Heat shock protein 90: biological functions, diseases, and therapeutic targets [PDF]
MedCommHeat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It collaborates
Huiyun Wei +7 more
doaj +2 more sources
Correction: Activity of the Heat Shock Protein 90 Inhibitor Ganetespib in Melanoma. [PDF]
PLoS ONE[This corrects the article DOI: 10.1371/journal.pone.0056134.].
Xinqi Wu +2 more
doaj +2 more sources
Heat shock proteins: a therapeutic target worth to consider [PDF]
Veterinary World, 2015 Heat shock proteins (HSPs) are the molecular chaperones, that are not only expressed during the normal growth process of cell cycle consecutively, but also get induced in cells during various stress conditions produced by cellular insult, environmental ...
Amita Dubey +3 more
doaj +1 more source
Heat shock protein 90 has roles in intracellular calcium homeostasis, protein tyrosine phosphorylation regulation, and progesterone-responsive sperm function in human sperm. [PDF]
PLoS ONE, 2014 Heat shock protein 90 plays critical roles in client protein maturation, signal transduction, protein folding and degradation, and morphological evolution; however, its function in human sperm is not fully understood.
Kun Li +7 more
doaj +1 more source
Differential expression of heat shock protein 90, 70, 60 in chicken muscles postmortem and its relationship with meat quality [PDF]
Asian-Australasian Journal of Animal Sciences, 2017 Objective The aim of this study was to investigate the expression of heat shock protein (HSP) 90, 70, and 60 in chicken muscles and their possible relationship with quality traits of meat. Methods The breast muscles from one hundred broiler chickens were
Muhan Zhang +7 more
doaj +1 more source
Crowding Activates Heat Shock Protein 90 [PDF]
Journal of Biological Chemistry, 2016 Hsp90 is a dimeric ATP-dependent chaperone involved in the folding, maturation, and activation of diverse target proteins. Extensive in vitro structural analysis has led to a working model of Hsp90's ATP-driven conformational cycle. An implicit assumption is that dilute experimental conditions do not significantly perturb Hsp90 structure and function ...
Jackson C, Halpin +3 more
openaire +2 more sources
Heat Shock Protein 90 in Alzheimer’s Disease [PDF]
BioMed Research International, 2014 Alzheimer’s disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation of the intracellular microtubule ...
Jiang-Rong Ou +4 more
openaire +2 more sources
Hypoglycemia Impairs the Heat Shock Protein Response: A Risk for Heat Shock in Cattle?
Frontiers in Veterinary Science, 2022 BackgroundHeat stress (HS) in cattle is a major debilitating problem, affecting health and milk yield. Physiologically, HS has been shown to lower blood glucose levels to 2.5 mmol/l (45 mg/dl) and results in upregulation of heat shock proteins (HSPs ...
Samuel A. Atkin +3 more
doaj +1 more source
Heat shock protein 90 inhibitor RGRN-305 potently attenuates skin inflammation
Frontiers in Immunology, 2023 IntroductionChronic inflammatory skin diseases may have a profound negative impact on the quality of life. Current treatment options may be inadequate, offering an unsatisfactory response or side effects.
Hakim Ben Abdallah +6 more
doaj +1 more source
Heat Shock Protein 70 and 90 Family in Prostate Cancer
Life, 2022 Prostate cancer (PCa) is the second most frequent cancer that affects aging men worldwide. However, its exact pathogenesis has not been fully elucidated. The heat shock protein (HSP) family has cell-protective properties that may promote tumor growth and
Xun Fu +4 more
doaj +1 more source