Results 181 to 190 of about 114,576 (360)

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

Nature Reviews Clinical Oncology, 2015
N. Takebe, L. Miele, Pamela Jo Harris, W. Jeong, H. Bando, M. Kahn, Sherry X. Yang, S. P. Ivy   +7 more
semanticscholar   +1 more source

Effect of Naringenin on Potassium Bromate–Induced Hepatotoxicity In Vivo: A Dose‐Dependent Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Potassium bromate (PB) is a well‐known additive in the food industry and a byproduct of water treatment. Its long‐term exposure to any form of life exerts mild to severe toxic insults in a dose‐dependent fashion and can even trigger carcinogenesis.
Iftekhar Hassan, Hossam Ebaid, Badar ul Islam, Jameel Al‐Tamimi, Ibrahim M. Alhazza, Altaaf Khan, Ezzat M. Awad   +6 more
wiley   +1 more source

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. [PDF]

, 1996
Christina Alexandre, António Jacinto, Philip W. Ingham   +2 more
openalex   +1 more source

A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka, Ningfeng Tang, Tian Hongying, Kenta Uchibe, Satoru Otsuru, Norimasa Iwasaki, Joshua M. Abzug, Motomi Enomoto‐Iwamoto, Masahiro Iwamoto   +8 more
wiley   +1 more source

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly [PDF]

, 1999
Luisa Nanni, Jeffrey E. Ming, Maureen Bocian, Kathryn A. Steinhaus, Diana W. Bianchi, Christine de Die‐Smulders, Aldo Giannotti, K Imaizumi, Kenneth Lyons Jones, Miguel Del Campo, R. A. Martin, P. Meinecke, Mary Ella Pierpont, Nathaniel H. Robin, I.D. Young, Erich Roessler, Maximilian Muenke   +16 more
openalex   +1 more source

Advances in prognostic biomarkers for biliary atresia: Current insights and future directions

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Biliary atresia (BA) is a progressive, fibrosing cholangiopathy of infancy characterized by inflammatory obstruction of the bile ducts, ultimately leading to end‐stage liver disease if untreated. Early diagnosis and timely surgical intervention via hepatoportoenterostomy (HPE) are critical for improving outcomes; however, prognostication ...
Ahmad Anouti, Pavithra Sudhakara, Chelsea Pratt, Reena Mourya, Lisa VanWagner, Pranavkumar Shivakumar, Sindhu Pandurangi   +6 more
wiley   +1 more source

Modelling erratic dispersal accounting for shifting ice flow geometries: A new method and explanations of erratic dispersal of the British–Irish Ice Sheet

Journal of Quaternary Science, EarlyView.
ABSTRACT Glacial erratics are geologically distinctive rocks transported away from their source area by ice sheets and deposited in lithologically different bedrock areas. They have attracted much scientific curiosity with >24 000 observations across the British Isles.
R. L. Veness, C. D. Clark, J. C. Ely, J. L. Knight, A. Igneczi, S. L. Bradley   +5 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Insights into the Middle Pleistocene fauna of South Africa: Zooarchaeology, stable isotopes and dating of Pniel 6

Journal of Quaternary Science, EarlyView.
ABSTRACT The Florisian Land Mammal Age (FLMA; 773‐12 ka) is characterised by specialist, often extinct, grazing as well as wetland species, many of which are no longer present in the southern African interior. Middle Pleistocene FLMA faunal assemblages are rare, particularly those associated with artefacts, limiting reconstruction of environmental ...
S. Sophia Politt, Helena Pribliczki, Marc R. Dickinson, Nils Andersen, Abenicia Henderson, David Morris, Cheryl A. Makarewicz, Kirsty Penkman, Michaela Ecker   +8 more
wiley   +1 more source

Oral Administration of Trichosanthes Kirilowii Fruit Extract Ameliorates Airway Inflammation and Suppresses Th2 Cell Activities in Ovalbumin‐Sensitized Mice

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Trichosanthes kirilowii is a plant used in traditional Chinese medicine. Its fruits, seeds, and roots can all be used medicinally. The fruit of T. kirilowii has a moistening effect on the lung for arresting cough. However, there is no scientific research to prove that the fruit of T. kirilowii can improve asthma. Herein, we evaluated whether T.
Ting‐Chi Lin, Wen‐Chung Huang, Chwan‐Fwu Lin, Wan‐Ting Chi, Shu‐Chen Cheng, Nai‐Chun Ting, Chian‐Jiun Liou   +6 more
wiley   +1 more source