Results 101 to 110 of about 161,537 (288)

Wireless Bioelectronic Modulation of Membrane Potential in Glioblastoma Using Carbon Nanotube Porins

Advanced Science, EarlyView.
A schematic illustrating glioblastoma cell membrane modulation using carbon nanotube porins (CNTPs) and an applied voltage. CNTPs enable ion flux leading to changes in membrane potential. This figure summarizes the concept of bioelectronic control of cell membrane voltage.
Fleur Groualle, David Onion, Julie A. Watts, Graham A. Rance, Aleksandr Noy, Beth Coyle, Frankie J. Rawson   +6 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphe neurones and cranial motoneurones [PDF]

, 2005
In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol ...
Diamond, B, Frohnhoefer, HG, Gardiner, RM, Geisler, R, Heisenberg, CP, Houart, C, Lele, Z, Mangoli, M, Mercurio, S, Neumann, CJ, Norton, WH, Pogoda, HM, Rastegar, S, Rauch, GJ, Rees, M, Russell, C, Schilling, TF, Stickney, HL, Strahle, U, Talbot, WS, Teraoka, H, Wilson, SW   +21 more
core  

Mechanical Stimuli‐Induced Manipulation of Malignant Behavior in Bioprinted Cancer Microtissues via PI3K/NF‐κB Activation

Advanced Science, EarlyView.
A mechanically tunable ECM platform is created by integrating dECM–alginate matrices with in‐bath tumor printing. The mechanically tunable ECM environment drives tumors to acquire hypoxia, mechanotransduction signaling, metastatic traits, and drug‐resistant phenotypes that collectively promote malignant transformation.
Seok‐Hyeon Lee, Jeongho Lee, Min‐Seo Choi, Minjun Ahn, Sik Yoon, Dongjun Lee, Sae‐Ock Oh, Won‐Woo Cho, Byoung Soo Kim   +8 more
wiley   +1 more source

Demagnetization Borne Microscale Skyrmions

, 2012
Magnetic systems are an exciting realm of study that is being explored on smaller and smaller scales. One extremely interesting magnetic state that has gained momentum in recent years is the skyrmionic state.
A. Hubert, A. K. Gangopadhyay, E. Fradkin, M. Donahue, Patrick Johnson, Ramki Kalyanaraman, W. F. Brown, Jr., Zohar Nussinov   +7 more
core   +1 more source

ADAMTS9‐AS2 Disrupts Docetaxel‐Resistance in Castration‐Resistant Prostate Cancer via Stemness Suppression and Ferroptosis Induction

Advanced Science, EarlyView.
This study uncovered a dual‐track mechanism by which ADAMTS9‐AS2 overcame chemoresistance in CRPC: suppressing cancer stemness through the FOXF2/TGF‐β2 pathway, and triggering ferroptosis via competitive SLC7A11 sequestration. Polymeric materials co‐targeting these vulnerabilities further boost docetaxel sensitivity, highlighting a compelling strategy ...
Ji Liu, Yan Gao, Yadong Guo, Junfeng Zhang, Wentao Zhang, Zhuoran Gu, Haotian Chen, Chengqi Jin, Peng Luo, Shiyu Mao, Yajuan Hao, Shuo Shi, Xudong Yao   +12 more
wiley   +1 more source

Hedgehog signaling [PDF]

Journal of Cell Science, 2007
Markku, Varjosalo, Jussi, Taipale
openaire   +2 more sources

Crater Observing Bioinspired Rolling Articulator (COBRA)

Advanced Intelligent Systems, EarlyView.
Crater Observing Bio‐inspired Rolling Articulator (COBRA) is a modular, snake‐inspired robot that addresses the mobility challenges of extraterrestrial exploration sites such as Shackleton Crater. Incorporating snake‐like gaits and tumbling locomotion, COBRA navigates both uneven surfaces and steep crater walls.
Adarsh Salagame, Henry Noyes, Eric Sihite, Arash Kalantari, Alireza Ramezani   +4 more
wiley   +1 more source

Genotypes and Phenotypes of Patients With TSPEAR‐Related Disorder: Evidence of a Predominant Dental Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT TSPEAR (chr. 21q22.3) encodes a protein involved in tooth development and is predominantly expressed in the enamel knot. Biallelic loss of function variants in TSPEAR cause ectodermal dysplasia, tooth agenesis and sensorineural hearing loss. However, the role of TSPEAR in auditory processes is unclear.
Debora Vergani, Lucia Tiberi, Annarita Giliberti, Elia Dirupo, Laila Zaroili, Francesco Brancati, Michela Brena, Stefano Caraffi, Chiara De Luca, Livia Garavelli, Anna Virginia Gulino, Milena Mariani, Marzia Pollazzon, Angelo Selicorni, Samuela Landini, Ilaria Sani, Rosangela Artuso, Angela Peron   +17 more
wiley   +1 more source

Identification of Novel GANT61 Analogs with Activity in Hedgehog Functional Assays and GLI1-Dependent Cancer Cells

Molecules
Aberrant activation of hedgehog (Hh) signaling has been implicated in various cancers. Current FDA-approved inhibitors target the seven-transmembrane receptor Smoothened, but resistance to these drugs has been observed.
Dina Abu Rabe, Lhoucine Chdid, David R. Lamson, Christopher P. Laudeman, Michael Tarpley, Naglaa Elsayed, Ginger R. Smith, Weifan Zheng, Maria S. Dixon, Kevin P. Williams   +9 more
doaj   +1 more source