Results 1 to 10 of about 310,859 (196)

Heat shock protein 90 inhibition in the endothelium [PDF]

Frontiers in Medicine, 2023
Nektarios Barabutis
doaj   +4 more sources

Activity of the heat shock protein 90 inhibitor ganetespib in melanoma. [PDF]

PLoS ONE, 2013
Heat shock protein 90 (HSP90) is involved in the regulation of diverse biological processes such as cell signaling, proliferation and survival, and has been recently recognized as a potential target for cancer therapy.
Xinqi Wu, Melina E Marmarelis, F Stephen Hodi   +2 more
doaj   +13 more sources

Heat shock protein 90 in neurodegenerative diseases [PDF]

Molecular Neurodegeneration, 2010
Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation. In addition to its well-characterized functions in malignancy, recent evidence from several laboratories suggests a role for Hsp90 in maintaining the functional ...
Rodina Anna, Taldone Tony, Sun Weilin, Luo Wenjie, Chiosis Gabriela   +4 more
doaj   +3 more sources

Heat Shock Protein 90 regulates encystation in Entamoeba [PDF]

Frontiers in Microbiology, 2015
Enteric protozoan Entamoeba histolytica is a major cause of debilitating diarrheal infection worldwide with high morbidity and mortality. Even though the clinical burden of this parasite is very high, this infection is categorized as a neglected disease.
Meetali eSingh, Shalini eSharma, Alok eBhattacharya, Utpal eTatu   +3 more
doaj   +4 more sources

The development of cancers research based on mitochondrial heat shock protein 90 [PDF]

Frontiers in Oncology, 2023
Mitochondrial heat shock protein 90 (mtHsp90), including Tumor necrosis factor receptor-associated protein 1 (TRAP1) and Hsp90 translocated from cytoplasm, modulating cellular metabolism and signaling pathways by altering the conformation, activity, and ...
Yuchu Xiang, Xudong Liu, Qi Sun, Kuo Liao, Xiaohan Liu, Zihui Zhao, Lishuang Feng, Yan Liu, Bo Wang, Bo Wang   +9 more
doaj   +2 more sources

Heat shock protein 90 targeting therapy [PDF]

, 2015
Heat shock protein 90 (Hsp90) is an ATP-dependent molecular chaperone that plays a role in stabilizing and activating more than 200 client proteins. It is required for the stability and function of numerous oncogenic signaling proteins that determine the
Kihara, Kazunori, Koga, Fumitaka, Tatokoro, Manabu, Yoshida, Soichiro   +3 more
core   +3 more sources

Spotlight on the microbes that produce heat shock protein 90-targeting antibiotics [PDF]

Open Biology, 2012
Heat shock protein 90 (Hsp90) is a promising cancer drug target as a molecular chaperone critical for stabilization and activation of several of the oncoproteins that drive cancer progression.
Peter W. Piper, Stefan H. Millson
doaj   +4 more sources

Heat Shock Protein 90 (Hsp90) Expression and Breast Cancer [PDF]

Pharmaceuticals, 2012
Hsp90 is an abundant protein in mammalian cells. It forms several discrete complexes, each containing distinct groups of co-chaperones that assist protein folding and refolding during stress, protein transport and degradation. It interacts with a variety
Christos A. Papadimitriou, Konstantinos Koutsoukos, Evangelos Bournakis, Flora Zagouri   +3 more
doaj   +4 more sources

Heat shock protein 90 is a chaperone regulator of HIV-1 latency. [PDF]

PLoS Pathogens
An estimated 32 million people live with HIV-1 globally. Combined antiretroviral therapy suppresses viral replication but therapy interruption results in viral rebound from a latent reservoir mainly found in memory CD4+ T cells.
Somaya Noorsaeed, Nawal AlBurtamani, Ahmed Rokan, Ariberto Fassati   +3 more
doaj   +2 more sources

Heat Shock Protein 90 Inhibitors repurposed against Entamoeba histolytica [PDF]

Frontiers in Microbiology, 2015
Hsp90 is an essential chaperone responsible for trafficking a vast array of client proteins, which are substrates that Hsp90 regulates in eukaryotic cells under stress conditions.
Dea eShahinas, Anjan eDebnath, Christan eBenedict, James H McKerrow, Dylan R Pillai   +4 more
doaj   +3 more sources