Results 101 to 110 of about 47,318 (263)

Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment

Advanced Science, EarlyView.
This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo, Yijuan Wang, Dengwang Chen, Yinghan Zhang, Yi Shuai, Hualiang Yao, Tao Jiang, Hang Jiang, Ming Zhong, Xiangeng Wang, Ziwei Wang, Chenchen Xu, Ajay Goel, Hoi Tang MA, Feng Gao, Xin Wang   +15 more
wiley   +1 more source

HUMAN HEALTH RISK ASSESSMENT: A CASE STUDY OF HEAVY METAL CONTAMINATION OF GARDEN SOILS IN SZEGED [PDF]

Acta Geographica Debrecina. Landscape & Environment Series, 2009
The soils of the big cities, owing to the various anthropogenic activities, can be contaminated by heavy metals. The surroundings of the roads with heavy traffic as significant metal emitter source can be contaminated by heavy metals.
ANDREA FARSANG, IRÉN PUSKÁS, ZSUZSANNA SZOLNOKI   +2 more
doaj  

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, EarlyView.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

A LIFO queue in heavy traffic

The Annals of Applied Probability, 2001
The author analyzes the heavy-traffic behaviour of an M/G/1 last-in-first-out preemptive resume queue using measure-valued processes developed by \textit{J.-F. Le Gall} and \textit{Y. Le Jan} [Ann. Probab. 26, No.~4, 1407-1432 (1998; Zbl 0945.60090)]. This approach captures all the relevant information about evolution of the queue.
openaire   +3 more sources

Trafficking Deficiency of TMEM175 Variants in Parkinson's Disease Pathogenesis and the Prospects of Precision Medicine

Advanced Science, EarlyView.
This study identifies that the PD‐associated TMEM175‐L156P variant disrupts lysosomal ion channel trafficking by causing aberrant endoplasmic reticulum retention. A “chaperone–agonist” bifunctional small molecule restores TMEM175‐L156P lysosomal localization and channel function, thereby alleviating PD‐relevant cellular phenotypes and highlighting a ...
Ting Luo, Yu He, Shuyao Li, Haoyu Guan, Ruili Cui, Yu Shi, Zhongwen Jiang, Siyu Wang, Xuan Li, Jiyuan Li, Mei Hu, Yupeng Zhou, Beisha Tang, Yanyan Zhang, Zhaobing Gao, Yu Zhou, Zhenhua Liu, Ping Li   +17 more
wiley   +1 more source

Construction Material for Tribo-Fatigue Systems: Fatigue Resistance and Structure

Механика машин, механизмов и материалов, 2018
A brief overview of the practical use of the new construction material of MONICA is given. An experimental study was performed for the first time on the analysis of the influence of the microstructural state on fatigue resistance.
Leonid A. Sosnovskiy, Alexander A. Novikov, Sergey S. Sherbakov, Victor V. Commissarov, Sergey A. Tyurin, Pavel S. Drobyshevskiy   +5 more
doaj  

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

Assessing health risk reduction from road traffic noise: The impact of vehicle composition and traffic speed in the transition to electric vehicles – A prediction in Sapporo City, Japan

Hygiene and Environmental Health Advances
Environmental noise poses a risk to public health. Recent societal shifts aimed at creating a low-carbon society are expected to change the acoustic landscape, such as the transition from internal combustion engine vehicles (ICEVs) to electric vehicles ...
Farah Elida Selamat, Junta Tagusari
doaj   +1 more source

A Single‐Amino‐Acid Ligand for LAT1: A Minimalist and Modular Platform for Lysosome‐Targeted Degradation of Membrane Proteins

Advanced Science, EarlyView.
LA‐LYTAC repurposes the cancer‐enriched amino acid transporter LAT1 as a lysosomal trafficking receptor for targeted membrane‐protein degradation. A single phenylalanine‐derived ligand, modularly linked to antibodies or small‐molecule binders, recruits PD‐L1, EGFR, or integrins to LAT1, triggering transporter‐mediated internalization, lysosomal ...
Liquan Zhu, Ke Liu, Haotian Liu, Chaoqi He, Xiaozhen Liu, Xin Zeng, Misha Mao, Yuxiao Mu, Ying Li, Qinghui Zheng, Hongchao Tang, Da Qian, Xuli Meng   +12 more
wiley   +1 more source

On the practical utility of a continuum traffic flow model on curvy highways in adverse weather conditions

Transportation Research Interdisciplinary Perspectives
The macroscopic continuum traffic flow models are being investigated to predict and ameliorate traffic more efficiently. These models are beneficial implementation tools to comprehend and complement the shortfalls in traffic evolution.
Waheed Imran, Zawar H. Khan, Daud Khan, Usman Ghani, Tahseen Bashir   +4 more
doaj   +1 more source