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Mechanisms and therapeutic potential of the hedgehog signaling pathway in cancer [PDF]
Cell Death DiscoveryA sort of major malignant disease, cancer can compromise human health wherever. Some mechanisms of the occurrence and evolution of cancer still seem elusive even now. Consequently, the therapeutic strategies for cancer must continually evolve.
Ge Cong +4 more
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Brain morphological analysis in mice with hyperactivation of the hedgehog signaling pathway [PDF]
Frontiers in NeuroscienceHedgehog signaling is a highly conserved pathway that plays pivotal roles in morphogenesis, tumorigenesis, osteogenesis, and wound healing. Previous investigations in patients with Gorlin syndrome found low harm avoidance traits, and increased volumes in
Tadashi Shiohama +18 more
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Chemically modified small interfering RNA targeting Hedgehog signaling pathway for rheumatoid arthritis therapy [PDF]
Molecular Therapy: Nucleic Acids, 2023 Rheumatoid arthritis (RA) is an inflammatory disease that leads to disability; however, existing therapies are still unsatisfactory. Activated fibroblast-like synoviocytes (FLSs) play an essential role in synovitis formation and joint destruction in RA ...
Lang Lin +4 more
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Plexins promote Hedgehog signaling through their cytoplasmic GAP activity
eLife, 2022 Hedgehog signaling controls tissue patterning during embryonic and postnatal development and continues to play important roles throughout life. Characterizing the full complement of Hedgehog pathway components is essential to understanding its wide ...
Justine M Pinskey +7 more
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Cells, 2022 The Hedgehog signaling pathway regulates many processes during embryogenesis and the homeostasis of adult organs. Recent data suggest that central metabolic processes and signaling cascades in the liver are controlled by the Hedgehog pathway and that ...
Fritzi Ott +12 more
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The you gene encodes an EGF-CUB protein essential for Hedgehog signaling in zebrafish. [PDF]
PLoS Biology, 2005 Hedgehog signaling is required for many aspects of development in vertebrates and invertebrates. Misregulation of the Hedgehog pathway causes developmental abnormalities and has been implicated in certain types of cancer.
Ian G Woods, William S Talbot
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
Communications Biology, 2021 By modulating the activation state of the Hedgehog pathway, de la Rocha-Muñoz et al demonstrate that Hedgehog signaling controls the expression and transport activity of the neuronal glycine transporter GlyT2.
Andrés de la Rocha-Muñoz +8 more
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Topological transport of deconfined hedgehogs in magnets [PDF]
Phys. Rev. Lett. 125, 267201 (2020), 2020 We theoretically investigate the dynamics of magnetic hedgehogs, which are three-dimensional topological spin textures that exist in common magnets, focusing on their transport properties and connections to spintronics. We show that fictitious magnetic monopoles carried by hedgehog textures obey a topological conservation law, based on which a ...
arxiv +1 more source
Frontiers in Endocrinology, 2023 Hedgehog signaling plays pivotal roles in embryonic development, adult homeostasis and tumorigenesis. However, its engagement in the pituitary gland has been long underestimated although Hedgehog signaling and pituitary embryogenic development are ...
Yehan Bian, Heidi Hahn, Anja Uhmann
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Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]
PLoS ONE, 2011 TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita +8 more
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