Results 141 to 150 of about 2,340,031 (328)
Scientific Reports, 2017 The Hippo pathway is conserved and plays important roles in organ size control. The core components of the Hippo pathway are two kinases Hippo (Hpo), Warts (Wts), and a transcription-co-activator Yorkie (Yki). Yki activity is regulated by phosphorylation,
Ta-Hsing Hsu +5 more
doaj +1 more source
A-expansion for multiple "hedgehog" shapes [PDF]
arXiv, 2016 Overlapping colors and cluttered or weak edges are common segmentation problems requiring additional regularization. For example, star-convexity is popular for interactive single object segmentation due to simplicity and amenability to exact graph cut optimization.
arxiv
Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway [PDF]
, 1997 John C. Sisson +3 more
openalex +1 more source
Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway
OncoTarget, 2017 Genipin, a major component of Gardenia jasminoides Ellis fruit, has been shown to inhibit the growth of gastric, prostate, and breast cancers. However, the anti-proliferative activity of genipin in colorectal cancer (CRC) has not been characterized ...
Bo Ram Kim +10 more
semanticscholar +1 more source
Exploration, EarlyView.Saikosaponin b1 attenuates liver fibrosis by competitively disrupting the interaction between signal transducer and activator of transcription 3 (STAT3) and glioma‐associated oncogene‐1 (Gli1) in the activated hepatic stellate cells (HSCs). The blocked interaction of STAT3 and Gli1 promotes the degradation of Gli1, inhibits Gli1 transcriptional ...
Meiyu Shao +15 more
wiley +1 more source
Exploration, EarlyView.Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface‐microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and ...
Yuhan Du +7 more
wiley +1 more source
Frontiers in PharmacologyIntroductionLiver fibrosis is a significant global health burden that lacks effective therapies. It can progress to cirrhosis and hepatocellular carcinoma (HCC).
Amir Mohamed Abdelhamid +24 more
doaj +1 more source
Radial Symmetry on 3D Shells in the Landau-de Gennes Theory [PDF]
arXiv, 2014 We study the stability of the radial-hedgehog solution on a three-dimensional (3D) spherical shell with radial boundary conditions, within the Landau-de Gennes theory for nematic liquid crystals. We show that the radial-hedgehog solution has no zeroes for a sufficiently narrow shell, for all temperatures below the nematic supercooling temperature.
arxiv
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
Beilstein Journal of Organic Chemistry, 2012 Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che +8 more
doaj +1 more source