LPS-induced delayed preconditioning is mediated by Hsp90 and involves the heat shock response in mouse kidney. [PDF]
PLoS ONE, 2014 We and others demonstrated previously that preconditioning with endotoxin (LPS) protected from a subsequent lethal LPS challenge or from renal ischemia-reperfusion injury (IRI).
Tamás Kaucsár +10 more
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The Heat Shock Response in the Western Honey Bee (Apis mellifera) is Antiviral
Viruses, 2020 Honey bees (Apis mellifera) are an agriculturally important pollinator species that live in easily managed social groups (i.e., colonies). Unfortunately, annual losses of honey bee colonies in many parts of the world have reached unsustainable levels ...
Alexander J. McMenamin +2 more
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Heat Shock Response and Heat Shock Proteins: Current Understanding and Future Opportunities in Human Diseases. [PDF]
Int J Mol SciThe heat shock response is an evolutionarily conserved mechanism that protects cells or organisms from the harmful effects of various stressors such as heat, chemicals toxins, UV radiation, and oxidizing agents.
Singh MK +7 more
europepmc +2 more sources
The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. [PDF]
PLoS ONE, 2013 The heat shock response, the cellular response to protein damaging stress, is critical in maintaining proteostasis. The heat shock response is regulated by the transcription factor HSF1, which is activated upon heat shock and other stresses to induce the
Rachel Raynes +5 more
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The heat shock response in neurons and astroglia and its role in neurodegenerative diseases
Molecular Neurodegeneration, 2017 Protein inclusions are a predominant molecular pathology found in numerous neurodegenerative diseases, including amyotrophic lateral sclerosis and Huntington’s disease.
Rebecca San Gil +3 more
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Transcriptional and translational dynamics underlying heat shock response in the thermophilic crenarchaeon Sulfolobus acidocaldarius [PDF]
mBio, 2023 High-temperature stress is critical for all organisms and induces a profound cellular response. For Crenarchaeota, little information is available on how heat shock affects cellular processes and on how this response is regulated.
Rani Baes +10 more
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Heat shock response and homeostatic plasticity
Frontiers in Cellular Neuroscience, 2015 Heat shock response and homeostatic plasticity are mechanisms that afford functional stability to cells in the face of stress. Each mechanism has been investigated independently, but the link between the two has not been extensively explored.
SHANKER eKARUNANITHI, Ian Ross Brown
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Barcoding heat shock proteins to human diseases: looking beyond the heat shock response
Disease Models & Mechanisms, 2014 There are numerous human diseases that are associated with protein misfolding and the formation of toxic protein aggregates. Activating the heat shock response (HSR) – and thus generally restoring the disturbed protein homeostasis associated with such ...
Vaishali Kakkar +4 more
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Unveiling the novel regulatory roles of RpoD-family sigma factors in Salmonella Typhimurium heat shock response through systems biology approaches. [PDF]
PLoS GeneticsThree RpoD-family sigma factors, RpoD, RpoS, and RpoH, play critical roles in transcriptional regulation in Salmonella enterica serovar Typhimurium under heat shock conditions.
Joon Young Park +5 more
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Impaired heat shock response in cells expressing full-length polyglutamine-expanded huntingtin. [PDF]
PLoS ONE, 2012 The molecular mechanisms by which polyglutamine (polyQ)-expanded huntingtin (Htt) causes neurodegeneration in Huntington's disease (HD) remain unclear. The malfunction of cellular proteostasis has been suggested as central in HD pathogenesis and also as ...
Sidhartha M Chafekar, Martin L Duennwald
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