Effects of Heat Shock Protein 90 Inhibition In the Lungs
Medicine in Drug Discovery, 2020 Inhibition of Hsp90 is associated with anti-inflammatory effects. We employed human lung microvascular endothelial cells to investigate the effects of the Hsp90 inhibitors 17-AAG, AUY-922 and 17-DMAG in the unfolded protein response (UPR) and viability ...
Mohammad A. Uddin +5 more
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Extracellular Heat Shock Protein-90 (eHsp90): Everything You Need to Know
Biomolecules, 2022 “Extracellular” Heat Shock Protein-90 (Hsp90) was initially reported in the 1970s but was not formally recognized until 2008 at the 4th International Conference on The Hsp90 Chaperone Machine (Monastery Seeon, Germany).
Daniel Jay, Yongzhang Luo, Wei Li
doaj +1 more source
Down regulation effect of Rosmarinus officinalis polyphenols on cellular stress proteins in rat pheochromocytoma PC12 cells [PDF]
, 2012 Polyphenols are known to exhibit wide spectrum of benefit for brain health and to protect from several neurodegenerative diseases. The present study was sought to determine the neuroprotective effects of Rosmarinus officinalis’ polyphenols (luteolin ...
Abdrabbah Manef Ben +5 more
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Heat Shock Factor 1 is a Substrate for p38 Mitogen-Activated Protein Kinases [PDF]
, 2016 Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation at S326 is a hallmark for HSF1 activation, but the identity of the kinase(s) phosphorylating this site has remained elusive. We show here that the dietary agent
Benjamin, Ivor J +13 more
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BIIB021: A novel inhibitor to heat shock protein 90–addicted oncology
Tumor Biology, 2017 Heat shock protein 90 is induced in response to the cell stress. Its overexpression has been reported in many cancers with poor prognosis. It acts as a chaperone to the client proteins, especially the activated oncoproteins in malignancies to protect ...
Liang Yan +4 more
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DNA vaccine encoding heat shock protein 90 protects from murine lupus
Arthritis Research & Therapy, 2020 Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies to multiple self-antigens, including heat shock proteins (HSP). Because of the increased expression of HSP90 and abnormal immune
Aijing Liu +6 more
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Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma. [PDF]
PLoS ONE, 2013 Metastatic pheochromocytoma represents one of the major clinical challenges in the field of neuroendocrine oncology. Recent molecular characterization of pheochromocytoma suggests new treatment options with targeted therapies.
Alessio Giubellino +9 more
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Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]
, 2016 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching +7 more
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Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]
, 2014 The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher +3 more
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Heat shock protein 90 inhibition: rationale and clinical potential
Therapeutic Advances in Medical Oncology, 2012 Heat shock protein 90 (HSP90) is a molecular chaperone protein essential for cellular survival. Functionally, HSPs promote proper protein folding, prevent misfolding, and restore three-dimensional protein structure which is critical following toxic ...
Robert B. Den, Bo Lu
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