Results 11 to 20 of about 97,185 (156)
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]
, 2019 Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J. +7 more
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Hedgehog Signaling in Myeloid Malignancies [PDF]
Cancers, 2021 Myeloid malignancies arise from normal hematopoiesis and include several individual disorders with a wide range of clinical manifestations, treatment options, and clinical outcomes. The Hedgehog (HH) signaling pathway is aberrantly activated in many of these diseases, and glasdegib, a Smoothened (SMO) antagonist and HH pathway inhibitor, has recently ...
Ajay Abraham, William Matsui
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Hedgehog Signaling in Hematopoiesis [PDF]
Critical Reviews™ in Eukaryotic Gene Expression, 2010 The Hedgehog signaling pathway is highly conserved and plays an essential role in the embryonic development of a wide variety of organs. In adult tissues, such as the central nervous system, it may also be required for homeostasis and repair following injury. The role of Hedgehog signaling in regulating hematopoiesis is not entirely clear. Evidence has
William Matsui, Yiting Lim
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Localized JNK signaling regulates organ size during development. [PDF]
, 2016 A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Beachy, Philip A +5 more
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Hedgehog signaling in cholangiocytes [PDF]
Current Opinion in Gastroenterology, 2011 Cells lining the biliary tree are targets of injury, but also orchestrate liver repair. The latter involves autocrine/paracrine signaling that enhances the viability and growth of residual ductular cells and promotes accumulation of inflammatory and myofibroblastic cells.
Alessia Omenetti, Anna Mae Diehl
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Patched receptors sense, interpret and establish an epidermal Hedgehog signalling gradient [PDF]
, 2016 By using the sensitivity of single-molecule fluorescent in situ hybridization, we have precisely quantified the levels and defined the temporal and spatial distribution of Hedgehog signaling activity during embryonic skin development and discovered that ...
Adolphe, Christelle +4 more
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Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling [PDF]
, 2014 Oxysterols bind the seven-spanner transmembrane protein Smoothened and potently activate vertebrate Hedgehog signaling, a pathway essential in embryonic development, adult stem cell maintenance and cancer.
Jao, Cindy +4 more
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Transducing the Hedgehog Signal [PDF]
Cell, 2000 Regardless of the status of Smo/Ptc associations, we now have to consider which, if any, of the newly found responses of Smo to Hh actually determine Smo signaling activity. As there really are no definitive data to guide us here, I will take the opportunity to discuss some possibilities.
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Noncanonical Hedgehog Signaling [PDF]
, 2012 The notion of noncanonical hedgehog (Hh) signaling in mammals has started to receive support from numerous observations. By noncanonical, we refer to all those cellular and tissue responses to any of the Hh isoforms that are independent of transcriptional changes mediated by the Gli family of transcription factors.
My G. Mahoney +4 more
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Lipid metabolism fattens up hedgehog signaling [PDF]
, 2017 Signaling pathways direct organogenesis, often through concentration-dependent effects on cells. The hedgehog pathway enables cells to sense and respond to hedgehog ligands, of which the best studied is sonic hedgehog. Hedgehog signaling is essential for
Blassberg, R, Jacob, John
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