Die Bibliothek als Partnerin: Klinische Daten und Forschungsdaten bei Helios
GMS Medizin – Bibliothek – Information, 2023 In medical research, there are vast amounts of health data that can be used in a variety of ways. But what about this kind of data at Helios? This article describes the existing infrastructure and the institutions who are important for the research at ...
Popoff, Liouba, Thiele, Diana
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Co-Expression of TIGIT and Helios Marks Immunosenescent CD8+ T Cells During Aging
Frontiers in Immunology, 2022 Aging leads to alterations in the immune system that result in ineffective responsiveness against pathogens. Features of this process, collectively known as immunosenescence, accumulate in CD8+ T cells with age and have been ascribed to differentiation ...
Daan K. J. Pieren +8 more
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The transcription factor Helios restrains the anti-tumor capacity of CD8+ T cells
Cell ReportsSummary: Immunotherapy has revolutionized cancer treatment, but it lacks efficacy in a sizable fraction of patients. Therefore, understanding the transcriptional networks that limit CD8+ T cell anti-tumor responses is fundamental.
Rosa M. Rubio +17 more
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Helios—Illuminating the way for lymphocyte self‐control
ImmunologyTranscription factor Helios, encoded by the IKZF2 gene, has an important role in regulatory T cells by stabilizing their suppressive phenotype. While Helios is prominently expressed in regulatory T cells, its expression extends beyond to include effector
Iivo Hetemäki +2 more
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Abatacept treatment shows a modulating effect on Treg subsets in LRBA-deficient patients [PDF]
Frontiers in ImmunologyThere has been tremendous progress in the understanding of subsets of regulatory T cells (Tregs). However, despite their theoretical importance, Treg subsets are not routinely analyzed in patients with immune dysregulation over the course of the disease ...
Sabine Donhauser +6 more
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Efficacy and Safety of Vutrisiran in Patients with Hereditary Transthyretin-mediated Amyloidosis with Polyneuropathy: Analysis of the East Asian Subpopulation from HELIOS-A [PDF]
Neurology and TherapyIntroduction In the phase 3 HELIOS-A study (NCT03759379), vutrisiran significantly improved a range of disease-related endpoints compared with an external placebo in patients with hereditary transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTRv-PN)
Jeeyoung Oh +11 more
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Virtual laser scanning with HELIOS++: A novel take on ray tracing-based simulation of topographic 3D laser scanning [PDF]
Remote Sensing of Environment, 2021 Topographic laser scanning is a remote sensing method to create detailed 3D point cloud representations of the Earth's surface. Since data acquisition is expensive, simulations can complement real data given certain premises are available: i) a model of ...
L. Winiwarter +6 more
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Helios 2 observations of solar wind turbulence decay in the inner heliosphere [PDF]
Astronomy & Astrophysics, 2023 The linear scaling of the mixed third-order moment of the magnetohydrodynamic fluctuations is used to estimate the energy transfer rate of the turbulent cascade in the expanding solar wind.
L. Sorriso-Valvo +7 more
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Helios: An Efficient Out-of-core GNN Training System on Terabyte-scale Graphs with In-memory Performance [PDF]
arXiv.org, 2023 Training graph neural networks (GNNs) on large-scale graph data holds immense promise for numerous real-world applications but remains a great challenge.
Jie Sun +8 more
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HELIOS-K 2.0 Opacity Calculator and Open-source Opacity Database for Exoplanetary Atmospheres [PDF]
Astrophysical Journal Supplement Series, 2021 Computing and using opacities is a key part of modeling and interpreting data of exoplanetary atmospheres. Since the underlying spectroscopic line lists are constantly expanding and currently include up to ∼1010–1011 transition lines, the opacity ...
S. Grimm +14 more
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