Results 1 to 10 of about 51,121 (302)

Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer [PDF]

Cell Death Discovery
A sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong, Xingyu Zhu, Xin Ru Chen, Hao Chen, Wei Chong   +4 more
doaj   +2 more sources

A novel prognostic model for Hedgehog signaling pathway-related genes predicts the prognosis of hepatocellular carcinoma [PDF]

Frontiers in Oncology
BackgroundThe Hedgehog signaling pathway is involved in the carcinogenesis and development of hepatocellular carcinoma(HCC); however, few studies on the prognostic model of the Hedgehog signaling pathway have been found.MethodsFirst, we selected 56 ...
Ting Liu, Yang Wang
doaj   +2 more sources

Fibrotic scar formation after cerebral ischemic stroke: Targeting the Sonic hedgehog signaling pathway for scar reduction [PDF]

Neural Regeneration Research
Recent studies have shown that fibrotic scar formation following cerebral ischemic injury has varying effects depending on the microenvironment. However, little is known about how fibrosis is induced and regulated after cerebral ischemic injury.
Jun Wen, Hao Tang, Mingfen Tian, Ling Wang, Qinghuan Yang, Yong Zhao, Xuemei Li, Yu Ren, Jiani Wang, Li Zhou, Yongjun Tan, Haiyun Wu, Xinrui Cai, Yilin Wang, Hui Cao, Jianfeng Xu, Qin Yang   +16 more
doaj   +2 more sources

Targeting the hedgehog signaling pathway to improve tendon-to-bone integration. [PDF]

Osteoarthritis Cartilage, 2023
Kamalitdinov TB, Fujino K, Keith Lang S, Jiang X, Madi R, Evans MK, Zgonis MH, Kuntz AF, Dyment NA.   +8 more
europepmc   +3 more sources

Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway [PDF]

Frontiers in Neuroscience
Hedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in
Tadashi Shiohama, Hideki Uchikawa, Hideki Uchikawa, Nobuhiro Nitta, Nobuhiro Nitta, Tomozumi Takatani, Shingo Matsuda, Shingo Matsuda, Shingo Matsuda, Alpen Ortug, Alpen Ortug, Emi Takahashi, Emi Takahashi, Daisuke Sawada, Eiji Shimizu, Katsunori Fujii, Katsunori Fujii, Ichio Aoki, Hiromichi Hamada   +18 more
doaj   +2 more sources

MYB Activates the Hedgehog Signaling Pathway to Repress Natural Killer Cytotoxicity in Cervical Cancer [PDF]

Kaohsiung Journal of Medical Sciences
Natural killer (NK) cells present in the tumor microenvironment serve as a critical line of defense against various malignancies, including cervical cancer.
Yu Wang, Chen Li
doaj   +2 more sources

BushenHuoxue formula promotes osteogenic differentiation via affecting Hedgehog signaling pathway in bone marrow stem cells to improve osteoporosis symptoms. [PDF]

PLoS One, 2023
Chen Y, Wei Z, Shi H, Wen X, Wang Y, Wei R.   +5 more
europepmc   +2 more sources

More Surprises in the Hedgehog Signaling Pathway [PDF]

Cell, 2000
The author regrets that, owing to severe space limitations, key pieces of work have been cited using reviews rather than the original articles.
Andrew P. McMahon
openalex   +3 more sources

Cannabidiol exerts teratogenic effects on developing zebrafish through the sonic hedgehog signaling pathway. [PDF]

Sci Rep
Razmara P, Son HW, Ali DW.
europepmc   +3 more sources

Proteostasis in the Hedgehog signaling pathway

Seminars in Cell & Developmental Biology, 2018
The Hedgehog (Hh) signaling pathway is crucial for the development of vertebrate and invertebrate animals alike. Hh ligand binds its receptor Patched (Ptc), allowing the activation of the obligate signal transducer Smoothened (Smo). The levels and localizations of both Ptc and Smo are regulated by ubiquitination, and Smo is under additional regulation ...
Aimin Liu
openalex   +5 more sources