Results 41 to 50 of about 310,958 (294)

Early redox activities modulate Xenopus tail regeneration. [PDF]

, 2018
Redox state sustained by reactive oxygen species (ROS) is crucial for regeneration; however, the interplay between oxygen (O2), ROS and hypoxia-inducible factors (HIF) remains elusive.
Ferreira, Fernando, Luxardi, Guillaume, Raghunathan, VijayKrishna, Zhao, Min, Zhu, Kan   +4 more
core   +2 more sources

Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]

, 2009
The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele, De Martino, Luisa, Di Stefano, Carla, Fiorito, Filomena, Indelicato, Manuela, Marfe, Gabriella, Pucci, Bruna, Russo, Matteo A., Tafani, Marco   +8 more
core   +1 more source

Effect of EPA on Hsp90 and GRα protein expression in multiple myeloma drug-resistant cells

BMC Cancer, 2021
Background Approximately 20% of MM patients harbor glucocorticoid (GC) resistance and are not responsive to therapeutic effect. Chaperoneheat-shock proteins Hsp90 is needed for ligand docking, The imbalance of Hsp90/GRα (glucocorticoid receptor α) may be
Shenghao Wu, Yuemiao Chen, Xueshuang Wang, Shanshan Weng, Wenjin Zhou, Zhen Liu   +5 more
doaj   +1 more source

Trans-spliced heat shock protein 90 modulates encystation in Giardia lamblia.

PLoS Neglected Tropical Diseases, 2014
BackgroundHsp90 from Giardia lamblia is expressed by splicing of two independently transcribed RNA molecules, coded by genes named HspN and HspC located 777 kb apart.
Rishi Kumar Nageshan, Nainita Roy, Shatakshi Ranade, Utpal Tatu   +3 more
doaj   +1 more source

Short-term heat acclimation is effective and may be enhanced rather than impaired by dehydration [PDF]

, 2014
Most heat acclimation data are from regimes longer than 1 week, and acclimation advice is to prevent dehydration. Objectives: We hypothesized that (i) short-term (5-day) heat acclimation would substantially improve physiological strain and exercise ...
Armstrong, Armstrong, Ashenden, Bergeron, Borg, Brandenberger, Brandenberger, Brengelmann, Buono, Buono, Burge, Casa, Casa, Cheung, Convertino, Convertino, Costill, Cotter, Creasy, Dill, Engell, Epstein, Fellman, Fleming, Fortney, Francesconi, Gabai, Gagge, Garrett, Garrett, Garrett, Gisolfi, Gonzalez-Alonso, Gore, Goulet, Graichen, Greenleaf, Harrison, Harrison, Hopkins, Hopper, Horowitz, Horowitz, Hurwitz, Joyner, Judelson, Kay, Kee-Bum, Kenefick, Lorenzo, Maresh, Marshall, McClung, McConell, Merry, Morris, Moseley, Nadel, Nagashima, Nielsen, Njemini, Noakes, Nose, Oehler, Okazaki, Okazaki, Patterson, Patterson, Patterson, Racinais, Ramanathan, Sawka, Sawka, Sawka, Sawka, Schwimmer, Scoon, Senay, Shido, Shvartz, Strydom, Tetievsky, Turk, Wall, Weller, Witney, Wyndham   +86 more
core   +1 more source

CUL-6/cullin ubiquitin ligase-mediated degradation of HSP-90 by intestinal lysosomes promotes thermotolerance

Cell Reports
Summary: Heat shock can be a lethal stressor. Previously, we described a CUL-6/cullin-ring ubiquitin ligase complex in the nematode Caenorhabditis elegans that is induced by intracellular intestinal infection and proteotoxic stress and that promotes ...
Mario Bardan Sarmiento, Spencer S. Gang, Patricija van Oosten-Hawle, Emily R. Troemel   +3 more
doaj   +1 more source

Temperature stress response of heat shock protein 90 (Hsp90) in the clam Paphia undulata

Aquaculture and Fisheries, 2018
The Heat shock proteins (HSPs) are a group of molecular chaperones that play a crucial role in cell response to various stresses. A full-length cDNA of the heat shock protein 90 (PuHsp90) was cloned and sequenced from the clam Paphia undulata ...
Xiangyang Lin, Xiangwei Wu, Xiande Liu
doaj   +1 more source

Immunohistochemical expression of interlukin10 (IL10) and heat shock protein-90 (HSP-90) in prostatic carcinoma

Indian Journal of Pathology and Microbiology, 2020
Background: Specific cytokines are related to pathologically changed prostate, propose that the balance in cytokine differs in normal and pathological prostate.
Wasan Abdul-ilah Bakir, Hiba Ahmed Gaidan, Methaq Mueen Al-kaabi   +2 more
doaj   +1 more source

HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. [PDF]

, 2019
Small-molecule inhibitors for the 90-kDa heat shock protein (HSP90) have been extensively exploited in preclinical studies for the therapeutic interventions of human diseases accompanied with proteotoxic stress.
Chen, Xuemei, Dai, Xiaoxia, Li, Lin, Miao, Weili, Wang, Yinsheng, Zhao, Yonghui   +5 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source