Results 1 to 10 of about 1,401 (218)
Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease [PDF]
Open Biology, 2021 Hedgehog acyltransferase (Hhat), a member of the membrane-bound O-acyltransferase (MBOAT) family, catalyses the covalent attachment of palmitate to the N-terminus of Hedgehog proteins.
Marilyn D. Resh
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Frontiers in Dental Medicine, 2021 This study aimed to elucidate the role of the Sonic hedgehog (Shh)–Patched (Ptch)–Gli signaling pathway in maintaining dental epithelial and pulp stem/progenitor cells and regulating the function of odontoblasts.
Yuko Ishikawa +4 more
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Frontiers in Cell and Developmental Biology, 2023 Objective: The nucleus pulposus (NP) comprises notochordal NP cells (NCs) and chondrocyte-like NP cells (CLCs). Although morphological similarities between CLCs and chondrocytes have been reported, interactions between CLCs and NCs remain unclear.
Hiroki Hagizawa +7 more
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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Hedgehog proteins create a dynamic cholesterol interface.
PLoS ONE, 2021 During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation.
Amirhossein Mafi +10 more
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Gli Proteins: Regulation in Development and Cancer
Cells, 2019 Gli proteins are transcriptional effectors of the Hedgehog signaling pathway. They play key roles in the development of many organs and tissues, and are deregulated in birth defects and cancer. We review the molecular mechanisms of Gli protein regulation
Paweł Niewiadomski +5 more
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Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer. [PDF]
PLoS ONE, 2013 Hedgehog is an evolutionarily conserved developmental pathway, widely implicated in controlling various cellular responses such as cellular proliferation and stem cell renewal in human and other organisms, through external stimuli. Aberrant activation of
Saikat Chowdhury +2 more
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Manipulation of Sonic Hedgehog Signaling Pathway in Maintenance, Differentiation, and Endocrine Activity of Insulin-Producing Cells: A Systematic Review [PDF]
Iranian Journal of Medical SciencesBackground: Some studies have evaluated the manipulation of the sonic hedgehog (Shh) signaling pathway to generate more efficient insulin-producing cells (IPCs).
Dian Dayer, Vahid Bayati, Mina Ebrahimi
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
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PLoS Biology, 2013 Hedgehog signaling plays conserved roles in controlling embryonic development; its dysregulation has been implicated in many human diseases including cancers.
Shoujun Huang +16 more
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