Results 51 to 60 of about 870,730 (334)

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Brain : a journal of neurology, 2016
Insoluble TDP-43 inclusions are the pathological hallmark of ALS and tau-negative frontotemporal lobar degeneration. Chen et al. show that the heat shock response (HSR), which regulates chaperone expression, is compromised in an ALS mouse model and in ...
Han-Jou Chen, Jacqueline C Mitchell, S. Novoselov, Jack W. Miller, A. Nishimura, Emma L. Scotter, C. Vance, M. Cheetham, C. Shaw   +8 more
semanticscholar   +1 more source

Heat shock induces expression of OSTC/DC2, a novel subunit of oligosaccharyltransferase, in vitro and in vivo

Kaohsiung Journal of Medical Sciences, 2014
Mammalian oligosaccharyltransferase complex subunit OSTC/DC2 protein has recently been shown to be a new subunit of the oligosaccharyltransferase; however, its physiological role is still unclear.
Chien-Ming Chen, Chao-Neng Tseng, Jonathan J. Cho, Ya-Zhe Lee, Chiu-Li Kao, Yuan-Bin Cheng, Yi-Ren Hong, Chung-Lung Cho   +7 more
doaj   +1 more source

Polycomb response elements reduce leaky expression of Cas9 under temperature-inducible Hsp70Bb promoter in Drosophila melanogaster

G3: Genes, Genomes, Genetics, 2023
Heat-shock-inducible expression of genes through the use of heat-inducible promoters is commonly used in research despite leaky expression of downstream genes of interest without targeted induction (i.e. heat shock).
Natalie Warsinger-Pepe, Carly Chang, Connor R Desroberts, Omar S Akbari   +3 more
doaj   +1 more source

E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response

Genes & Development, 2016
In this study, Li et al. characterize the genomic distribution and transcriptional activity of C. elegans HSF-1 during larval development and show that the developmental HSF-1 transcriptional program is distinct from the heat-shock response.
Jian Li, L. Chauve, Grace Phelps, Renee M. Brielmann, R. Morimoto   +4 more
semanticscholar   +1 more source

Correction: Heat shock response in archaea [PDF]

Emerging Topics in Life Sciences, 2018
Emerging Topics in Life Sciences (2018) https://doi.org/10.1042/ETLS20180024 In the Ahead-of-Print version published on 22 November 2018, the titles/captions for [Figures 1][1] and [3][2] were accompanied by the wrong artwork.
Liesbeth, Lemmens, Rani, Baes, Eveline, Peeters   +2 more
openaire   +2 more sources

Transcriptional profiling of Arabidopsis heat shock proteins and transcription factors reveals extensive overlap between heat and non-heat stress response pathways

BMC Genomics, 2007
Background The heat shock response of Arabidopsis thaliana is dependent upon a complex regulatory network involving twenty-one known transcription factors and four heat shock protein families. It is known that heat shock proteins (Hsps) and transcription
Weber Andreas P, Huebner Marianne, Swindell William R   +2 more
doaj   +1 more source

Caenorhabditis elegans AF4/FMR2 Family Homolog affl-2 Regulates Heat-Shock-Induced Gene Expression [PDF]

, 2020
To mitigate the deleterious effects of temperature increases on cellular organization and proteotoxicity, organisms have developed mechanisms to respond to heat stress.
Bateman, Alex, Quintero-Cadena, Porfirio, Sternberg, Paul W., Walton, Sophie J., Wang, Han   +4 more
core   +1 more source

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators.

Genes & Development, 1998
Our cells and tissues are challenged constantly by exposure to extreme conditions that cause acute and chronic stress. Consequently, survival has necessitated the evolution of stress response networks to detect, monitor, and respond to environmental ...
R. Morimoto
semanticscholar   +1 more source

Heat Shock Response, Heat Shock Transcription Factor and Cell Aging

Neurosignals, 1996
A characteristic feature of aging is a progressive impairment in the ability to adapt to environmental challenges. The purpose of this article is to review the evidence of an attenuated response to heat and physiological stresses in a number of mammalian aging model systems, including the human diploid fibroblasts in culture, whole animals and animal ...
Y K, Lee, D, Manalo, A Y, Liu
openaire   +2 more sources

Metallothioneins are required for formation of cross-adaptation response to neurobehavioral toxicity from lead and mercury exposure in nematodes. [PDF]

PLoS ONE, 2010
Metallothioneins (MTs) are small, cysteine-rich polypeptides, but the role of MTs in inducing the formation of adaptive response is still largely unknown.
Boping Ye, Qi Rui, Qiuli Wu, Dayong Wang
doaj   +1 more source