Results 41 to 50 of about 650,866 (279)

Mechanisms of Hsp90 regulation [PDF]

, 2016
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of disparate client proteins. This implicates Hsp90 in diverse biological processes that require a variety of co-ordinated regulatory mechanisms to control its ...
Ahn, Akira, Ali, Ali, Amin, Ammirante, Anckar, Anckar, Azevedo, Bali, Bandhakavi, Bansal, Bansal, Bansal, Barlev, Bharadwaj, Blank, Boellmann, Bonizzi, Bonner, Broemer, Brown, Bruce, Budzynski, Bulman, Catlett, Chen, Chen, Chen, Chen, Cho, Chrisostomos Prodromou, Combates, Cotto, Csermely, Cunningham, da Silva Correia, Deb, Dunn, Echeverria, Ehret, Espinosa, Farkas, Field, Finka, Frey, Geiss-Friedlander, Gerondakis, Ghosh, Gomez, Grad, Graf, Gugasyan, Gupta, Hashikawa, Hashikawa, Heimberger, Hensold, Hessling, Hickey, Hietakangas, Holmberg, Holmberg, Holt, Horejsi, Hubert, Ito, Jakob, Johnson, Jurivich, Kadota, Kekatpure, Kettenbach, Kitagawa, Kline, Knauf, Kobayashi, Kugel, Legagneux, Lei, Leskovar, Li, Li, Lindquist, Lingelbach, Liu, Liu, Longshaw, Lu, Makhnevych, Martinez-Ruiz, Mayor, McConnell, McLaughlin, Meyer, Meyer, Meyer, Mitsiades, Miyata, Miyata, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Morimoto, Muller, Murphy, Murtagh, Napetschnig, Neef, Newton, Nieto-Sotelo, Oeckinghaus, Ogiso, Onuoha, Panaretou, Park, Pattaramanon, Pearl, Pearl, Pelham, Peteranderl, Picard, Pirkkala, Pittet, Pratt, Pratt, Prodromou, Prodromou, Prodromou, Prodromou, Prodromou, Qing, Quanz, Rabindran, Rebbe, Retzlaff, Retzlaff, Richter, Roe, Rutherford, Sakurai, Sbroggio, Scheufler, Schuler, Scroggins, Shamovsky, Shao, Shen, Shi, Shiau, Shirasu, Siligardi, Siligardi, Smale, Smith, Solier, Sorger, Sorger, Sorger, Southworth, Steensgaard, Stephanou, Stephanou, Taipale, Takahashi, Takai, Vaughan, Vaughan, Verghese, Voellmy, Voss, Vujanac, Wandinger, Wang, Weikl, Westerheide, Whitesell, Wiederrecht, Williams, Xiao, Xu, Xu, Yahara, Yamamoto, Yang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhong, Zhou, Zou, Zuehlke, Zuo, Zuo   +199 more
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Aspirin relieves the calcification of aortic smooth muscle cells by enhancing the heat shock response

Pharmaceutical Biology, 2022
Context Vascular calcification is a major complication of chronic renal failure, which has been identified as an active process partly driven by osteogenic transition of vascular smooth muscle cells (VSMCs).
Quanquan Shen, Qian Chen, Yang Liu, Xiang Xue, Xiaogang Shen, Qiang He, Guokun Wang, Fei Han   +7 more
doaj   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Science Translational Medicine, 2020
Pharmacological inhibition of a stress-protective transcription factor provides proof of concept for treatment of therapy-resistant cancer. Putting the heat on cancer Heat shock factor 1 is a transcription factor that helps protect healthy cells from ...
Bushu Dong, Alex M. Jaeger, Philip Hughes, David R. Loiselle, J. S. Hauck, Yao Fu, T. Haystead, Jiaoti Huang, Dennis J. Thiele   +8 more
semanticscholar   +1 more source

Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.

Molecular Therapy, 2018
Heat shock factor 1 (HSF1) generally exhibits its properties under stress conditions. In tumors, HSF1 has a pleiotropic feature in regulating growth, survival, and aggressiveness of cancer cells.
Jiaqiu Li, P. Song, T. Jiang, D. Dai, Han-ying Wang, Jie Sun, Liyuan Zhu, Wenxia Xu, Lifeng Feng, V. Shin, H. Morrison, Xian Wang, Hongchuan Jin   +12 more
semanticscholar   +1 more source

Possible Involvement of HSP90-HSF1 Multichaperone Complex in Impairment of HSP72 Induction in the Failing Heart Following Myocardial Infarction in Rats

Journal of Pharmacological Sciences, 2013
It is generally accepted that an increase in the myocardial level of heat-shock protein 72 (HSP72) protects viable cardiac tissue against myocardial infarction (MI)-induced stress.
Tetsuro Marunouchi, Masato Araki, Mao Murata, Norio Takagi, Kouichi Tanonaka   +4 more
doaj   +1 more source

HSF1: Primary Factor in Molecular Chaperone Expression and a Major Contributor to Cancer Morbidity

Cells, 2020
Heat shock factor 1 (HSF1) is the primary component for initiation of the powerful heat shock response (HSR) in eukaryotes. The HSR is an evolutionarily conserved mechanism for responding to proteotoxic stress and involves the rapid expression of heat ...
Thomas L. Prince, Benjamin J. Lang, Martin E. Guerrero-Gimenez, Juan Manuel Fernandez-Muñoz, Andrew Ackerman, Stuart K. Calderwood   +5 more
doaj   +1 more source

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis [PDF]

, 2012
Intrinsic stress response pathways are frequently mobilized within tumor cells. The mediators of these adaptive mechanisms and how they contribute to carcinogenesis remain poorly understood.
Alessi, Bollag, Chengkai Dai, Diaz, Gitler, Gutmann, Hyoungtae Kwon, Jiayuan Shi, Junxia Cao, Khaleque, Largaespada, Luke Whitesell, Roderick T. Bronson, Sandro Santagata, Stewart, Susan Lindquist, Voellmy, Whitesell, Zheng, Zijian Tang   +19 more
core   +1 more source

Cosmological Effects of Powerful AGN Outbursts in Galaxy Clusters: Insights from an XMM-Newton Observation of MS0735+7421 [PDF]

, 2006
We report on the results of an analysis of XMM-Newton observations of MS0735+7421, the galaxy cluster which hosts the most energetic AGN outburst currently known.
B. R. McNamara, Bohringer H., Cavaliere A., Churazov E., De Grandi S., Eke V. R., Kaiser N., Lacey C., M. Gitti, M. W. Wise, P. E. J. Nulsen, Ponman T. J., Tabor G., White S. D. M.   +13 more
core   +2 more sources

Heat shock factor 1 protects germ cell proliferation during early ovarian differentiation in medaka

Scientific Reports, 2019
The heat shock response is important for the viability of all living organisms. It involves the induction of heat shock proteins whose expression is mainly regulated by heat shock factor 1 (HSF1).
Fumiya Furukawa, Shinji Hamasaki, Seiji Hara, Tomoya Uchimura, Eri Shiraishi, N. Osafune, H. Takagi, T. Yazawa, Y. Kamei, T. Kitano   +9 more
semanticscholar   +1 more source