Results 1 to 10 of about 79,274 (196)

Vutrisiran in Transthyretin Amyloidosis [PDF]

JACC: Advances
Background: Vutrisiran is an RNA interference therapeutic that has demonstrated efficacy for the treatment of patients with transthyretin amyloidosis (ATTR) with polyneuropathy and cardiomyopathy in the phase 3 HELIOS-A and HELIOS-B studies, respectively.
Ronald M. Witteles, MD, Pablo Garcia-Pavia, MD, PhD, Caroline Morbach, MD, Julian D. Gillmore, MD, PhD, Mark S. Taylor, MBBS, PhD, Isabel Conceição, MD, William B. White, MD, Cynthia Kwok, MSPH, Marianne T. Sweetser, MD, PhD, Katherine L. Boyle, MD, David Adams, MD, PhD   +10 more
doaj   +2 more sources

Phenotypic and Functional Properties of Helios+ Regulatory T Cells [PDF]

PLoS ONE, 2012
Helios, an Ikaros family transcription factor, is preferentially expressed at the mRNA and protein level in regulatory T cells. Helios expression previously appeared to be restricted to thymic-derived Treg.
Christopher J Nirschl
exaly   +2 more sources

Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells [PDF]

PLoS ONE, 2015
Helios transcription factor and semaphorin receptor Nrp-1 were originally described as constitutively expressed at high levels on CD4+Foxp3+ T regulatory cells of intrathymic origin (tTregs). On the other hand, CD4+Foxp3+ Tregs generated in the periphery
Edyta A Szurek, Anna Cebula, Maciej Pietrzak   +2 more
exaly   +2 more sources

Helios Expression Is a Marker of T Cell Activation and Proliferation [PDF]

PLoS ONE, 2011
Foxp3+ T-regulatory cells (Tregs) normally serve to attenuate immune responses and are key to maintenance of immune homeostasis. Over the past decade, Treg cells have become a major focus of research for many groups, and various functional subsets have ...
Tatiana Akimova, Ulf H Beier, Matthew H. Levine   +2 more
exaly   +2 more sources

Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios− Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals

Frontiers in Immunology, 2021
CD4 Tregs are involved in the regulation of various autoimmune diseases but believed to be highly heterogeneous. Studies have indicated that Helios controls a distinct subset of functional Tregs.
Yuyue Zhang, Jie Zhang, Yun Shi, Min Shen, Hui Lv, Shu Chen, Yingjie Feng, Heng Chen, Xinyu Xu, Tao Yang, Kuanfeng Xu   +10 more
doaj   +1 more source

Difference between CD25+Tregs and Helios+Tregs in a murine model of allergic rhinitis

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: Regulatory T or Treg cells, balance the peripheral immune response to allergens in allergic rhinitis. Traditionally, Treg (CD25+ Treg) is identified by the coexpression of Foxp3 and CD25, but this strategy does not represent the true ...
Yun-Xiu Wang, Zhao-Wei Gu, Zhi-Wei Cao
doaj   +1 more source

En el recinto común dedicado a Apolo y Helios (Platón, Lg., 945 b-948 b)

Nova Tellus, 2021
En Leyes, 945 b-948 b, Platón introduce la figura de los eúthӯnoi o “correctores” y los relaciona directamente con el culto común de Helios y Apolo. Sostengo que, al hacer esto, el filósofo ha pretendido conectar la República y las Leyes en torno a la ...
Miguel Ángel Spinassi
doaj   +1 more source

Dionysiac Associations among the Dedicants of Hosios kai Dikaios Revisiting Recently Published Inscriptions from the Mihalıççık District in North-West Galatia

Gephyra, 2020
Four new epigraphic finds from the Mihalıççık District encourage us to reconsider the role that villages and associations played among those who made dedications to the divine pair Hosios kai Dikaios.
Altay COŞKUN
doaj   +1 more source

HELIOS-expressing human CD8 T cells exhibit limited effector functions

Frontiers in Immunology, 2023
IntroductionThe transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells.
Damien Neyens, Thibault Hirsch, Achraqat Abdel Aziz Issa Abdel Hadi, Nicolas Dauguet, Christophe Vanhaver, Alexandre Bayard, Claude Wildmann, Mathieu Luyckx, Mathieu Luyckx, Jean-Luc Squifflet, Jean-Luc Squifflet, Quentin D’Hondt, Céline Duhamel, Antoine Huaux, Virginie Montiel, Mélanie Dechamps, Pierre van der Bruggen, Pierre van der Bruggen   +17 more
doaj   +1 more source

Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells

Frontiers in Immunology, 2021
BackgroundAdiponectin is an important immunomodulatory mediator in inflammatory conditions. While we previously showed that adiponectin receptor 1 (AdipoR1) is expressed in murine regulatory T cells (Tregs), its expression in human Tregs remain unknown ...
Patricia Ramos-Ramírez, Carina Malmhäll, Omar Tliba, Madeleine Rådinger, Apostolos Bossios, Apostolos Bossios   +5 more
doaj   +1 more source