Transient intracellular acidification regulates the core transcriptional heat shock response
eLife, 2020 Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought ...
Catherine G Triandafillou +3 more
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Unraveling complex interplay between heat shock factor 1 and 2 splicing isoforms. [PDF]
PLoS ONE, 2013 Chaperone synthesis in response to proteotoxic stress is dependent on a family of transcription factors named heat shock factors (HSFs). The two main factors in this family, HSF1 and HSF2, are co-expressed in numerous tissues where they can interact and ...
Sylvain Lecomte +8 more
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Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis [PDF]
, 2018 Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated with massive protein ...
Airoldi, Edoardo M. +7 more
core +1 more source
Journal of Inflammation, 2005 Background Viruses remain one of the inducers of the stress response in the infected cells. Heat shock response induced by vaccinia virus (VV) infection was studied in vitro in human blood monocyte derived macrophages (MDMs) as blood cells usually ...
Dziedzic Jakub +4 more
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Manipulating heat shock factor-1 in Xenopus tadpoles: neuronal tissues are refractory to exogenous expression. [PDF]
PLoS ONE, 2010 BACKGROUND: The aging related decline of heat shock factor-1 (HSF1) signaling may be causally related to protein aggregation diseases. To model such disease, we tried to cripple HSF1 signaling in the Xenopus tadpole.
Ron P Dirks +4 more
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Tracking the Activation of Heat Shock Signaling in Cellular Protection and Damage
Cells, 2022 Heat Shock (HS) signaling is activated in response to various types of cellular stress. This activation serves to protect cells from immediate threats in the surrounding environment.
Shisui Torii, Pasko Rakic
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Hopf bifurcation in a gene regulatory network model: Molecular movement causes oscillations [PDF]
, 2015 Gene regulatory networks, i.e. DNA segments in a cell which interact with each other indirectly through their RNA and protein products, lie at the heart of many important intracellular signal transduction processes.
Chaplain, M, Ptashnyk, M, Sturrock, M
core +1 more source
The influence of potassium on core and geodynamo evolution [PDF]
, 2004 We model the thermal evolution of the core and mantle using a parametrized convection scheme, and calculate the entropy available to drive the geodynamo as a function of time.
Abramowitz +19 more
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Host proteostasis modulates influenza evolution
eLife, 2017 Predicting and constraining RNA virus evolution require understanding the molecular factors that define the mutational landscape accessible to these pathogens.
Angela M Phillips +9 more
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Comparative modeling and mutual docking of structurally uncharacterized heat shock protein 70 and heat shock factor-1 proteins in water buffalo [PDF]
Veterinary World, 2019 Aim: In this study, a wide range of in silico investigation of Bubalus bubalis (BB) heat shock protein 70 (HSP70) and heat shock factor-1 (HSF1) has been performed, ranging from sequence evaluation among species to homology modeling along with their ...
Ravinder Singh +7 more
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