Results 41 to 50 of about 215,192 (350)

Biochemical characterization of Plasmodium falciparum parasite specific helicase 1 (PfPSH1)

FEBS Open Bio, 2019
Malaria, a disease caused by infection with parasites of the genus Plasmodium, causes millions of deaths worldwide annually. Of the five Plasmodium species that can infect humans, Plasmodium falciparum causes the most serious parasitic infection.
Manish Chauhan, Suman Sourabh, Rahena Yasmin, Isha Pahuja, Renu Tuteja   +4 more
doaj   +1 more source

Structural and Functional Studies of Chikungunya Virus nsP2

Proceedings, 2020
Chikungunya virus (CHIKV) is transmitted to humans through mosquitoes and causes Chikungunya fever. Nonstructural protein 2 (nsP2) contains an N-terminal RNA helicase with both nucleotide triphosphatase and RNA triphosphatase activities, and a C-terminal
Yee Song Law, Yaw Bia Tan, Orion Shih, Age Utt, Jie Zheng, Sainan Wang, Ming Wei Chen, Patrick R. Griffin, U-Ser Jeng, Andres Merits, Dahai Luo   +10 more
doaj   +1 more source

Superfamily 1 helicases [PDF]

Frontiers in Bioscience, 2013
Superfamily 1 helicases are nucleic acid motor proteins that couple ATP hydrolysis to translocation along, and concomitant unwinding of, DNA or RNA. This is central to many aspects of cellular DNA and RNA metabolism and, accordingly, they are implicated in a wide range of nucleic acid processing events including DNA replication, recombination and ...
Gilhooly, Neville Surain, Gwynn, Emma Jane, Dillingham, Mark Simon   +2 more
openaire   +3 more sources

Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair [PDF]

, 2009
The Mre11/Rad50/Xrs2 complex initiates IR repair by binding to the end of a double-strand break, resulting in 5′ to 3′ exonuclease degradation creating a single-stranded 3′ overhang competent for strand invasion into the unbroken chromosome. The nuclease(
AS Ivessa, B Llorente, BM Lengsfeld, CJ Frank, D D'Amours, D D'Amours, DF Fiorentino, E Alani, EJ Ivanov, EP Mimitou, G Ira, G Moncalian, J Parenteau, JB Bessler, Judith L. Campbell, K Tomita, K-H Lee, KM Trujillo, KM Trujillo, KP Hopfner, KP Hopfner, LK Lewis, LK Lewis, M Lisby, M Vernon, M Wagner, MA Resnick, Martin E. Budd, ME Budd, ME Budd, ME Budd, ME Budd, ME Budd, ME Budd, ME Budd, Michael Lichten, O Imamura, O White, P Sung, S Gangloff, S Jinks-Robertson, S Moreau, S Moreau, S Moreau, S-H Bae, S-H Bae, SH Bae, T Formosa, T Masuda-Sasa, T Weitao, T Weitao, TT Paull, TT Paull, W Choe, Z Zhu   +54 more
core   +7 more sources

BLM–DNA2–RPA–MRN and EXO1–BLM–RPA–MRN constitute two DNA end resection machineries for human DNA break repair [PDF]

, 2011
Repair of dsDNA breaks requires processing to produce 3′-terminated ssDNA. We biochemically reconstituted DNA end resection using purified human proteins: Bloom helicase (BLM); DNA2 helicase/nuclease; Exonuclease 1 (EXO1); the complex comprising MRE11 ...
Campbell, Judith L., Genschel, Jochen, Kinoshita, Eri, Kowalczykowski, Stephen C., Modrich, Paul, Nimonkar, Amitabh V., Polaczek, Piotr, Wyman, Claire   +7 more
core   +3 more sources

Arginine methylation of the DDX5 helicase RGG/RG motif by PRMT5 regulates resolution of RNA:DNA hybrids

EMBO Journal, 2019
Aberrant transcription‐associated RNA:DNA hybrid (R‐loop) formation often causes catastrophic conflicts during replication, resulting in DNA double‐strand breaks and genomic instability.
Sofiane Y Mersaoui, Zhenbao Yu, Yan Coulombe, Martin Karam, F. F. Busatto, J. Masson, S. Richard   +6 more
semanticscholar   +1 more source

Snf2 family ATPases and DExx box helicases:differences and unifying concepts from high-resolution crystal structures [PDF]

, 2006
Proteins with sequence similarity to the yeast Snf2 protein form a large family of ATPases that act to alter the structure of a diverse range of DNA–protein structures including chromatin. Snf2 family enzymes are related in sequence to DExx box helicases,
Aasland, Ahne, Akhtar, Andrew Flaus, Asturias, Auble, Auble, Auble, Bazett-Jones, Becker, Beerens, Bouazoune, Boyer, Boyer, Briggs, Caruthers, Corona, Cote, Dasgupta, Davis, Deaconescu, Dhalluin, Dumont, Durr, Eisen, Fan, Fitzgerald, Flaus, Flaus, Goldmark, Gorbalenya, Grune, Harald Dürr, Havas, Hishida, Ito, Jaskelioff, Kagalwala, Karl-Peter Hopfner, Kawaoka, Kim, Laurent, Laurent, Levin, Levin, Lia, Mahdi, Mannhaupt, Mizuguchi, Morillon, Myong, Peterson, Petukhova, Petukhova, Phelan, Pray-Grant, Quinn, Richmond, Ristic, Saha, Saha, Schild, Sengoku, Serebrov, Shen, Shinohara, Simic, Sims, Singleton, Singleton, Singleton, Smith, Soultanas, Sprouse, Stanley, Studitsky, Subramanya, Sukhodolets, Svejstrup, Swagemakers, Tai, Thoma, Tom Owen-Hughes, Tran, Tsukiyama, van den Boom, van Gool, Van Komen, Velankar, Wang, Whitehouse, Woudstra, Yu, Yu, Zhang, Zofall   +95 more
core   +4 more sources

Monomeric PcrA helicase processively unwinds plasmid lengths of DNA in the presence of the initiator protein RepD [PDF]

, 2013
The helicase PcrA unwinds DNA during asymmetric replication of plasmids, acting with an initiator protein, in our case RepD. Detailed kinetics of PcrA activity were measured using bulk solution and a single-molecule imaging technique to investigate the ...
Arbore, Arthur, Atkinson, Bird, Brune, Byrd, Byrd, Chao, Cheng, Christopher P. Toseland, Corrie, Dillingham, Dillingham, Dillingham, Dillingham, Dillingham, Fili, Fili, Gorbalenya, Greenstein, Gregory I. Mashanov, Iordanescu, Justin E. Molloy, Kunzelmann, Leatherbarrow, Lee, Levin, Liisa T. Chisty, Lohman, Lohman, Manosas, Mark S. Dillingham, Martin R. Webb, Mashanov, Natalia Fili, Niedziela-Majka, Noirot, Sellers, Singleton, Slatter, Soultanas, Soultanas, Soultanas, Subramanya, Thomas, Thomas, Toseland, Veaute, Velankar, Webb, Yamaguchi, Yang, Yarranton, Yeeles, Zhang   +54 more
core   +1 more source

Opening of DNA double strands by helicases. Active versus passive opening [PDF]

, 2002
Helicase opening of double-stranded nucleic acids may be "active" (the helicase directly destabilizes the dsNA to promote opening) or "passive" (the helicase binds ssNA available due to a thermal fluctuation which opens part of the dsNA).
A. W. Hunter, B. Alberts, C. S. Peskin, Frank Jülicher, J. Howard, J. L. Kim, M. D. Betterton, M. R. Singleton, M. R. Singleton, M. S. Dillingham, M. S. Dillingham, P. H. von Hippel, S. Korolev, S. Korolev, S. S. Velankar   +14 more
core   +2 more sources

RNA Unwinding by the Trf4/Air2/Mtr4 Polyadenylation (TRAMP) Complex [PDF]

, 2012
Many RNA-processing events in the cell nucleus involve the Trf4/Air2/Mtr4 polyadenylation (TRAMP) complex, which contains the poly(A) polymerase Trf4p, the Zn-knuckle protein Air2p, and the RNA helicase Mtr4p.
Anderson, James T., Jankowsky, Eckhard, Jia, Huijue, Wang, Xuying   +3 more
core   +2 more sources