Results 11 to 20 of about 1,401 (218)

Hedgehog morphogen gradient is robust towards variations in tissue morphology in Drosophila

Scientific Reports, 2023
During tissue development, gradients of secreted signaling molecules known as morphogens provide cells with positional information. The mechanisms underlying morphogen spreading have been widely studied, however, it remains largely unexplored whether the
Giulia Pierini, Christian Dahmann
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Hedgehog pathway inhibitors – current status and future prospects

Infectious Agents and Cancer, 2012
The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar, Alvi Arsalan, Aslam Hafiz, Haseeb Abdul   +3 more
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Hedgehog proteins and parathyroid hormone‐related protein are involved in intervertebral disc maturation, degeneration, and calcification

JOR Spine, 2019
Parathyroid hormone‐related protein (PTHrP) and hedgehog signaling play an important role in chondrocyte development, (hypertrophic) differentiation, and/or calcification, but their role in intervertebral disc (IVD) degeneration is unknown.
Frances C. Bach, Kim M. deRooij, Frank M. Riemers, Joseph W. Snuggs, Willem A. M. deJong, Ying Zhang, Laura B. Creemers, Danny Chan, Christine Le Maitre, Marianna A. Tryfonidou   +9 more
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Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

PLoS ONE, 2014
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat ...
Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee   +8 more
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Canonical Sonic Hedgehog Signaling in Early Lung Development

Journal of Developmental Biology, 2017
The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall,
Hugo Fernandes-Silva, Jorge Correia-Pinto, Rute Silva Moura   +2 more
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Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]

PLoS ONE, 2014
Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim, Elaine Y C Hsia, James Kim, Navdar Sever, Philip A Beachy, Xiaoyan Zheng   +5 more
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A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened. [PDF]

PLoS Genetics, 2011
Many signaling proteins including G protein-coupled receptors localize to primary cilia, regulating cellular processes including differentiation, proliferation, organogenesis, and tumorigenesis.
Seongjin Seo, Qihong Zhang, Kevin Bugge, David K Breslow, Charles C Searby, Maxence V Nachury, Val C Sheffield   +6 more
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Mechanism of exosomal miR-155 derived from bone marrow mesenchymal stem cells on stemness maintenance and drug resistance in myeloma cells

Journal of Orthopaedic Surgery and Research, 2021
Objective This study was to explore the effect of exosomal miR-155 derived from bone marrow mesenchymal stem cells (BMSCs) on stemness maintenance and drug resistance in MPC-11 multiple myeloma cells.
Xinyu Gao, Jin Zhou, Jinghua Wang, Xiushuai Dong, Yuying Chang, Yinglan Jin   +5 more
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Intein Inhibitors as Novel Antimicrobials: Protein Splicing in Human Pathogens, Screening Methods, and Off-Target Considerations

Frontiers in Molecular Biosciences, 2021
Protein splicing is a post-translational process by which an intervening polypeptide, or intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with extein ligation. Although inteins are highly abundant in the microbial
Diana A. Wall, Seanan P. Tarrant, Chunyu Wang, Chunyu Wang, Kenneth V. Mills, Christopher W. Lennon   +5 more
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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

eLife, 2019
Previously we proposed that transmission of the hedgehog signal across the plasma membrane by Smoothened is triggered by its interaction with cholesterol (Luchetti et al., 2016).
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi   +12 more
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