Results 91 to 100 of about 7,838,486 (292)

Dynamic Loading Regulates Meniscus‐Like Matrix Production in Human Mesenchymal Stromal Cell‐Seeded PET Scaffolds

Advanced Healthcare Materials, EarlyView.
Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira, Luisa de Roy, Anna‐Lotta Feldmeier, Mubashir Ahmad, Sofia Pilão, Maria Ahrens, Anita Ignatius, Carsten Linti, Andreas Martin Seitz   +8 more
wiley   +1 more source

Distinctive immunohistochemical profiles of small heat shock proteins (Heat shock protein 27 and αB‐crystallin) in human brain tumors [PDF]

Cancer, 1996
Recent studies have described alpha B-crystallin as a member of the small heat shock protein (HSP) family, and the expressions of alpha-crystallin-related small heat shock proteins, namely HSP27 and alpha B-crystallin, in the brain appear to be regulated in a similar way by various stress conditions.A comparative immunohistochemical analysis was ...
T, Hitotsumatsu, T, Iwaki, M, Fukui, J, Tateishi   +3 more
openaire   +2 more sources

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
Stuart, Rosemary A., Neupert, Walter, Cyr, Douglas M.   +2 more
core   +1 more source

Self‐Healing Hydrogel‐Enabled Modular Assembly of Bilayered Skin Construct for Hair Follicle Regeneration

Advanced Healthcare Materials, EarlyView.
Self‐healing assembly of two cell‐laden hydrogel layers creates a biomimetic skin construct that restores both dermal and epidermal functions, resulting in accelerated wound healing and enhanced hair follicle regeneration in a full‐thickness skin wound model. ABSTRACT Alopecia remains a pervasive clinical challenge, largely owing to the limited ability
JaeWook Park, Su Yong Kim, MinSu Jeong, Beom Joon Kim, Shin Hyuk Kang, Won‐Gun Koh   +5 more
wiley   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source

Effects of transport stress on pathological injury and expression of main heat shock proteins in the caprine stomach

BMC Veterinary Research, 2020
Background Transportation is necessary to introduce new breeds of goats to the farm and move the adult meat goat from the farm to the slaughterhouse. However, these actions may give rise to transport stress.
Wei Hu, Tian Ye, Yanzhen Yang, Ben Liu, Wenya Zheng   +4 more
doaj   +1 more source

Arabidopsis HEAT SHOCK TRANSCRIPTION FACTORA1b overexpression enhances water productivity, resistance to drought, and infection [PDF]

, 2013
Heat-stressed crops suffer dehydration, depressed growth, and a consequent decline in water productivity, which is the yield of harvestable product as a function of lifetime water consumption and is a trait associated with plant growth and development ...
Schöffl, F., Hickman, Richard D. G., Sparrow, Penelope A.C., Albihlal, Waleed S, Lawson, Tracy, Sparrow, P.A.C., Persad, R., Beynon, Jim L., Sparrow, Penelope A. C., Persad, Ramona, Bowden, L., Ott, S., Beynon, Jim L, Hickman, Richard, Bechtold, Ulrike, Beynon, Jim, Baker, Neil R, Mullineaux, Philip M., Schoeffl, Friedrich, Bechtold, U., Schoffl, Friedrich, Baker, N. R., Morison, J.L., Richard, F., Bowden, Laura, Mullineaux, Philip M, Mullineaux, P.M., Martin, Cathie, Albihlal, W.S., Fryer, Michael J., Buchanan-Wollaston, V., Fryer, Michael J, Morison, James I.L., Buchanan-Wollaston, Vicky, Sparrow, Penelope AC, Baker, N.R., Baker, Neil R., Hickman, R., Martin, C., Albihlal, Waleed S., Morison, James I. L., Richard, François, Ott, Sascha, Morison, James IL, Fryer, M.J., Lawson, T., Beynon, J.L.   +46 more
core   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Overexpression of human HSP27 protects sensory neurons from diabetes

Neurobiology of Disease, 2012
Summary: Objectives: To evaluate whether augmenting neuronal protective mechanisms might slow or arrest experimental diabetic peripheral neuropathy (DPN). DPN is one of the most common neurodegenerative disorders and is rising in prevalence.
L. Korngut, C.H.E. Ma, J.A. Martinez, C.C. Toth, G.F. Guo, V. Singh, C.J. Woolf, D.W. Zochodne   +7 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source