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Modulators of the hedgehog signaling pathway
Bioorganic & Medicinal Chemistry, 2010 Since its discovery by C. Nüsslein-Volhard and E. F. Wieschaus, hedgehog (hh) signaling has come a long way. Today it is regarded as a key regulator in embryogenesis where it governs processes like cell proliferation, differentiation, and tissue patterning. Furthermore, in adults it is involved in the maintenance of stem cells, and in tissue repair and
Lito Tzagkaroulaki +2 more
openaire +6 more sources
Frontiers in Physiology, 2018 Hedgehog signaling pathway participates in a chain of necessary physiological activities and dysregulation of the hedgehog signaling has been implicated in birth defects and diseases.
Huijuan Li +4 more
doaj +1 more source
BMC Research Notes, 2021 Objective The Hedgehog pathway is a fundamental signaling pathway in organogenesis. The expression patterns of the ligand Sonic Hedgehog (Shh) and key pathway components have been studied in many tissues but direct spatial comparisons across tissues with
Crystal L. Sigulinsky +2 more
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Cell cycle and protein complex dynamics in discovering signaling pathways [PDF]
Journal of Bioinformatics and Computational Biology 2019, 2020 Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount of biological data available and the recent discoveries showing that many diseases are related to the disruption of cellular signal ...
arxiv +1 more source
Patched receptors sense, interpret and establish an epidermal Hedgehog signalling gradient [PDF]
, 2016 By using the sensitivity of single-molecule fluorescent in situ hybridization, we have precisely quantified the levels and defined the temporal and spatial distribution of Hedgehog signaling activity during embryonic skin development and discovered that ...
Adolphe, Christelle +4 more
core +2 more sources
The Hedgehog signalling pathway regulates autophagy [PDF]
Nature Communications, 2012 Autophagy is a highly conserved degradative process that removes damaged or unnecessary proteins and organelles, and recycles cytoplasmic contents during starvation. Autophagy is essential in physiological processes such as embryonic development but how autophagy is regulated by canonical developmental pathways is unclear.
Jimenez-Sanchez, Maria +5 more
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Inferring Signaling Pathways with Probabilistic Programming [PDF]
Bioinformatics 36:Supplement_2 (2020) i822-i830, 2020 Cells regulate themselves via dizzyingly complex biochemical processes called signaling pathways. These are usually depicted as a network, where nodes represent proteins and edges indicate their influence on each other. In order to understand diseases and therapies at the cellular level, it is crucial to have an accurate understanding of the signaling ...
arxiv +1 more source
Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression. [PDF]
, 2016 Gastrointestinal stromal tumors (GIST) arise within the interstitial cell of Cajal (ICC) lineage due to activating KIT/PDGFRA mutations. Both ICC and GIST possess primary cilia (PC), which coordinate PDGFRA and Hedgehog signaling, regulators of ...
Bardsley, Michael R +18 more
core +2 more sources
The Hedgehog Signaling Pathway in the Mouse Ovary1 [PDF]
Biology of Reproduction, 2007 The hedgehog (HH) signaling pathway plays an essential role in the Drosophila ovary, regulating cell proliferation and differentiation, but a role in the mammalian ovary has not been defined. Expression of components of the HH pathway in the mouse ovary and effects of altering HH signaling in vitro were determined.
Susan M. Quirk +4 more
openaire +3 more sources
Hedgehog signaling pathway as a potential target in the treatment of advanced gastric cancer
Tumor Biology, 2017 The sonic hedgehog signaling pathway is critical for cell proliferation, cell differentiation, and organ development during embryogenesis. Aberrant activation of the sonic hedgehog pathway has been associated with a variety of human cancers.
Dae-Hee Lee +2 more
doaj +1 more source