Results 51 to 60 of about 650,866 (279)

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage [PDF]

, 2009
Here we define an important role for heat shock factor 1 (HSF1) in the cellular response to genotoxic agents. We demonstrate for the first time that HSF1 can complex with nuclear p53 and that both proteins are co-operatively recruited to p53-responsive ...
Abravaya, An, Ashcroft, Banin, Bates, Boellmann, Bourdon, Brummelkamp, Bruno, Bunz, Canman, Chen, Chuikov, Craig N. Robson, Dai, Dai, David W. Meek, el-Deiry, Enari, Espinosa, Fernandes, Frances V. Fuller-Pace, Gaughan, Gomes, Green, Gu, Gu, Hardcastle, Hesta V. McNeill, Hollstein, Honda, Ian R. Logan, Jedlicka, John Lunec, Jolly, Kaeser, King, Kohn, Lees-Miller, Levine, Logan, Logan, Logan, Luft, McMillan, Meek, Meek, Min, Momand, Morimoto, Nakai, Nakano, Nylandsted, Olivier, Pirkkala, Prives, Rossi, Samuels-Lev, Shieh, Shieh, Shikama, Siliciano, Smith, Susan Cook, Tibbetts, Tovar, Vassilev, Vujanac, Vydra, Walerych, Wang, Westerheide, Xiaohong Lu, Yang, Yao, Yu, Zheng, Zhou, Zou, Zylicz   +79 more
core   +4 more sources

New inhibitor targeting human transcription factor HSF1: effects on the heat shock response and tumour cell survival. [PDF]

, 2017
© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which
Kirton, Stewart
core   +2 more sources

Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1 [PDF]

, 2020
Cancer therapeutics: Extending a drug's reach A new drug that blocks heat shock proteins (HSPs), helper proteins that are co-opted by cancer cells to promote tumor growth, shows promise for cancer treatment.
Chae, Young Chan, Hong, Jun-Hee, Hu, Sung, Kang, Byoung Heon, Kim, So Yeon, Lee, Ji-Eun, Nam, Dougu, Park, Hye-Kyung, Park, Jong Bae, Yoon, Nam Gu, Yoon, Sora   +10 more
core   +1 more source

Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. [PDF]

PLoS ONE, 2011
Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses. Under normal growth conditions HSF1 is repressed as an inactive monomer in part through post-translation modifications that include protein
Liliana Batista-Nascimento, Daniel W Neef, Phillip C C Liu, Claudina Rodrigues-Pousada, Dennis J Thiele   +4 more
doaj   +1 more source

TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid [PDF]

, 2012
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment ...
Abdul HM, Alice L. Yu, Aslan M, Bilska A, Buniatian GH, Cabell L, Carini M, Chong MS, Esposito G, Fuchshofer R, Fuchshofer R, Fukuchi T, Furuyoshi N, Gaitanaki C, Hatten ME, He S, Hernandez MR, Hernandez MR, Hernandez MR, Hernandez MR, Hodges NJ, Ihnat MA, Izzotti A, Jerome Moriniere, Kobayashi S, Kumar DM, Lambert W, Louhelainen M, Lutjen-Drecoll E, Malone PE, Markesbery WR, Meldrum B, Mozaffarieh M, Neufeld AH, Neumann C, Ohia SE, Oksala NK, Oksala NK, Pena JD, Picht G, Proell V, Ridet JL, Sacca SC, Salinthone S, Samali A, Sharp FR, Shin JH, Smith AR, Sturrock A, Tezel G, Tezel G, Tripathi RC, Ulrich Welge-Lussen, Valencia A, Veach J, Várkonyi T, Yang KL, Yang P, Yu AL, Yu AL, Zimmer DB   +60 more
core   +1 more source

Activity-Regulated Cytoskeleton-Associated Protein (Arc/Arg3.1) is Transiently Expressed after Heat Shock Stress and Suppresses Heat Shock Factor 1

Scientific Reports, 2019
Heat shock proteins are induced by activation of heat shock factor 1 (HSF1) in response to heat shock and protect against heat stress. However, the molecular mechanisms underlying the downstream signal of heat shock have not been fully elucidated.
A. Park, Yeon Seung Park, Dami So, In-Kang Song, Jung-Eun Choi, H. Kim, Hee‐Jung Kim, Kong-Joo Lee   +7 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Physiological responses to a short-term, environmentally realistic, acute heat stress in Atlantic salmon, Salmo salar

FACETS, 2017
Atlantic salmon populations are declining, and warming river temperatures in the summer months are thought to be a significant contributing factor. We describe the time course of cellular and metabolic responses to an ecologically relevant short-term ...
Melanie J. Gallant, Sacha LeBlanc, Tyson J. MacCormack, Suzanne Currie   +3 more
doaj   +1 more source

A DNA sequence directed mutual transcription regulation of HSF1 and NFIX involves novel heat sensitive protein interactions. [PDF]

PLoS ONE, 2009
BACKGROUND: Though the Nuclear factor 1 family member NFIX has been strongly implicated in PDGFB-induced glioblastoma, its molecular mechanisms of action remain unknown.
Umashankar Singh, Erik Bongcam-Rudloff, Bengt Westermark   +2 more
doaj   +1 more source