Results 11 to 20 of about 3,054 (263)
Prostate cancer and Hedgehog signalling pathway [PDF]
Clinical and Translational Oncology, 2007 The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Luis M. Antón Aparicio +6 more
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The role of kinases in the Hedgehog signalling pathway [PDF]
EMBO reports, 2008 The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila, many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the regulation of Hh signal transduction is unclear.
Reid Aikin +2 more
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Drugging Hedgehog: signaling the pathway to translation [PDF]
BMC Biology, 2013 First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic
Thomas J. Carney, Philip W. Ingham
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Molecular Pathways: The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2012 AbstractThe Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target pathogenic Hh signaling have steadily progressed from the laboratory to the clinic, and the recent approval of the Hh pathway inhibitor vismodegib for patients with advanced basal cell ...
Ross McMillan, William Matsui
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The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2006 AbstractThe Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway
Hua Tian +2 more
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The Hedgehog Signaling Pathway in Ischemic Tissues [PDF]
International Journal of Molecular Sciences, 2019 Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the
Giarretta I. +5 more
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Hedgehog Signaling Pathway in Ovarian Cancer [PDF]
International Journal of Molecular Sciences, 2013 Despite advances in surgical and chemotherapeutic treatment options, less than 50% of patients with advanced-stage ovarian cancer survive five years after initial diagnosis. In this regard, novel treatment approaches are warranted utilizing molecularly targeted therapies directed against particular components of specific signaling pathways which are ...
Joanna Szkandera +4 more
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Hedgehog Signaling Pathway and Lung Cancer [PDF]
Journal of Thoracic Oncology, 2007 Signaling pathways responsible for embryogenesis play a critical role in the maintenance of stem cells in adult life and cellular responses to injury. Dysfunction of the developmental signaling pathways during adult homeostasis leads to various events resulting in the development of neoplasia. We review the biology of the hedgehog signaling pathway and
Ramaswamy Govindan, Vamsidhar Velcheti
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Hedgehog Signaling Pathway and Autophagy in Cancer [PDF]
International Journal of Molecular Sciences, 2018 Hedgehog (Hh) pathway controls complex developmental processes in vertebrates. Abnormal activation of Hh pathway is responsible for tumorigenesis and maintenance of multiple cancers, and thus addressing this represents promising therapeutic opportunities. In recent years, two Hh inhibitors have been approved for basal cell carcinoma (BCC) treatment and
Zeng, X., Ju, D.
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