Results 101 to 110 of about 114,576 (360)

Trafficking, development and hedgehog

Mechanisms of Development, 2009
Embryogenesis is mediated by a relatively small number of developmental signaling pathways, and the morphogens, receptors and transcription factors integral to these cascades are considered the master regulators of development. However, superimposed on this is an additional layer of control by complex intracellular trafficking networks.
Simpson, Fiona, Kerr, Markus C., Wicking, Carol   +2 more
openaire   +4 more sources

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Reasons for admission and rehabilitation rates of various wildlife species in Finland

Frontiers in Veterinary Science
Wildlife rehabilitation is a common part of animal-protection work. In Finland wildlife care is usually based on volunteer work and no licensing or training is required.
Kati White, Kati White, Laura Hänninen, Sanna Sainmaa, Anna Valros   +4 more
doaj   +1 more source

Structural basis for the recognition of Sonic Hedgehog by human Patched1

Science, 2018
The first step in Hedgehog signaling The Hedgehog (Hh) signaling pathway is important in embryogenesis; overactivation is associated with cancer. Central to the pathway is the membrane receptor Patched 1 (Ptch1), which indirectly inhibits a G protein ...
X. Gong, H. Qian, Pingping Cao, Xin Zhao, Qiang Zhou, Jianlin Lei, N. Yan   +6 more
semanticscholar   +1 more source

Single‐Cell Analysis Reveals that Vitamin C Inhibits Bone Metastasis of Renal Cancer via Cell Cycle Arrest and Microenvironment Remodeling

Advanced Science, EarlyView.
3D‐cultured renal cancer cells exhibit stem‐like phenotypes and are more efficient in generating bone metastases. Vitamin C treatment can suppress the development of bone metastasis. Single‐cell transcriptomic analysis reveals that vitamin C inhibits metastasis by inducing tumor cell cycle arrest, suppressing osteoclast differentiation, and reducing ...
Jianye Zhang, Qi Zhang, Gang Lin, Ying Wang, Juan Li, Ping Wang, Jie Qi, Yuan Liang, Shiming He, Yanqing Gong, Ninghan Feng, Yang Wang, Yuanyuan Ma, Mei Zhang, Yue Shi, Xuesong Li, Weimin Ci, Liqun Zhou   +17 more
wiley   +1 more source

Notch and Hedgehog Signalling Axis Drive Senescence in HER2-Positive Breast Cancer Resistant to Trastuzumab

European Journal of Biology
Objective: Cellular senescence halts the proliferation of damaged or preneoplastic cells, playing a vital role in cancer control. In HER2-positive breast cancer, resistance to trastuzumab, a HER2-targeted monoclonal antibody, remains a significant ...
Asiye Büşra Boz Er, İdris Er
doaj   +1 more source

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

Genes & Development, 1999
The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood.
B. St.-Jacques, M. Hammerschmidt, A. McMahon   +2 more
semanticscholar   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Solasonine, A Natural Glycoalkaloid Compound, Inhibits Gli-Mediated Transcriptional Activity

Molecules, 2016
The major obstacle limiting the efficacy of current Smoothened (Smo) inhibitors is the primary and acquired resistance mainly caused by Smo mutations and Gli amplification.
Jun Yang, Wenjing Huang, Wenfu Tan
doaj   +1 more source

RESONANCES ON HEDGEHOG MANIFOLDS

Acta Polytechnica, 2013
We discuss resonances for a nonrelativistic and spinless quantum particle confined to a two- or three-dimensional Riemannian manifold to which a finite number of semiinfinite leads is attached. Resolvent and scattering resonances are shown to coincide in this situation.
Pavel Exner, Jiří Lipovský
openaire   +5 more sources