Results 251 to 260 of about 113,623 (349)

The role of vitamin D receptor signaling in hair follicle health and alopecia: Current understanding and therapeutic implications

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
The vitamin D receptor (VDR) regulates hair follicle biology through ligand‐dependent and ligand‐independent mechanisms by heterodimerizing with retinoid X receptor, recruiting coactivator complexes, and activating target genes including Wnt inhibitors, hair keratins, and cell cycle regulators.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Oral <i>Prevotella</i> induces fat taste impairment, visceral lipid accumulation and insulin resistance by downregulating Hedgehog signaling in taste buds. [PDF]

J Oral Microbiol
Liu X, Zhang J, He Y, Zhang Q, Du S, Zeng T, Zhang J, Zhang H, Luo H, Li H, Wang Y, Peng M, Zhang N, Chen Q, Huang H, Wang P, Chen L, Hu X.   +17 more
europepmc   +1 more source

The role of cytokines in ovarian cancer drug resistance

International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang, Yunxia Zang, Rebeka Dejenie, Junyuan Bing, Shixia Dong, Yanfei Zhang, Yi Zhu, Jingjing Li   +7 more
wiley   +1 more source

Gas1 regulates embryonic tongue muscle proliferation, differentiation and maturation via alternative pathways to Hedgehog signaling. [PDF]

Development
Audu GC, Rohan SY, Kumari A.
europepmc   +1 more source

An Anoikis Resistance Phenotype Converged to Immune Dysfunction and Resistance to Immune Checkpoint Blockades in Gastric Cancer

Cancer Innovation, Volume 5, Issue 1, February 2026.
Gastric cancer (GC) has high global incidence and mortality, with most cases diagnosed at advanced stages. Immunotherapy, particularly immune checkpoint blockers (ICBs), has shown promise, but not all patients benefit. This study applied consensus clustering based on anoikis‐related genes (ANRGs) to classify GC into two subclusters.
Xing Cai, Jinru Yang, Fangyuan Zhang, Fuwang Xu, Yuan Fang, Zongbi Yi   +5 more
wiley   +1 more source

Targeting Hedgehog Signalling as a Drug Therapy in Aggressive Fibromatosis

, 2012
Ronak Ghanbari Azarnier
openalex   +1 more source

BBS8-dependent ciliary Hedgehog signaling governs cell fate in the white adipose tissue. [PDF]

EMBO J
Sieckmann K, Winnerling N, Silva Ribeiro DJ, Yüksel S, Kardinal R, Steinheuer LM, Frechen F, Corrêa LH, Schermann G, Klausen C, Blank-Stein N, Schulte-Schrepping J, Osei-Sarpong C, Becker M, Bonaguro L, Beyer M, May-Simera HL, Zurkovic J, Thiele C, Thurley K, Sorokin L, Ruiz de Almodovar C, Mass E, Wachten D.   +23 more
europepmc   +1 more source

CRISPR‐Cas9‐Generated TXNDC15 c.560delA Homozygous Mouse Model Exhibits Meckel–Gruber Syndrome Phenotype

genesis, Volume 64, Issue 1, February 2026.
ABSTRACT To determine whether TXNDC15 variation causes Meckel–Gruber syndrome (MKS), we assessed the pathogenicity of the frameshift variant c.560delA. A CRISPR–Cas9 generated mouse model carrying the equivalent Txndc15 c.512delA mutation was analyzed at embryonic day 15.5.
Yang Liu, Hui Wang, Liyuan Chen, Xiaoxia Wu, Zhiyong Xu, Qingfa Huang, Hu Zhang, Xiushu Cao, Xinyuan Liang, Xingjian Zhong, Caiqun Luo   +10 more
wiley   +1 more source

PHGDH drives 5-FU chemoresistance in colorectal cancer through the Hedgehog signaling. [PDF]

J Exp Clin Cancer Res
Mancini C, Lori G, Mattei G, Iozzo M, Desideri D, Cianchi F, Fortuna L, Passagnoli F, Massi D, Ugolini F, Messerini L, Piscuoglio S, Pezone A, Magherini F, Biagioni A, Lottini T, Zambardino D, Truglio GI, Petricci E, Magi A, Arcangeli A, Maresca L, Stecca B, Pranzini E, Taddei ML.   +24 more
europepmc   +1 more source

A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis

Glia, Volume 74, Issue 2, February 2026.
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil, Marina R. Hanna, Vivian Gama   +2 more
wiley   +1 more source