Results 21 to 30 of about 100,157 (319)

Membrane targeting of palmitoylated Wnt and Hedgehog revealed by chemical probes [PDF]

, 2011
Palmitoylation of the Wnt and Hedgehog proteins is critical for maintaining their physiological functions. To date, there are no reported studies that characterize the cellular distribution of the palmitoylated forms of these proteins.
Arenas-Ramirez, Natalia, Gao, Xinxin, Hannoush, Rami N., Scales, Suzie J.   +3 more
core   +1 more source

Hedgehog pathway inhibitors – current status and future prospects

Infectious Agents and Cancer, 2012
The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar, Alvi Arsalan, Aslam Hafiz, Haseeb Abdul   +3 more
doaj   +1 more source

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish [PDF]

, 2010
Background: In mammalian cells, the integrity of the primary cilium is critical for proper regulation of the Hedgehog (Hh) signal transduction pathway.
Ingham, P.W., Kim, H.R., Richardson, J., van Eeden, F.   +3 more
core   +3 more sources

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Flinspach, Armin Niklas, Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Warzecha, Jörg, Wenger, Florian   +5 more
core   +1 more source

Simultaneous measurement of smoothened entry into and exit from the primary cilium. [PDF]

PLoS ONE, 2014
Ciliary accumulation of signaling proteins must result from a rate of ciliary entry that exceeds ciliary exit, but approaches for distinguishing ciliary entry vs. exit are lacking.
Jynho Kim, Elaine Y C Hsia, James Kim, Navdar Sever, Philip A Beachy, Xiaoyan Zheng   +5 more
doaj   +1 more source

Wnt, notch, and TGF-β pathways impinge on hedgehog signaling complexity: an open window on cancer [PDF]

, 2019
Constitutive activation of the Hedgehog (Hh) signaling pathway is associated with increased risk of developing several malignancies. The biological and pathogenic importance of Hh signaling emphasizes the need to control its action tightly, both ...
Bellavia, Diana, Checquolo, Saula, Nardozza, Francesca, Pelullo, Maria, Screpanti, Isabella, Zema, Sabrina   +5 more
core   +1 more source

Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells.

PLoS ONE, 2014
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their N-terminus by the MBOAT family multispanning membrane enzyme Hedgehog acyltransferase (Hhat ...
Antonios D Konitsiotis, Shu-Chun Chang, Biljana Jovanović, Paulina Ciepla, Naoko Masumoto, Christopher P Palmer, Edward W Tate, John R Couchman, Anthony I Magee   +8 more
doaj   +1 more source

Functional divergence in the role of N-linked glycosylation in smoothened signaling [PDF]

, 2015
The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have ...
A Helenius, A Ruiz i Altaba, AG Soto, AG Soto, AH Polizio, AH Polizio, AJ Petrescu, AJ Zhu, AM Wilbanks, Angela M. Arensdorf, Ashley Truong, B Sivertsen, BJ Arey, BR Myers, C Torroja, C Wang, C Wang, CE Carroll, D Maier, D Nedelcu, D Rendie, D Shi, Daniel P. Stewart, David J. Robbins, DJ Casso, DJ Robbins, DM Stone, Edgar Angelats, F Landomiel, F Shen, G Navarro, Gemma Navarro, H Sasaki, J Alcedo, J Bischof, J Briscoe, J He, J Taipale, J Taipale, JD Violin, JJ Kovacs, JK Chen, JK Chen, Joseph T. Opferman, JP Incardona, KC Corbit, L Zhou, LW McGinnes, M Murone, M van den Heuvel, M Wheatley, MF Tansky, MT Barakat, N Denef, NA Riobo, Peter J. McCormick, PM Lanctot, PW Ingham, R Rana, R Rohatgi, R Rohatgi, R Schroder, R Schroder, R Teperino, R Xia, Rajat Rohatgi, RT Strachan, S Li, S Marada, S Mukhopadhyay, S Nachtergaele, S Nachtergaele, S Rajagopal, S Yao, Sigrid Nachtergaele, SK Ogden, Stacey K. Ogden, Suresh Marada, T Von Ohlen, V Marigo, X Lu, Y Nakano, Y Zhao, YH Belgacem   +83 more
core   +3 more sources

Canonical Sonic Hedgehog Signaling in Early Lung Development

Journal of Developmental Biology, 2017
The canonical hedgehog (HH) signaling pathway is of major importance during embryonic development. HH is a key regulatory morphogen of numerous cellular processes, namely, cell growth and survival, differentiation, migration, and tissue polarity. Overall,
Hugo Fernandes-Silva, Jorge Correia-Pinto, Rute Silva Moura   +2 more
doaj   +1 more source

Simulations demonstrate a simple network to be sufficient to control branch point selection, smooth muscle and vasculature formation during lung branching morphogenesis [PDF]

G. Celli\`ere, D Menshykau and Dagmar Iber (2012) Biology Open 1, 775-788, 2012
Proper lung functioning requires not only a correct structure of the conducting airway tree, but also the simultaneous development of smooth muscles and vasculature. Lung branching morphogenesis is strongly stereotyped and involves the recursive use of only three modes of branching.
arxiv   +1 more source