Results 21 to 30 of about 51,121 (302)

Prostate cancer and Hedgehog signalling pathway [PDF]

Clinical and Translational Oncology, 2007
The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, patterning and morphogenesis of many different regions within the bodies of vertebrates.
Antón-Aparicio, Luis M., García Campelo, Rosario, Casinello Espinosa, J., Valladares-Ayerbes, Manuel, Reboredo, Margarita, Díaz-Prado, Silvia, Aparicio Gallego, Guadalupe   +6 more
openaire   +3 more sources

The Hedgehog signalling pathway regulates autophagy [PDF]

Nature Communications, 2012
Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear.
Jimenez-Sanchez, Maria, Menzies, Fiona M., Chang, Yu Yun, Simecek, Nikol, Neufeld, Thomas P., Rubinsztein, David C.   +5 more
openaire   +3 more sources

Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells. [PDF]

PLoS ONE, 2011
TRAIL is a promising therapeutic agent for human malignancies. TRAIL often requires mitochondrial dysfunction, referred to as the Type II death receptor pathway, to promote cytotoxicity.
Satoshi Kurita, Justin L Mott, Sophie C Cazanave, Christian D Fingas, Maria E Guicciardi, Steve F Bronk, Lewis R Roberts, Martin E Fernandez-Zapico, Gregory J Gores   +8 more
doaj   +1 more source

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer [PDF]

Clinical Cancer Research, 2012
AbstractThe Hedgehog (Hh) signaling pathway regulates embryonic development and may be aberrantly activated in a wide variety of human cancers. Efforts to target pathogenic Hh signaling have steadily progressed from the laboratory to the clinic, and the recent approval of the Hh pathway inhibitor vismodegib for patients with advanced basal cell ...
Ross, McMillan, William, Matsui
openaire   +2 more sources

The Hedgehog Signaling Pathway in Ischemic Tissues [PDF]

International Journal of Molecular Sciences, 2019
Hedgehog (Hh) proteins are prototypical morphogens known to regulate epithelial/mesenchymal interactions during embryonic development. In addition to its pivotal role in embryogenesis, the Hh signaling pathway may be recapitulated in post-natal life in a number of physiological and pathological conditions, including ischemia. This review highlights the
Giarretta I., Gaetani E., Bigossi M., Tondi P., Asahara T., Pola R.   +5 more
openaire   +3 more sources

Hedgehog Signaling: An Achilles’ Heel in Cancer

Translational Oncology, 2019
Hedgehog signaling pathway originally identified in the fruit fly Drosophila is an evolutionarily conserved signaling mechanism with crucial roles in embryogenesis, growth and patterning. It exerts its biological effect through a signaling mechanism that
Madiha Niyaz, Mosin S Khan, Syed Mudassar   +2 more
doaj   +1 more source

Modulators of the hedgehog signaling pathway

Bioorganic & Medicinal Chemistry, 2010
Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Philipp, Heretsch, Lito, Tzagkaroulaki, Athanassios, Giannis   +2 more
openaire   +5 more sources

Molecular Characterization of the Hedgehog Signaling Pathway and Its Necessary Function on Larval Myogenesis in the Pacific Oyster Crassostrea gigas

Frontiers in Physiology, 2018
Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li, Qi Li, Qi Li, Hong Yu, Hong Yu   +4 more
doaj   +1 more source

Expression of Sonic Hedgehog and pathway components in the embryonic mouse head: anatomical relationships between regulators of positive and negative feedback

BMC Research Notes, 2021
Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky, Xiaodong Li, Edward M. Levine   +2 more
doaj   +1 more source

Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer

Tumor Biology, 2017
The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee, Suk-young Lee, Sang Cheul Oh   +2 more
doaj   +1 more source