Results 81 to 90 of about 65,792 (310)
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
An investigation of road traffic noise on main roads in Greater London
, 1972 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Measurements of road traffic noise were made at 46 locations on Single-carriageway hilly main roads, subjected to speed limits, in the Greater London area ...
Blitz, Jack
core
Laws of Little in an open queueing network
Nonlinear Analysis, 2012 The object of this research in the queueing theory is theorems about the functional strong laws of large numbers (FSLLN) under the conditions of heavy traffic in an open queueing network (OQN).
Saulius Minkevičius, Stasys Steišūnas
doaj
Advanced Science, EarlyView.Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley +1 more source
Experimental determination of dynamic allowance for traffic loading in bridges
, 2012 Transportation Research Board 89th Annual Meeting, Washington DC, 2010-1-10 to 2010-1-14Bridge codes adopt values for dynamic allowance in traffic load models that are necessarily conservative to cover for an entire range of bridges with different ...
O\u27Brien, Eugene J. +4 more
core
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Nearly periodic behavior in the overloaded G/D/s+GI queue
Stochastic Systems, 2011 Under general conditions, the number of customers in a GI/D/s+GI many-server queue at time t converges to a unique stationary distribution as t → ∞. However, simulations show that the sample paths routinely exhibit nearly periodic behavior over long time
Ward Whitt, Yunan Liu
doaj
A Multiclass Hybrid Production Center in Heavy Traffic [PDF]
Operations Research, 1998 This paper presents an analysis of a single-stage hybrid production system that makes multiple types of products, some of which are made to-order while others are made to-stock. The analysis begins with a formal heavy traffic limit theorem of the production system, which is modeled as a mixed queueing network.
openaire +2 more sources
Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
The soil structural cost of traffic from heavy machinery in vertisols
, 2019 The agricultural industry has a strong and continuing trend for the incorporation of heavy machinery into the farming system, in order to create operational efficiencies. It is therefore important to understand the soil structural cost of such machinery,
Woodhouse, N. P. +6 more
core +1 more source