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The Hedgehog signalling pathway in bone formation [PDF]
International Journal of Oral Science, 2015 The Hedgehog (Hh) signalling pathway plays many important roles in development, homeostasis and tumorigenesis. The critical function of Hh signalling in bone formation has been identified in the past two decades. Here, we review the evolutionarily conserved Hh signalling mechanisms with an emphasis on the functions of the Hh signalling pathway in bone ...
Yingzi Yang +3 more
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Role of Hedgehog Signaling Pathway in NASH [PDF]
International Journal of Molecular Sciences, 2016 Non-alcoholic fatty liver disease (NAFLD) is the number one cause of chronic liver disease in the Western world. Although only a minority of patients will ultimately develop end-stage liver disease, it is not yet possible to efficiently predict who will progress and, most importantly, effective treatments are still unavailable.
Mariana Verdelho Machado, Anna Mae Diehl
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Modulators of the hedgehog signaling pathway
Bioorganic & Medicinal Chemistry, 2010 Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Lito Tzagkaroulaki +2 more
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The Hedgehog signalling pathway regulates autophagy [PDF]
Nature Communications, 2012 Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear.
Jimenez-Sanchez, Maria +5 more
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The Hedgehog Signaling Pathway in the Mouse Ovary1 [PDF]
Biology of Reproduction, 2007 The hedgehog (HH) signaling pathway plays an essential role in the Drosophila ovary, regulating cell proliferation and differentiation, but a role in the mammalian ovary has not been defined. Expression of components of the HH pathway in the mouse ovary and effects of altering HH signaling in vitro were determined.
Susan M. Quirk +4 more
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
Cell Regeneration, 2023 The overlapping roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions. Activation of Hippo signaling enhances the transcriptional output of Hedgehog signaling, and the role of ...
Chao Tang +7 more
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The Roles of Hedgehog Signaling Pathway in Radioresistance of Cervical Cancer
Dose-Response, 2019 Radiotherapy is an important treatment of cervical cancer, especially for advanced cervical cancer. According to research reports, Hedgehog signaling pathway plays an essential role in the growth, invasion, metastasis, recurrence, drug resistance, and ...
Chang Liu, Rensheng Wang
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More Surprises in the Hedgehog Signaling Pathway [PDF]
Cell, 2000 The author regrets that, owing to severe space limitations, key pieces of work have been cited using reviews rather than the original articles.
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Hedgehog signaling pathway and gastric cancer [PDF]
Cancer Biology & Therapy, 2005 Hedgehog, WNT, FGF and BMP signaling pathways network together during embryogenesis, tissue regeneration, and carcinogenesis. Aberrant activation of Hedgehog signaling pathway leads to pathological consequences in a variety of human tumors, such as gastric cancer and pancreatic cancer.
Masaru Katoh, Yuriko Katoh
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Super-enhancer hijacking drives ectopic expression of hedgehog pathway ligands in meningiomas
Nature Communications, 2023 Hedgehog signaling mediates embryologic development of the central nervous system and other tissues and is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation.
Mark W. Youngblood +36 more
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