Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]
Open Biology, 2021 Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
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Hedgehog proteins create a dynamic cholesterol interface. [PDF]
PLoS ONE, 2021 During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation.
Amirhossein Mafi +10 more
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Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification [PDF]
JOR Spine, 2019 Parathyroid hormone‐related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown.
Frances C. Bach +9 more
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Computational investigation of naturally occurring anticancer agents in regulating Hedgehog pathway proteins. [PDF]
PLoS ONEEmbryonic development in humans is controlled by the Hedgehog pathway, which becomes inactive in mature tissues. Except for tissue maintenance and healing, activation of this pathway results in tumorigenesis with only a few exceptions.
Renu Pai +3 more
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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy [PDF]
Frontiers in PharmacologyBackgroundItraconazole, a widely used antifungal medication, has shown potential in inhibiting tumor growth and reducing angiogenesis. However, its role in melanoma tumor growth remains insufficiently explored.
Shunqiao Jin +12 more
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Frontiers in Dental Medicine, 2021 This study aimed to elucidate the role of the Sonic hedgehog (Shh)–Patched (Ptch)–Gli signaling pathway in maintaining dental epithelial and pulp stem/progenitor cells and regulating the function of odontoblasts.
Yuko Ishikawa +4 more
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Frontiers in Cell and Developmental Biology, 2023 Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear.
Hiroki Hagizawa +7 more
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
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