Results 11 to 20 of about 247,901 (376)
Prostate cancer and Hedgehog signalling pathway [PDF]
Clinical and Translational Oncology, 2007 The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Luis M. Antón Aparicio +6 more
openalex +4 more sources
The role of kinases in the Hedgehog signalling pathway [PDF]
EMBO reports, 2008 The Hedgehog (Hh) signalling pathway has a crucial role in several developmental processes and is aberrantly activated in a variety of cancers. In Drosophila, many of the canonical Hh pathway components are phosphorylated, yet the precise role of these phosphorylation events in the regulation of Hh signal transduction is unclear.
Reid Aikin +2 more
openalex +4 more sources
The Sonic Hedgehog Pathway Stimulates Prostate Tumor Growth by Paracrine Signaling and Recaptures Embryonic Gene Expression in Tumor Myofibroblasts [PDF]
, 2009 The Hedgehog (Hh) pathway contributes to prostate cancer growth and progression. The presence of robust Shh expression in both normal prostate and localized cancer challenged us to explain the unique growth promoting effect in cancer.
Aubie Shaw, Jerry J. Gipp, Wade Bushman
openalex +4 more sources
Drugging Hedgehog: signaling the pathway to translation [PDF]
BMC Biology, 2013 First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this pathway, published in 2002, opened a new chapter in the quest to translate the results of basic developmental biology research into therapeutic
Thomas J. Carney, Philip W. Ingham
openalex +5 more sources
Molecular Pathways: The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2012 AbstractThe Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target pathogenic Hh signaling have steadily progressed from the laboratory to the clinic, and the recent approval of the Hh pathway inhibitor vismodegib for patients with advanced basal cell ...
Ross McMillan, William Matsui
openalex +5 more sources
Editorial: Hedgehog signaling pathway in development and cancer. [PDF]
Front Cell Dev Biol, 2022 Cheng SY, Lauth M, Liu A.
europepmc +4 more sources
The Hedgehog Signaling Pathway in Cancer [PDF]
Clinical Cancer Research, 2006 AbstractThe Hedgehog (Hh) pathway is a signaling cascade that directs patterning in most animals and is crucial for proper development. At the molecular level, Hh ligands drive cell proliferation in some cell types while causing others to undergo differentiation. Hh signaling is most active during embryogenesis, and aberrant reactivation of the pathway
Hua Tian +2 more
openaire +5 more sources
Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium. [PDF]
, 2009 Activation of Hedgehog (Hh) signaling requires the transmembrane protein Smoothened (Smo), a member of the G-protein coupled receptor superfamily. In mammals, Smo translocates to the primary cilium upon binding of Hh ligands to their receptor, Patched ...
Chen, Miao-Hsueh +2 more
core +12 more sources
The Hedgehog Signaling Pathway in Ischemic Tissues [PDF]
International Journal of Molecular Sciences, 2019 Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the
Giarretta I. +5 more
openaire +3 more sources