +3 more
doaj   +1 more source

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]

, 2008
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano, Borkowski, Andrew W., Heppner, Frank L., Hutter, Gregor, Jackson, Walter S., King, Oliver D., Lindquist, Susan, Raymond, Gregory J., Steele, Andrew D.   +8 more
core   +3 more sources

Dorsomorphin induces cancer cell apoptosis and sensitizes cancer cells to HSP90 and proteasome inhibitors by reducing nuclear heat shock factor 1 levels

Cancer Biology & Medicine, 2019
Objective Heat shock factor 1 (HSF1), a transcriptional regulator of heat shock proteins (HSPs), is an attractive therapeutic target for cancer. However, only a few HSF1 inhibitors have been identified so far.Methods The mRNA and protein levels of HSF1 ...
Na Li, Ting Wang, Zongmeng Li, Xiaoli Ye, Bo Deng, Shu Zhuo, Pengle Yao, Mengmei Yang, Hong Mei, Xiaofang Chen, Tengfei Zhu, Shiting Chen, Hui Wang, Jiming Wang, Yingying Le   +14 more
doaj   +1 more source

Inhibition of the Heat Shock Protein A (HSPA) Family Potentiates the Anticancer Effects of Manumycin A

Cells, 2021
Manumycin A (MA) is a well-tolerated natural antibiotic showing pleiotropic anticancer effects in various preclinical in vitro and in vivo models.
Damian Robert Sojka, Sylwia Hasterok, Natalia Vydra, Agnieszka Toma-Jonik, Anna Wieczorek, Agnieszka Gogler-Pigłowska, Dorota Scieglinska   +6 more
doaj   +1 more source

Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line

Journal of Inflammation, 2011
Poly (ADP-ribose) polymerase-1 (PARP-1) is a highly conserved multifunctional enzyme, and its catalytic activity is stimulated by DNA breaks. The activation of PARP-1 and subsequent depletion of nicotinamide adenine dinucleotide (NAD+) and adenosine ...
Zingarelli Basilia, Gefter Julia V, Sjodin Hanna, Aneja Rajesh K, Delude Russell L   +4 more
doaj   +1 more source