Results 121 to 130 of about 2,340,031 (328)
Sharpening our understanding of saber‐tooth biomechanics
The Anatomical Record, EarlyView.Abstract Saber‐teeth are a striking example of convergent evolution in vertebrate predators, having evolved multiple times in mammals and their early ancestors. While there is broad consensus that saber‐toothed taxa employed a distinct biting strategy compared to conical‐toothed carnivores, like the lion, the precise mechanics and variability of this ...
Tahlia Pollock, Philip S. L. Anderson
wiley +1 more source
Tuning the Hedgehog pathway [PDF]
Nature Reviews Molecular Cell Biology, 2012 Three recent studies identify mechanisms by which a Hedgehog (HH) gradient can finely tune downstream signalling. HH binding to its receptor leads to the phosphorylation of the transmembrane protein Smoothened (SMO). Li et al. observed that in Drosophila melanogaster the cell surface levels of SMO are downregulated through ubiquitin-mediated ...
openaire +2 more sources
Animal Research and One Health, EarlyView.The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li +5 more
wiley +1 more source
Tobacco Induced Diseases, 2019 Introduction Many studies have shown that COPD is associated with apoptosis of bronchial or alveolar epithelial cells. Alveolar type II epithelial cells (AECII) play an important role in the pathogenetic process.
Jinhua Li +3 more
doaj +1 more source
Scientific Reports, 2017 Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized ...
S. Brilha +5 more
semanticscholar +1 more source
Dynamic Compression Improves Chondrogenesis in the Tissue Engineered Model of Cartilage
Biotechnology and Bioengineering, EarlyView.ABSTRACT Hyaline cartilage is a dense avascular tissue with low regenerative potential, present at the ends of the diarthrodial joints and in the cartilage growth plate. Skeletal diseases often result from extracellular changes in this tissue; however, studies of these are hindered by the tissue complexity, the difficulty in obtaining human material ...
Marc V. Farcasanu +8 more
wiley +1 more source
Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer
Cell Death DiscoveryA sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong +4 more
doaj +1 more source
Lipid metabolism fattens up hedgehog signaling
BMC Biology, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Robert Blassberg, John Jacob
doaj +1 more source
On a functional equation related to a pair of hedgehogs with congruent projections [PDF]
J. Math. Anal. Appl. 445 (2017) 1492-1504, 2016 Hedgehogs are geometrical objects that describe the Minkowski differences of arbitrary convex bodies in the Euclidean space $\mathbb{E}^n$. We prove that two hedgehogs in $\mathbb{E}^n, n \geq 3$, coincide up to a translation and a reflection in the origin, provided that their projections onto any two-dimensional plane are directly congruent and have ...
arxiv
OncoTarget, 2017 Emerging evidence shows that the Hedgehog pathway and the long noncoding RNA TUG1 play pivotal roles in cell proliferation, migration, and invasion in tumors.
Jingjing Li +18 more
semanticscholar +1 more source