Results 11 to 20 of about 93,686 (252)
Palmitoylation of Hedgehog proteins. [PDF]
Vitam Horm, 2012 Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
Buglino JA, Resh MD.
europepmc +4 more sources
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling [PDF]
Nature Communications, 2021 AbstractHedgehog (HH) morphogen signalling, crucial for cell growth and tissue patterning in animals, is initiated by the binding of dually lipidated HH ligands to cell surface receptors. Hedgehog-Interacting Protein (HHIP), the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling, binds directly to SHH with high nanomolar affinity ...
Samuel C. Griffiths +11 more
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Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein [PDF]
Journal of Biological Chemistry, 2014 Hedgehog proteins are secreted morphogens that play critical roles in development and disease. During maturation of the proteins through the secretory pathway, they are modified by the addition of N-terminal palmitic acid and C-terminal cholesterol moieties, both of which are critical for their correct function and localization.
Antonio D. Konitsiotis +6 more
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Cholesterol modification of Hedgehog family proteins [PDF]
Journal of Clinical Investigation, 2002 The Hedgehog (Hh) gene family encodes a group of secreted signaling molecules that are essential for growth and patterning of many different body parts of vertebrate and invertebrate embryos (1). Depending on the context, Hh signals can promote cell proliferation, prevent apoptosis, or induce specific cell fates.
Juhee, Jeong, Andrew P, McMahon
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The evolutionary origin of hedgehog proteins [PDF]
Current Biology, 2007 SummaryAnimal development is orchestrated largely by diffusible ligands of the Wnt, TGF-β, hedgehog (Hh) and FGF signaling pathways, as well as cell-surface molecules, such as Notch, cadherins, integrins and the immunoglobulin-like proteins [1,2]. Here, we show that Hh proteins are likely to have evolved very early in metazoan evolution by domain ...
Adamska, M. +6 more
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Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP [PDF]
Nature Structural & Molecular Biology, 2009 Hedgehog (Hh) morphogens have fundamental roles in development, whereas dysregulation of Hh signaling leads to disease. Multiple cell-surface receptors are responsible for transducing and/or regulating Hh signals. Among these, the Hedgehog-interacting protein (Hhip) is a highly conserved, vertebrate-specific inhibitor of Hh signaling.
Bishop, Benjamin +5 more
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The Hedgehog protein family [PDF]
Genome Biology, 2008 The Hedgehog (Hh) pathway is one of the fundamental signal transduction pathways in animal development and is also involved in stem-cell maintenance and carcinogenesis. The hedgehog (hh) gene was first discovered in Drosophila, and members of the family have since been found in most metazoa.
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Loss of Sonic hedgehog leads to alterations in intestinal secretory cell maturation and autophagy. [PDF]
PLoS ONE, 2014 Intestinal epithelial cells express the Sonic and Indian hedgehog ligands. Despite the strong interest in gut hedgehog signaling in GI diseases, no studies have specifically addressed the singular role of intestinal epithelial cell Sonic hedgehog ...
Jessica Gagné-Sansfaçon +4 more
doaj +1 more source
Sonic Hedgehog Is a Member of the Hh/DD-Peptidase Family That Spans the Eukaryotic and Bacterial Domains of Life. [PDF]
, 2018 Sonic Hedgehog (Shh) coordinates Zn2+ in a manner that resembles that of peptidases. The ability of Shh to undergo autoproteolytic processing is impaired in mutants that affect the Zn2+ coordination, while mutating residues essential for catalytic ...
Roelink, Henk
core +3 more sources
Cryo-EM structure of the Hedgehog release protein Dispatched [PDF]
Science Advances, 2020 Structure of the Drosophila melanogaster Hedgehog release protein Dispatched reveals an open conformation of its ectodomain.
Fabien Cannac +5 more
openalex +4 more sources