Results 131 to 140 of about 62,795 (214)

The Importance of Cancer Stem Cells and Their Pathways in Endometrial Cancer: A Narrative Review. [PDF]

Cells
Caravia LG, Mitranovici MI, Oala IE, Tiron AT, Simionescu AA, Borcan AM, Craina M.   +6 more
europepmc   +1 more source

The dark sides of the GPCR tree ‐ research progress on understudied GPCRs

British Journal of Pharmacology, EarlyView.
Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf, Laura J. Humphrys, Sandra Berndt, Antonella Di Pizio, Juliane Lehmann, Ines Liebscher, Alessandro Nicoli, Masha Y. Niv, Lior Peri, Hannes Schihada, Gunnar Schulte   +10 more
wiley   +1 more source

Correction: Zeng et al. Hedgehog Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling. <i>Cells</i> 2022, <i>11</i>, 1774. [PDF]

Cells
Zeng LH, Barkat MQ, Syed SK, Shah S, Abbas G, Xu C, Mahdy A, Hussain N, Hussain L, Majeed A, Khan KU, Wu X, Hussain M.   +12 more
europepmc   +1 more source

G protein‐coupled receptor‐mediated autophagy in health and disease

British Journal of Pharmacology, EarlyView.
G protein‐coupled receptors (GPCRs) constitute the largest and most diverse superfamily of mammalian transmembrane proteins. These receptors are involved in a wide range of physiological functions and are targets for more than a third of available drugs in the market. Autophagy is a cellular process involved in degrading damaged proteins and organelles
Devrim Öz‐Arslan, Zeynep Aslıhan Durer, Beki Kan   +2 more
wiley   +1 more source

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy. [PDF]

Front Pharmacol
Jin S, Liu X, Cai L, Yan J, Li L, Dong H, Gao Y, Zhu X, Zhang C, Xu X.   +9 more
europepmc   +1 more source

Identification of new small molecules for selective inhibition of SERCA 1 in patient‐derived metastatic papillary thyroid cancer

British Journal of Pharmacology, Volume 182, Issue 11, Page 2392-2408, June 2025.
Abstract Background and Purpose Papillary thyroid cancer (PTC) is a general thyroid cancer subtype; however, PTC is associated with metastasis or recurrence via anti‐cancer drug resistance, rendering it practically incurable. Therefore, effective and reliable clinical approaches are urgently required.
Seok‐Mo Kim, Keunwan Park, Hyeok Jun Yun, Jung Min Kim, Kyung Hwa Choi, Ki Cheong Park   +5 more
wiley   +1 more source

The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer. [PDF]

Sci Signal
Zhang Q, Peng J, Zhang Y, Liu J, He D, Zhao Y, Wang X, Li C, Kong Y, Wang R, Mao F, Wang C, Wang Q, Zhang M, Wang J, Yang HS, Liu X.   +16 more
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Multiple Inflammatory Lesions on the Abdomen: A Quiz. [PDF]

Acta Derm Venereol
Veraldi S, Bortoluzzi P, Germiniasi F.
europepmc   +1 more source

Mefloquine Suppresses Metastasis in Renal Cell Carcinoma Through Targeting SPC25

Cancer Science, Volume 116, Issue 5, Page 1239-1254, May 2025.
We addressed the clinical issue of renal cell carcinoma metastasis by identifying SPC25 protein as a research target through bioinformatics techniques and validation with clinical samples. We comprehensively validated the function of SPC25 protein and determined its impact on renal cancer.
Yongbo Wang, He Wang, Yipeng Xu, Jiawei Ling, Chuhong Zong, Yan Zhang, Xiaoxuan Guo, Guanan Zhao, Yuan Zhou, Jiahui Zhao, Pengrong Lou, Xigao Liu, Tengfei Xu, Qi Ma   +13 more
wiley   +1 more source