Results 111 to 120 of about 114,576 (360)

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Osteoblasts in Bone Physiology—Mini Review

Rambam Maimonides Medical Journal, 2012
Bone structural integrity and shape are maintained by removal of old matrix by osteoclasts and in-situ synthesis of new bone by osteoblasts. These cells comprise the basic multicellular unit (BMU).
Orit Rosenberg, Michael Soudry
doaj   +1 more source

Hedgehog Signal and Genetic Disorders

Frontiers in Genetics, 2019
The hedgehog (Hh) family comprises sonic hedgehog (Shh), Indian hedgehog (Ihh), and desert hedgehog (Dhh), which are versatile signaling molecules involved in a wide spectrum of biological events including cell differentiation, proliferation, and ...
Noriaki Sasai, Michinori Toriyama, T. Kondo   +2 more
semanticscholar   +1 more source

Surface Rolling Active Magnetic Emulsions

Advanced Science, EarlyView.
This study presents synergistic combination of materials to augment the life‐like chemotactic abilities of oil droplets towards microrobotics applications. Magnetically actuated autonomous oil droplets possess on‐demand switchable locomotion modalities with augmented navigation in complex confined spaces and can perform cargo transportation.
Muhammad Turab Ali Khan, Gaurav Gardi, Ugur Bozuyuk, Metin Sitti   +3 more
wiley   +1 more source

Hedgehog Signaling Modulates Glial Proteostasis and Lifespan

Cell Reports, 2020
Summary: The conserved Hedgehog signaling pathway has well-established roles in development. However, its function during adulthood remains largely unknown.
Andrew Rallis, Juan A. Navarro, Mathias Rass, Amélie Hu, Serge Birman, Stephan Schneuwly, Pascal P. Thérond   +6 more
doaj  

Evolution of an adaptive behavior and its sensory receptors promotes eye regression in blind cavefish

BMC Biology, 2012
Background How and why animals lose eyesight during adaptation to the dark and food-limited cave environment has puzzled biologists since the time of Darwin.
Yoshizawa Masato, Yamamoto Yoshiyuki, O'Quin Kelly E, Jeffery William R   +3 more
doaj   +1 more source

Bionic Nanostructures Create Mechanical Signals to Mediate the Composite Structural Bone Regeneration Through Multi‐System Regulation

Advanced Science, EarlyView.
Inspired by the structural and functional characteristics of bone, bionic nanomaterials combined with nanotechnology can more accurately replicate stem cell niches, enabling the design of bone tissue engineering scaffolds with diverse nanoscale properties to promote stem cell migration, proliferation, and differentiation. This precise control over stem
Yangfan Pei, Yihan Wang, Jingxia Chen, Jing Zhou, Yuzhu Han, Xiuyu Liu, Siyu Chen, Sheng Chen, Dixin He, Yunxiao Wu, Huixin Lv, Yanmin Zhou   +11 more
wiley   +1 more source

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

Cells, 2018
Hedgehog-GLI (HH) signaling was originally identified as a critical morphogenetic pathway in embryonic development. Since its discovery, a multitude of studies have reported that HH signaling also plays key roles in a variety of cancer types and in ...
Silvia Pietrobono, Barbara Stecca
doaj   +1 more source

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
M. Kinnebrew, Ellen J. Iverson, Bhaven B. Patel, G. Pusapati, Jennifer H. Kong, Kristen A. Johnson, G. Luchetti, Kaitlyn M. Eckert, J. McDonald, D. Covey, C. Siebold, A. Radhakrishnan, R. Rohatgi   +12 more
semanticscholar   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source