Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. [PDF]
PLoS ONE, 2012 Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate.
Benjamin Gibert +10 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Heat shock protein 27 is spatially distributed in the human placenta and decreased during labor. [PDF]
PLoS ONE, 2013 Placental oxidative stress is a feature of human labor. Heat shock proteins (HSPs) play a key role in cellular stress. We hypothesized that placental expression of the small HSP 27 would be altered during labor and expression would vary in different ...
Akrem Abdulsid +2 more
doaj +1 more source
Cloning and characterisation of heat shock and wound-induced genes in pea (pisum sativum L.) [PDF]
, 1997 Plant productivity in many regions of the world is limited primarily as a result of environmental stresses. High temperature and wounding caused by pest and pathogen infection are among the main factors accounting for unpredictable and often severe yield
Dhankher, Om Parkash
core
Heat shock proteins and the cellular response to osmotic stress [PDF]
, 2000 In antidiuresis, the intrarenal distribution of HSP25/27, alpha beta -crystallin, HSP72, OSP94 and HSP110 corresponds to the osmotic gradient between cortex and papilla: low amounts in the cortex and high values in the inner medulla and papilla.
Lugmayr, Karin +3 more
core +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Acute Heat Stress and Reduced Nutrient Intake Alter Intestinal Proteomic Profile and Gene Expression in Pigs. [PDF]
PLoS ONE, 2015 Heat stress and reduced feed intake negatively affect intestinal integrity and barrier function. Our objective was to compare ileum protein profiles of pigs subjected to 12 hours of HS, thermal neutral ad libitum feed intake, or pair-fed to heat stress ...
Sarah C Pearce +4 more
doaj +1 more source
Heat‐shock protein 27 is a major methylglyoxal‐modified protein in endothelial cells [PDF]
FEBS Letters, 2006 In endothelial cells cultured under high glucose conditions, methylglyoxal is the major intracellular precursor in the formation of advanced glycation endproducts. We found that endothelial cells incubated with 30 mM d‐glucose produced approximately 2‐fold higher levels of methylglyoxal but not 3‐deoxyglucosone and glyoxal, as compared to 5 mM d ...
Schalkwijk, Casper G. +5 more
openaire +2 more sources
HSPB1 (Heat-Shock 27 kDa Protein 1) [PDF]
, 2010 Review on HSPB1 (Heat-Shock 27 kDa Protein 1), with data on DNA, on the protein encoded, and where the gene is ...
E Matuszewska +5 more
core +1 more source