Results 1 to 10 of about 25,648 (161)

Differences in Maturation Status and Immune Phenotypes of Circulating Helios+ and Helios− Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals

Frontiers in Immunology, 2021
CD4 Tregs are involved in the regulation of various autoimmune diseases but believed to be highly heterogeneous. Studies have indicated that Helios controls a distinct subset of functional Tregs.
Yingjie Feng, Xinyu Xu, Tao Yang
exaly   +3 more sources

HELIOS-expressing human CD8 T cells exhibit limited effector functions

Frontiers in Immunology, 2023
IntroductionThe transcription factor HELIOS is primarily known for its expression in CD4 regulatory T cells, both in humans and mice. In mice, HELIOS is found in exhausted CD8 T cells.
Nicolas Dauguet, Pierre Van der Bruggen   +1 more
exaly   +3 more sources

Abatacept treatment shows a modulating effect on Treg subsets in LRBA-deficient patients [PDF]

Frontiers in Immunology
There has been tremendous progress in the understanding of subsets of regulatory T cells (Tregs). However, despite their theoretical importance, Treg subsets are not routinely analyzed in patients with immune dysregulation over the course of the disease ...
Sabine Donhauser, Emilia Salzmann-Manrique, Leon Maximilian Lueck, Julia Fekadu-Siebald, Ralf Schubert, Sabine Huenecke, Shahrzad Bakhtiar   +6 more
doaj   +2 more sources

Efficacy and Safety of Vutrisiran in Patients with Hereditary Transthyretin-mediated Amyloidosis with Polyneuropathy: Analysis of the East Asian Subpopulation from HELIOS-A [PDF]

Neurology and Therapy
Introduction In the phase 3 HELIOS-A study (NCT03759379), vutrisiran significantly improved a range of disease-related endpoints compared with an external placebo in patients with hereditary transthyretin amyloidosis (ATTRv) with polyneuropathy (ATTRv-PN)
Jeeyoung Oh, Yoshiki Sekijima, Hideki Mochizuki, Byoung Joon Kim, Ju-Hong Min, Masahisa Katsuno, Cheng Yin Tan, Yi-Chung Lee, Yohei Misumi, Weizhi Zhao, Amy Chan-Daniels, Chi-Chao Chao   +11 more
doaj   +2 more sources

Vutrisiran in Transthyretin Amyloidosis [PDF]

JACC: Advances
Background: Vutrisiran is an RNA interference therapeutic that has demonstrated efficacy for the treatment of patients with transthyretin amyloidosis (ATTR) with polyneuropathy and cardiomyopathy in the phase 3 HELIOS-A and HELIOS-B studies, respectively.
Ronald M. Witteles, MD, Pablo Garcia-Pavia, MD, PhD, Caroline Morbach, MD, Julian D. Gillmore, MD, PhD, Mark S. Taylor, MBBS, PhD, Isabel Conceição, MD, William B. White, MD, Cynthia Kwok, MSPH, Marianne T. Sweetser, MD, PhD, Katherine L. Boyle, MD, David Adams, MD, PhD   +10 more
doaj   +2 more sources

Difference between CD25+Tregs and Helios+Tregs in a murine model of allergic rhinitis

Brazilian Journal of Otorhinolaryngology, 2021
Introduction: Regulatory T or Treg cells, balance the peripheral immune response to allergens in allergic rhinitis. Traditionally, Treg (CD25+ Treg) is identified by the coexpression of Foxp3 and CD25, but this strategy does not represent the true ...
Yun-Xiu Wang, Zhao-Wei Gu, Zhi-Wei Cao
doaj   +1 more source

Phenotypic and functional properties of Helios+ regulatory T cells. [PDF]

PLoS ONE, 2012
Helios, an Ikaros family transcription factor, is preferentially expressed at the mRNA and protein level in regulatory T cells. Helios expression previously appeared to be restricted to thymic-derived Treg.
Daniel J Zabransky, Christopher J Nirschl, Nicholas M Durham, Ben V Park, Christina M Ceccato, Tullia C Bruno, Ada J Tam, Derese Getnet, Charles G Drake   +8 more
doaj   +1 more source

En el recinto común dedicado a Apolo y Helios (Platón, Lg., 945 b-948 b)

Nova Tellus, 2021
En Leyes, 945 b-948 b, Platón introduce la figura de los eúthӯnoi o “correctores” y los relaciona directamente con el culto común de Helios y Apolo. Sostengo que, al hacer esto, el filósofo ha pretendido conectar la República y las Leyes en torno a la ...
Miguel Ángel Spinassi
doaj   +1 more source

Dionysiac Associations among the Dedicants of Hosios kai Dikaios Revisiting Recently Published Inscriptions from the Mihalıççık District in North-West Galatia

Gephyra, 2020
Four new epigraphic finds from the Mihalıççık District encourage us to reconsider the role that villages and associations played among those who made dedications to the divine pair Hosios kai Dikaios.
Altay COŞKUN
doaj   +1 more source

Adiponectin/AdipoR1 Axis Promotes IL-10 Release by Human Regulatory T Cells

Frontiers in Immunology, 2021
BackgroundAdiponectin is an important immunomodulatory mediator in inflammatory conditions. While we previously showed that adiponectin receptor 1 (AdipoR1) is expressed in murine regulatory T cells (Tregs), its expression in human Tregs remain unknown ...
Patricia Ramos-Ramírez, Carina Malmhäll, Omar Tliba, Madeleine Rådinger, Apostolos Bossios, Apostolos Bossios   +5 more
doaj   +1 more source